[Moratorium on the Kveim test].
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Creutzfeldt-Jakob Syndrome↗
Biomedical subjects
J López Haldón
Publications and source records attributed to J López Haldón.
[Hypothyroidism and myocardial damage in cardiac donors].
BACKGROUND AND OBJECTIVES: Brain death may induce myocardial contractile dysfunction and hypothyroidism. This myocardial dysfunction is a limiting factor when considering donor heart for transplantation. Myocardial damage has shown to be the mechanism in which contractile dysfunction is established in donors. On the other hand, hypothyroidism has been evoked as a major cause of cardiovascular disorders in brain dead subjects. It is not known whether any relationship exists between hypothyroidism and myocardial damage that appear in brain death. In this study myocardial damage and thyroid status are quantified in a donor population, and whether a correlation between hypothyroidism and myocardial damage exists is analyzed. PATIENTS AND METHOD: Serum samples from 45 cardiac donors were examined for cardiac troponins T and I as myocardial damage markers, as well as thyroid hormones. Correlations between cardiac troponins and thyroid hormones were assessed. RESULTS: One or both cardiac troponins were elevated in 19 donors (42.2%). Hypothyroidism was a very frequent finding, since it was present in 39 donors (86.7%). No correlation was observed between any of the myocardial damage markers and thriiodothyronine levels. CONCLUSIONS: Hypothyroidism and myocardial damage are common in brain dead donors. No association exists between both disorders.
Adolescent↗
[Exercise physiology and the rehabilitation of the heart transplant patient].
Cardiac transplantation has succeeded in improving the survival of the patients with terminal heart failure spectacularly. Nevertheless, in the transplant recipients the cardiac response to the effort is limited. In order to increase the cardiac output, the denervated heart needs an important increase of the precharge, since its chronotropic response is reduced. This rise of the precharge, in a restrictive heart in itself, leads to a disproportionate increase of the filling pressures. This limits the functional capacity of the patient due to the feeling of dyspnea. A program of cardiac rehabilitation, that includes a physical continued training, gets to improve the physiopathologic response to the exercise of the transplant heart.
Exercise↗