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J L Senon

Publications and source records attributed to J L Senon.

7 recordsLinked to original sources
PubMedDate not supplied

[Anticonvulsants in agitation and behavior disorders in demented subjects. Report of 8 cases].

Aggressive agitation, agitation and insomnia with generalized anxiety are commonly observed in Alzheimer's disease. These symptoms remain a principal problem in the clinical management of elderly patients. Neuroleptics are commonly the selected medication for controlling severe aggression, especially the violent out bursts often seen in demented patients. Their use is frequently complicated by side effects, particularly somnolence and confusion. Valpromide and Carbamazepine have been efficacy alternatives and very well tolerated. We report eight cases of demented patients who presented an agitation and aggressive behaviors and had been treated with Valpromide or Carbamazepine. The patients agitation was well controlled at that point and had no apparent side effects. A combination Valpromide or Carbamazepine with neuroleptics permitted a reduction doses of neuroleptics and their side effects. We think that these behaviors disorders belong to the mood disorders. The symptomatology is modified because an alteration of cognitive faculty.

Aged↗
PubMedDate not supplied

[Pharmacokinetics of neuroleptics].

Clinical pharmacokinetics of antipsychotics has been handicapped by the necessity of accurately measuring nanomolar or even subnanomolar concentrations of the drug and its active metabolites in plasma. The knowledge of fundamental pharmacokinetic properties of antipsychotic drugs has been possible with the discovery of analytical methods measuring plasma concentrations such as Radio-Receptor Assay (R.R.A.), or specific assay methods: Gas Liquid Chromatography (G.L.C.), High Performance Liquid Chromatography (H.P.L.C.) or Radioimmuno-assay. Pharmacokinetic factors of commonly used antipsychotic drugs and Depot Antipsychotics are presented. The clinical utility of plasma monitoring of antipsychotic drugs is discussed: can monitoring help to obtain an optimal therapeutic response and reduce the incidence of side effects and tardive dyskinesia?

Adult↗