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Biomedical subjects

J L Zaidman

Publications and source records attributed to J L Zaidman.

36 records · Page 2Linked to original sources
PubMed1985

Effect of sodium valproate on subcellular fraction enzymes in rat liver.

Previous observations that valproic acid (VPA) causes hepatic damage prompted us to investigate the effect of large doses of the drug (0.6, 1.2 and 1.8 mmol/kg/day) on a number of liver enzymes located on different subcellular fractions. In mitochondria, glutamate dehydrogenase, aspartate aminotransferase and ornithine carbamoyltransferase were significantly increased (1.8 mmol/kg/day). In microsomes, gamma-glutamyltransferase activity increased significantly (1.8 mmol/kg) and cytochrome P-450 content decreased significantly (1.2 and 1.8 mmol/kg). In cytosol, both aspartate and alanine aminotransferase activities were increased at all dose levels. These results indicate that VPA induces dose-dependent changes in some liver enzyme activities.

Animals↗
PubMed1981

Metabolic effects of intramuscular and oral administration of ritodrine in pregnancy.

The metabolic effects of ritodrine, 80 mg/day, administered intramuscularly in the third trimester of pregnancy to 14 patients for 5 days and per os to 10 patients for 10 days were investigated. Each patient was considered at high risk for premature labor. Intravenous glucose tolerance and insulin, triglyceride, and electrolyte levels were assessed before and at the end of treatment with ritodrine. Intramuscularly or orally administered ritodrine in 10-mg doses 8 times a day did not influence carbohydrate homeostasis. Triglyceride levels fell significantly after intramuscular administration, whereas serum potassium levels increased during treatment. This study suggests that ritodrine administered intramuscularly or orally is metabolically safe in nondiabetic pregnant women.

Administration, Oral↗
PubMed1979

Metabolic effects of intravenous ritodrine infusion during pregnancy.

The effect of intravenous administration of ritodrine on blood glucose, insulin, free fatty acids and electrolytes in 17 third-trimester gravidas was investigated. A highly significant increase in blood glucose, insulin and free fatty acids and a marked decrease in serum potassium levels were registered. No significant changes during ritodrine infusion were recorded in serum levels of sodium, chloride, calcium, phosphorus and magnesium. No cardiac arrhythmias or electrocardiographic deteriorations occurred. While intravenous ritodrine administration seems to be safe in normal pregnancy, there may be a risk in diabetic patients, digitalized cases and those patients being treated with diuretics.

Adult↗
PubMed1978

Abetalipoproteinemia treated with parenteral and oral vitamins A and E, and with medium chain triglycerides.

An 11-year-old girl with abetalipoproteinemia was treated with parenteral vitamin A and vitamin E for two and a half years. Some improvement in neurological and visual deficits was noted. On changing to oral vitamin E and later with addition of medium chain triglycerides (MCT) to the diet, a considerable improvement in her general wellbeing, neuromuscular lesions and ophthalmological symptoms was noted. This regimen is being adhered to for five and a half years. The condition is stable with no further improvement.

Abetalipoproteinemia↗
PubMed1978

Combined glucose phosphate isomerase and glucose-6-phosphate dehydrogenase deficiency of erythrocytes.

A patient with combined deficiency of erythrocyte glucose phosphate isomerase (GPI) and glucose-6-phosphate dehydrogenase (G6PD) is presented. The propositus has persistent unconjugated hyperbilirubinemia. One of his two brothers exhibits the same rare enzymatic defect, but without any clinical symptoms. The electrophoretic pattern of GPI showed GPI type 1. There seems to be a correlation between the unconjugated hyperbilirubinemia and the combined enzymopathy in our patient.

Adult↗
PubMed1976

Studies on urolithiasis in Israel.

The composition of 1,000 kidney stones in our area of Israel was analyzed. The predominant stones were a combination of calcium oxalate and calcium phosphate, and uric acid. We used chemical analysis to determine the relative incidence of urinary calculi in 500 patients of various ages and ethnic groups. The incidence of calcium oxalate and calcium phosphate calculi (44 per cent) in Jews born in Israel was lower than in other ethnic groups (54 to 64 per cent). The incidence of uric acid stones in Jews born in Israel, Lebanon, Iran, Iraq and Syria, and the Ashkenazim (16 to 29 per cent) was 2 to 3 times higher than in other groups. In more than 60 per cent of the patients urolithiasis developed after they were 20 years old. The age at onset was significantly younger in Jews born in Israel (25.7 per cent) and North Africa (13.8 per cent), and in Arabs (18 per cent).

Adult↗