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Biomedical subjects

J L Quiles Durá

Publications and source records attributed to J L Quiles Durá.

6 recordsLinked to original sources
PubMed1997

[Neisseria meningitidis strains with decreased susceptibility to penicillin and ampicillin].

Thirty-eight patients (31 children and 7 adults) with meningococcal infection (sepsis and/or meningitis) were studied. The strain most frequently isolated was B (44.7%), followed by C (31.6%). Of the strains isolated, 52.6% were moderately resistant to penicillin (91.6% if only strain C was considered). No resistance to cephotaxime or chloramphenicol was found. Even though patients with moderately resistant strains treated with penicillin G evolved satisfactorily (minimum inhibitory concentrations 0.12-0.50 microgram/ml), the possible appearance of more resistant strains and/or of strains that produce beta-lactamase leads us to the conclusion that cephotaxime is the treatment of choice until an antibiogram is available.

Adolescent↗
PubMed1997

[Tuberculosis outbreak at a public school].

BACKGROUND: At school there are special circumstances of living together and a particular susceptibility, which favour the emergence of tuberculosis microepidemics. We report here the microepidemic occurred at a school among 9-year old children. METHODS: After ruling out a possible familiar source in a child with pulmonary tuberculosis, we detected a case with high bacillar shedding in a female teacher and conducted a tuberculin search among children and teachers, initially outlining the theoretical groups at risk. Tuberculin positive children underwent chest-X-ray and when abnormalities were found, children were derived to the pediatrician for chemotherapy. All converters received secondary chemoprophylaxis and all non-respondents primary chemoprophylaxis. RESULTS: The classroom where the teacher spent most of het time had a higher rate of converters (70%) than other classroom, where the index teacher spent only a partial time (40%; RR: 1.75; CI: 1.06-2.88) or the collective of teachers (45.4%; RR: 1.45; CI: 0.94-2.23). Three additional cases of secondary disease were detected, all of them children. The initial compliance with chemoprophylaxis was greater among (for) children (97.0%) than among teachers (41.6%). Among children there was one case of tuberculin conversion compared with three cases among teachers. No additional cases were detected; also, an abnormal rate of reactors outside the initially studied groups was also not detected. CONCLUSIONS: Our results somehow agree with those reported from other school outbreaks. To note the anergy and lack of symptoms in the index case and the suggestion to delineate the degree of spending hours together to identify groups with a higher theoretical risk of being infected. Thus, an unnecessary expense of resources and a social alarm would be avoided.

Adult↗
PubMed1993

[The determination of IgG subclasses in healthy children by ELISA with monoclonal antibodies].

The age at which the different IgG subclasses reach stable values has not been uniformly established to date. In this study the concentration of IgG1, IgG2, IgG3 and IgG4 has been determined in the serum of 164 children (from 1 to 14 years of age) and 20 healthy adults, by using a monoclonal antibody enzyme immunoassay. The geometric mean, standard deviation and coefficient of correlation were obtained. Results showed a gradual increase in the levels of the different subclasses throughout age. The time at which the adult concentrations were obtained varied and these adult levels were not necessarily the highest values. During the first year of life, the level of IgG1 is already high and by 6-7 years its serum concentration represented 90% of the adult IgG concentration. IgG2, IgG3 and IgG4 were initially detected at low levels. IgG2 increased rapidly until it reached a stable value at 9-10 years of age. Adult values were obtained at 10-11 years of age for IgG3 and 7-8 years of age for IgG4.

Adolescent↗
PubMed1989

[Alkaline phosphatase in the intestinal mucosa of children with the malabsorption syndrome].

110 children suffering from malabsorption underwent several biopsies of the gut to confirm coeliac disease (CD) following the ESPGAN criteria. We studied the values for alkaline phosphatase (AP) in the intestinal mucosa after gluten challenge. In 42 patients the after challenge biopsy was normal, thus excluding coeliac disease. In 68 children the mucosa was severely damaged confirming CD. In all biopsy specimens lactase, invertase, maltase and alkaline phosphatase were measured. We found a good correlation between PA values and severity of mucosal damage, showing that measurement of PA in the mucosa is helpful in assessing the degree of mucosal atrophy in children suffering from malabsorption.

Alkaline Phosphatase↗