PubMed Health⌕ Search

Biomedical subjects

J L Parrot

Publications and source records attributed to J L Parrot.

At least 19 recordsLinked to original sources
PubMed1978

Immunoglobulin E in human aqueous humor and corresponding serum. A physiopathological and clinical study.

The analysis of IgE in aqueous humor yielded an average concentration of 3.4 +/- 0.97 U/ml for 22 cataract patients and 5.5 +/- 3.42 U/ml for five uveitis patients. The IgE level in aqueous humor (IgEa.h.) of the cases examined is most probably, beside hematoocular diffusion of serum IgEs, the result of intra-ocular IgE production. In comparison with (mostly normal) IgEs levels, the IgEa.h. concentration appears relatively elevated, not only with uveitis patients, but also with cataract patients, above all when lenticular opacity is accompanied by other ophthalmic diseases (glaucoma, high myopia, diabetes). This "increase" of IgEa.h. concentration in very probably due to the radioimmunosorbent (RIST) technique employed, the most sensitive method available at the time of the present study. Thus, the calculated IgEa.h. value in the cataractous eyes should be regarded simply as approximate to the normal IgEa.h. concentration. These values are of clinical significance however, since a reference IgEa.h. mean-value is indispensable to the interpretation of pathologically high IgEa.h. levels and ethics do not permit of IgEa.h. determination in healthy eyes. The mean IgEa.h. levels of the delayed-type uveitis and cataract patients examined reveal no significant differences. IgEa.h. determination could make a contribution to the etiological clarification of, for example, immediate-type uveitis cases and intra-ocular parasitosis and serve as an appropriate model to study intra-ocular immunomechanisms.

Adult↗
PubMed1978

Original method of showing some constitutive elements of the capillary wall.

The ascorbic acid and the 1-epi-3', 4', 5', 5, 7-pentahydroxy-flavan-3-ol have been located in the blood capillary wall by an histochemical method for electron microscopy. The method consists in an intra-arterial administration of vegetal oxydases specific of the compound to put in evidence. Those oxydases fix themselves on their effectors, and the addition of osmium and lead salts gives co-precipitates opaque to electrons.

Animals↗
PubMed1977

[Endogenous histamine. Principles of prevention].

After recalling the machanisms of liberation of endogenous histamine and its fate; the author discusses the pharmacological methods of protection of the organism against histamine liberation.

Animals↗
PubMed1976

[Study of prostaglandin synthesis during anaphylactic shock in guinea pigs].

In guinea pigs actively sensitized with ovalbumin and shocked, we have measured blood histamine and histaminase, pulmonary content in cycli AMP and prostaglandins (PG) E1, E2 and F2alpha. In pulmonary efferent blood, both PGE and PGF are increased. In lung tissue, only PGF2alpha, which are bronchoconstructive mediators, are increased. Th increased level in PG seems to have two origins: first a specific increase, then an increased synthesis secondary to histamine release.

Amine Oxidase (Copper-Containing)↗
PubMed1976

[Histamine liberation and its mechanism].

The author, on the basis of his personal work, proposes a classification of the mechanisms of histamine liberation: a metabolic mechanism (acting like anaphylaxis) and a mechanism by amine displacement. Subsequently, the action on histamine of two hydrosoluble vitamins: ascorbic acid and nicotinamide is considered, in the animal as a whole and on the mastocytes of rat peritoneum.

Anaphylaxis↗
PubMed1975

[Determination of the closing volume and its value in the early detection of chronic obstructive lung disease].

The determination of the closing volume appears as a good test for the early detection of obstructive lung diseases and of disorders in the ventilation distribution. Easy to perform, its use should become extensive. To make use of this investigation under the better possible conditions, it is strictly necessary to respect methodologic norms and an excellent technology and to be aware of some morphologic anomalies in the curves.

Age Factors↗