Biomedical subjects

J L Scaro

Publications and source records attributed to J L Scaro.

At least 37 records · Page 2Linked to original sources

PubMed1977

[Erythropoiesis in the mouse following chronic administration of small doses of busulphan (author's transl)].

After both splenectomized and non-splenectomized mice had received a total amount of five doses of Busulfan at a rate of 0.14 mg/48 h, the recovery of their erythropoietic organs through the addition of 59Fe was investigated, after the cytostatic treatment had been cut off. In the non-splenectomized animals recovery was clear, keeping high 59Fe uptake values, significantly above normal, throughout the 21 days of the experiment. In the splenectomized mice, 59Fe uptake reached a peak of 38 per cent three days after the supply had been cut off, and from then on it descended to subnormal values.

Animals↗

PubMed1976

[Effect of a beta-adrenergic blocking agent on erythropoietin production in the mouse (author's transl)].

The effects of the beta-adrenergic blocking agent (propranolol) on erythropoietin production in carbon monoxide intoxicated mice were studied. The raise in plasma erythropoietin after a 4 hour intoxication with carbon monoxide was 47% less in the propranolol treated group. A decrease of 65% in the endogenous erythropoietic response after 75 minutes of carbon monoxide intoxication was found in policithemic treated mice, as against the untreated ones. The tissue oxygen tension was reduced in the propranolol treated group. No changes was found in the hemoglobin oxygen affinity.

Animals↗

PubMed1975

Carbon monoxide and erythropoietin production in mice.

The effects of hypoxemia caused by hypoxia (H-H) and CO (H-CO) on the production of erythropoietin (ESF) in mice were investigated. When mice breathed for 6 hr mixtures of air containing 0.1% of CO or a mixture of air and nitrogen with a pO2 of 52 mm Hg, the tissue pO2 as measured by the gas pocket technique was 16.9 +/- 1.1 and 17.1 +/- 1.4 (mean +/- S.D.), respectively. Plasma ESF content in H-CO mice, however, was twice higher than in the H-H mice. The greater ESF production in H-CO was associated to a significantly less hyperventilatory response as measured by acid-base balance changes and to a lower O2 consumption and was interpreted as the result of displacement of the OHb curve in opposite directions. The ESF organ appears thus to be sensitive to variations in the amount of O2 delivered to the tissues but independent of the arterial pO2.

Acid-Base Equilibrium↗

PubMed1974