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Biomedical subjects

J L Saraux

Publications and source records attributed to J L Saraux.

13 recordsLinked to original sources
PubMed1997

Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome.

Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.

Adult↗
PubMed1993

Arterial and mixed venous acid-base status in patients with cirrhosis. Influence of liver failure.

Although it has been established that liver failure is associated with arterial hypocapnia and alkalaemia (i.e., respiratory alkalosis), the influence of liver failure on mixed venous acid-base status has not yet been studied. Thus, arterial and mixed venous acid-base status were simultaneously measured in controls and in a large series of patients with cirrhosis. Grade B patients (n = 28) or Grade C patients (n = 21) had significantly lower arterial and mixed venous carbon dioxide tensions than controls (n = 29). Grade B or Grade C patients also had significantly higher arterial, mixed venous pH, and lower mixed venous bicarbonate concentrations than controls. Among Grade A patients (n = 27), those with the lowest Pugh's score (i.e., equal to five) had significantly lower mixed venous carbon dioxide tension than controls. The other arterial and mixed venous acid-base values did not differ significantly between Grade A patients with the lowest Pugh's score and controls. Grade A patients with a Pugh's score equal to six and Grade B patients had similar acid-base disorders. No significant differences were found between groups concerning the anion gap and plasma chloride concentrations. In conclusion, this study shows that in Grade B or C patients, respiratory alkalosis was responsible for mixed venous hypocapnia, alkalaemia and hypobicarbonataemia. In addition, in Grade A patients with the lowest Pugh's score (equal to five), analysis of arterial and mixed venous blood revealed that mixed venous hypocapnia was the sole anomaly of the acid-base status. This last finding suggests that mixed venous hypocapnia might be an early event preceding the onset of arterial hypocapnia.

Alkalosis, Respiratory↗
PubMed1988

Hepatitis tuberculosis presenting as tumoral disease on ultrasonography.

Macronodular involvement of the liver is a rare manifestation of hepatitis tuberculosis. Two cases of this pseudotumoral form are reported on ultrasonography, demonstrating multiple hypoechoic nodules distributed throughout the liver. The authors state the difficulty in differentiating this form in its atypical presentation from lymphomatous or secondary malignancies. They stress the importance of the bacteriological and/or histological diagnosis which can be performed with fine-needle percutaneous biopsy under ultrasound guidance and which allows effective therapy.

Adult↗
PubMed1987

Pulmonary oedema during pulmonary embolism.

Pulmonary oedema during angiographically proved massive pulmonary embolism without left ventricular failure is unusual. A few previous reports have used haemodynamic data obtained during the acute phase to rule out left ventricular failure. The following case, which we were able to observe for a period of 4 years has given further evidence of uninvolved left ventricular function.

Female↗
PubMed1985

[Viral hepatitis B in health personnel].

Currently published studies indicate that the prevalence of serological evidence of hepatitis B viral infection is two to five times higher among health workers than in the general population. Repeated contact with blood specimens is essential for the transmission of hepatitis B to health workers. In particular, accidental wounds produced by used needles, especially needles contaminated with blood from Ag H be positive individuals, are frequently followed by clinical or serological evidence of viral hepatitis. The prevalence of serological evidence of hepatitis B infection increases in proportion to the duration of occupational exposure, the age of the health worker and the size of the city in which he is employed. In contrast, frequent patient contacts not involving exposure to blood products are not a major risk factor. Although unusual, the transmission of hepatitis B virus from chronically infected health workers to their patients has been described.

Age Factors↗