Biomedical subjects

J L Wisnicki

Publications and source records attributed to J L Wisnicki.

6 recordsLinked to original sources

PubMed1987

Percutaneous desmotomy of digits for stiffness from fixed edema.

A simple technique, not previously described, has been successful in achieving increased motion of contracted metacarpophalangeal and proximal interphalangeal joints of the hand. The procedure involves percutaneous sectioning of collateral ligaments followed by joint manipulation. Experience with 65 stiff joints treated by this minimally invasive technique followed by physical therapy revealed an average final gain of 28 degrees for metacarpophalangeal joints and 19 degrees for proximal interphalangeal joints. Mean follow-up was 13 months. This compares favorably to the more aggressive technique of open arthrolysis, thus offering a simple and effective treatment alternative.

Adult↗

PubMed1986

Current concepts in burn care.

The understanding of and care for burn trauma have become increasingly sophisticated. A review of important clinical and laboratory conditions over the past five years highlights current thought and future trends in burn management.

Burns↗

PubMed1984

Hemangiomas and vascular malformations.

The classification, natural history, and treatment of hemangiomas, arteriovenous fistulas, lymphangiomas, and port-wine stains are in many respects as puzzling now as they were fifty years ago. A review of the literature assesses the progress made and addresses the questions yet to be answered.

Arteriovenous Fistula↗

PubMed1980

A direct analysis of methotrexate, dichloromethotrexate and their 7-hydroxy metabolites in plasma by high pressure liquid chromatography.

Plasma levels of methotrexate, dichloromethotrexate, and their 7-hydroxy metabolites can be determined quickly and accurately by direct analysis in a high pressure liquid chromatographic system. This system utilizes a precolumn of CO:Pell ODS resin to protect the analytical mu-Bondapak C18 column. The precolumn also provides a bed for extraction of drugs from the plasma proteins which are trapped in it. Elution with a paired ion solvent provides good recovery of methotrexate from the plasma and excellent separation on the column. The primary advantages of this system are its speed and simplicity combined with its ability to determine the plasma level of parent drug and its metabolite simultaneously.

Animals↗

PubMed1979

Analysis of lidocaine and its dealkylated metabolites by high-pressure liquid chromatography.

A high-pressure liquid chromatographic method is presented for determining lidocaine and its dealkylated metabolites, monoethylglycinexylidide and glycinexylidide, in plasma. This method uses 20-microliter samples injected directly through a pre-column onto a C18 analytical column. It is fast, sensitive and linear over a concentration range of 1--10 microgram/ml. Since the method requires no preliminary treatment of the plasma, it provides a practical means of monitoring lidocaine and its metabolites in therapeutic situations.

Alkylation↗

PubMed1978

Analysis of methotrexate and 7-hydroxymethotrexate by high-pressure liquid chromatography.

The use of high-dose methotrexate (MTX) therapy in cancer chemotherapy has intensified the need to monitor the purity of this drug. A high-pressure liquid chromatographic method, which utilizes ion-pairing on a mu-Bondapak C18 column, has been developed for this purpose. This method provides an efficient and highly sensitive method for detecting impurities in commercially available MTX. As has been demonstrated previously, patients receiving high-dose MTX therapy metabolize some of this drug to 7-hydroxymethotrexate (7-hydroxy-MTX), a derivative which is considerably less soluble than MTX itself. Consequently, 7-hydroxy-MTX may contribute to the renal toxicity commonly associated with high-dose therapy. An assay similar to the one described above is also applicable to this problem and can be used to assay MTX and 7-hydroxy-MTX directly in patients' urine.

Child↗