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J L Peterse

Publications and source records attributed to J L Peterse.

119 records · Page 7Linked to original sources
PubMed1988

Recurrence of breast carcinoma after breast conserving treatment.

Clinicopathologic data were analysed of 15 patients with recurrence of carcinoma after breast conserving treatment and who underwent salvage mastectomy with curative intent. Twelve recurred in the same site as the original tumor after an average interval of 29 months; the remaining three arose elsewhere in the breast after an average, 83 months. Ten patients presented with palpable lumps, one with Paget's disease of the nipple and four with mammographical microcalcifications. Thirteen patients are alive without evidence of disease (mean follow-up 20 months), one patient died of chest wall recurrence 10 months after mastectomy and one is alive with metastatic disease 9 months after mastectomy. Extensive ductal carcinoma in situ, which was found in 53% of the initial excisions in this series, may be associated with a high risk of local recurrence.

Breast Neoplasms↗
PubMed1988

Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA.

Amplification of the neu (or c-erbB-2 or HER) oncogene is relatively frequent in human breast carcinomas. We have raised a polyclonal rabbit serum in order to detect the neu protein product in tissue sections of tumors. This serum specifically reacted with a 185 kilodaltons neu protein in SKBR-3 cells, a mammary carcinoma cell line with amplified neu. Immunohistochemistry on paraffin-embedded sections of tumors in which the neu gene was amplified showed distinct membrane staining of groups of tumor cells. Sections of tumors with normal copy numbers of neu were negative. Lymph node metastases from tumors positive for neu overexpression also showed the membrane staining pattern, whereas lymph node metastases from tumors negative for neu staining never did. Neu amplification is thus associated with neu protein overproduction in tumors and lymph node metastases, and a routine antibody staining technique can discriminate a high level of neu protein expression from levels commonly present in tumors with normal neu copy numbers.

Breast Neoplasms↗
PubMed1988

Amplification and over-expression of the neu oncogene in human breast carcinomas.

Amplification of the neu (or c-erbB-2 or HER) oncogene is found to be present in 15-30% of human breast carcinomas and has been reported to correlate with poor prognosis. We briefly review the literature on this subject with emphasis on our own results on immunohistochemical detection of neu overproduction in paraffin embedded tissue sections of human breast carcinomas.

Biomarkers, Tumor↗
PubMed1987

Ductal carcinoma in situ (DCIS) of the breast--a therapeutic dilemma.

The incidence of ductal carcinoma in situ of the breast (DCIS) is low. Multifocality and difficulties in defining the extent of the disease are the main problems in relation to the therapy. Biologic characterization still is incomplete. Ablative treatment gives a 100% cure. Prospective trials are needed to evaluate breast conserving therapy.

Breast Neoplasms↗
PubMed1984

Cytodiagnosis of non-Hodgkin's lymphoma. A morphological analysis of 215 biopsy proven cases.

A cytomorphological analysis using a large number of variables was applied to 136 fine needle aspirations and 122 imprints from 258 biopsy proven lymphoid lesions, including 203 non-Hodgkin's lymphomas (NHL), 12 true histiocytic neoplasms and 43 lymphoid hyperplasias. Characteristics of the various cell types are described using the Kiel classification predominantly. Two blindly performed consecutive cytological analyses, indicated as Cyt I and Cyt II respectively, were compared with histology. False-positive conclusions did not occur. False-negative conclusions were present in 3.7% of cases. The intra-observer reproducibility between Cyt I and Cyt II was 93%. The inter-observer reproducibility between the 4 authors was examined in 50 cases; consensus regarding malignancy, exact NHL type and benign cytology was 88%, 70% and 100% respectively. Cytodiagnosis of NHL is a reliable method with a high sensitivity which can add substantial information to tissue diagnosis in troublesome cases. Fine needle aspirations, if adequately performed, had the same cellularity, quality and cellular composition as imprints. Aspiration cytology is very useful for the selection of a representative lymph node for surgical biopsy, for the diagnosis of recurrent NHL, for staging the extent of disease, for the diagnosis of cases in which tissue biopsy is not possible, and as a variable for monitoring treatment.

Adolescent↗
PubMedDate not supplied

Fine needle aspiration cytology of radiation-induced changes in nonneoplastic breast lesions. Possible pitfalls in cytodiagnosis.

The range of radiation-induced changes in fine needle aspiration (FNA) smears of the breast is described. In 41 of more than 800 patients who underwent breast-conserving treatment, a palpable breast lesion developed, and FNA was performed. In six cases, a recurrent carcinoma was present. In the remaining cases, three patterns of nonneoplastic lesions could be discerned: epithelial atypia (14 cases), fat necrosis (10 cases) and poorly cellular smears without epithelial atypia or fat necrosis (13 cases). It is important to be familiar with the patterns of radiation-induced epithelial atypia, since such atypia may lead to a misdiagnosis of recurrent carcinoma. These atypical cells may show impressive anisocytosis and anisonucleosis; however, the nuclear/cytoplasmic ratio remains normal and an admixture of bipolar cells is present. Cell dissociation and necrotic cell debris, as often seen in breast cancer smears, were never encountered in FNA smears from radiated nonneoplastic breasts.

Adult↗