Biomedical subjects

J L Razdan

Publications and source records attributed to J L Razdan.

11 recordsLinked to original sources

PubMed1991

Carcinoma penis.

In the present study 90 cases of carcinoma penis were studied. The disease is more common after the age of 40 years; phimosis was found to be most important predisposing factor. Most common presentation was proliferative lesion with commonest involvement of glans penis. All the cases were of squamous cell carcinoma except one case of malignant melanoma. Clinical determination of lymph node metastasis is falacious as there was discrepancy between clinical and histopathological stage of the disease in 26.67% of cases. Therefore lymph node biopsy at the time of primary surgery is advocated. The result of total amputation is better than other mode of treatment.

Adult↗

PubMed1987

Circadian periodicity of plasma 17-hydroxycorticosteroids in advanced breast cancer.

Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in ten patients with advanced breast cancer and ten healthy volunteers. A marked rhythm in plasma 17-OHCS concentration was noticed in normal controls; the maximum concentration occurred at 0800 hr followed by a consistent decline throughout the daytime, reaching a minimum at 0000 hr. The circadian rhythm of plasma 17-OHCS was found to be deranged in six of the patients with breast cancer, but a normal rhythmic pattern was seen in the remaining four patients, although the values remained elevated at all time points of the 24-hr cycle in the patients with breast cancer compared to the healthy volunteers. The normal and altered plasma 17-OHCS rhythms in the patients presumably could be due to individual susceptibility and response to the pathophysiological stress of cancer.

17-Hydroxycorticosteroids↗

PubMed1977