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Biomedical subjects

J L Rose

Publications and source records attributed to J L Rose.

14 recordsLinked to original sources
PubMed2001

Implementing guided wave mode control by use of a phased transducer array.

A multi-channel time-delay system has been built and applied to a transducer array for implementing guided wave mode control. The time-delay system has a capability of sending high energy controllable tone-burst signals from eight independent channels with arbitrary time delays from 0 to 30 microseconds with resolution of 0.025 microsecond. Software time delays are also provided for summing up received signals of each channel. Theoretical discussions indicate the impact of the time delay capability on the bandwidth and sensitivity improvement of a transducer array for guided wave generation. Determination of both physical and software time delay values is based on a knowledge of dispersion curves and element spacing. Based on reference signals, a non-knowledge-based automatic time-delay searching algorithm was introduced for guided wave mode selection. Experiments were conducted with a phased comb transducer array mounted on a carbon steel pipe. The experimental results show that signal to noise ratio has been greatly improved by use of the time-delay system. Some other benefits of the phased array, including unidirection generation and mode control flexibility, are discussed.

Journal Article↗
PubMed1999

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.

We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to Steel factor, and Socs1 inducibly binds to the Kit receptor tyrosine kinase via its Src homology 2 (SH2) domain. Previous studies have shown that Socs1 suppresses cytokine-mediated differentiation in M1 cells inhibiting Janus family kinases. In contrast, constitutive expression of Socs1 suppresses the mitogenic potential of Kit while maintaining Steel factor-dependent cell survival signals. Unlike Janus kinases, Socs1 does not inhibit the catalytic activity of the Kit tyrosine kinase. In order to define the mechanism by which Socs1-mediated suppression of Kit-dependent mitogenesis occurs, we demonstrate that Socs1 binds to the signalling proteins Grb-2 and the Rho-family guanine nucleotide exchange factors Vav. We show that Grb2 binds Socs1 via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1, and Socs1 binds to the N-terminal regulatory region of Vav. These data suggest that Socs1 is an inducible switch which modulates proliferative signals in favour of cell survival signals and functions as an adaptor protein in receptor tyrosine kinase signalling pathways.

Adaptor Proteins, Signal Transducing↗
PubMed1999

Mirizzi syndrome: A rare cause of obstructive jaundice.

Mirizzi syndrome is a rare cause of bile duct obstruction secondary to extrinsic compression of the hepatic duct by stones impacted in the cystic duct or infundibulum of the gallbladder. The suspicion of Mirizzi syndrome primarily relies on radiographic means such as ultrasound, computed tomography and cholangiography. The recognition of this rare syndrome is crucial in developing the proper treatment approach. We present 3 cases of Mirizzi syndrome and a review of the literature pertaining to the diagnosis and treatment of this rare cause of obstructive jaundice.

Adult↗
PubMed1997

Perception-action coupling in the development of visual control of posture.

In this investigation of developmental changes in the coordination of perceived optical flow and postural responses, 4 age groups of infants (5-, 7-, 9-, and 13-month-olds) were tested while seated on a force plate in a "moving room." During each trial the walls oscillated in an anteroposterior direction for 12 s, and the postural sway of the infant was measured. The results revealed that infants perceived the frequency and amplitude of the optical flow and scaled their postural responses to the visual information. This scaling was present even before infants could sit without support, but it showed considerable improvement during the period when infants learn to sit. Taken together, these results suggest that the visuomotor coordination necessary for controlling sitting is functional prior to the onset of independent sitting but becomes more finely tuned with experience.

Age Factors↗
PubMed1994

Maternal influences on milk intake in SHR and WKY pups.

Mother to pup milk transfer was examined in the spontaneously hypertensive rat (SHR) and its normotensive progenitor, the Wistar-Kyoto (WKY). Litters of SHR and WKY pups were either reared by their natural mothers or cross-fostered to mothers of the opposite strain shortly after birth. At postpartum days 7 and 14, pup body weights were monitored throughout a 2-h maternal separation period followed by a 3-h refeeding period during which pups remained with their mothers. Weight increases of pups over the refeeding period served as an indirect measure of milk ingestion. At postpartum day 7, both SHR and WKY pups nursed by SHR mothers received lower quantities of milk compared to their counterparts nursed by WKY mothers. Maternal strain differences in milk transfer were largely attenuated at postpartum day 14. The different nutritional environments provided by SHR and WKY mothers may mediate the alterations in offspring cardiovascular physiology and physical development that occur with reciprocal cross-fostering.

Animals↗
PubMed1994

A computer model for simulating ultrasonic scattering in biological tissues with high scatterer concentration.

Scattering of ultrasonic waves by biological tissues at different scatterer concentrations is investigated using one- and two-dimensional computer simulation models. The backscattered power as a function of scatterer concentrations is calculated using two types of incident waves, a Gaussian shaped pulse and a continuous wave (CW). The simulation results are in good agreement with the Percus-Yevick packing theory within the scatterer concentrations, from 0% to 100% in one-dimensional (1D) space, and 0% to 46% in two-dimensional (2D) space. In all cases, the simulation results from a pulsed incident wave show a much smaller standard deviation (SD) than those from an incident CW. The simulation can serve as a useful tool to verify scattering theories, simulate different experimental conditions, and to investigate the interaction between the scatterer properties and the scattering of ultrasonic waves. More importantly, the 2D simulation procedure serves as an initial step toward the final realization of a true three-dimensional (3D) simulation of ultrasonic scattering in biological tissues.

Blood↗
PubMed1983

Ultrasonic tissue characterization of fetal lung, liver, and placenta for the purpose of assessing fetal maturity.

The purpose of this research effort was to establish a physical basis for the development of an accurate noninvasive technique to differentiate between mature and immature fetal tissues, particularly the lung and placenta. The research utilized RF waveform analysis via a microcomputer-based digital processing system interfaced directly to a standard real-time clinical diagnostic ultrasound instrument. Differences between the frequency spectra of the RF waveforms for mature and immature fetal tissues could be demonstrated in accordance with proposed tissue models.

Abdomen↗
PubMedDate not supplied

Characterization of benign and malignant tissues of the thyroid gland. An ultrasonic approach using RF waveform analysis and pattern recognition.

A physical basis was developed for an accurate noninvasive technique to differentiate malignant thyroid tumors from benign lesions based upon a frequency-dependent attenuation model. The research effort utilized RF waveform analysis via a minicomputer based digital processing system. Data collection was performed using a standard clinical B-Mode diagnostic instrument with a transducer specially designed for imaging the thyroid gland. Differences between the frequency spectra of the RF waveforms for benign and malignant pathologies could be demonstrated in accordance with the proposed model.

Diagnosis, Differential↗