Biomedical subjects

J López-Herce Cid

Publications and source records attributed to J López-Herce Cid.

At least 19 recordsLinked to original sources

PubMed2006

[Use of the Bispectral Index in monitoring critically-ill children].

The Bispectral Index (BIS) is a single numeric value that indicates the depth of hypnosis by estimating the level of electrical activity in the brain through analysis of the frequency bands in the electroencephalogram. The BIS was primarily developed to monitor the level of hypnosis during surgery and has recently begun to be used in critically-ill patients. Currently, there is little experience of the BIS in critically-ill children. We present 6 cases that illustrate the utility of BIS monitoring in the PICU. We assessed sedation and analgesia during mechanical ventilation with and without neuromuscular block in two patients, and the effect of anesthetic agents during a surgical procedure in the PICU. The BIS was also useful in the continuous monitoring of the level of consciousness in a patient with encephalitis and in the early detection of brain death. Pacer-induced artefacts in the BIS value are also described. We conclude that BIS monitoring may be a useful, noninvasive method for assessing the level of hypnosis in critically-ill children.

Brain Death↗

PubMed2006

[Definitions and prevention of cardiorespiratory arrest in children].

In cardiopulmonary resuscitation ages are divided in neonates (in the inmediate period after the birth), infant (from birth to 12 months) and child (from 12 months to puberty). Respiratory arrest is defined by the absence of spontaneous respiration (apnea) or a severe respiratory insufficiency (agonal gasping) that require respiratory assistance. Cardiac arrest is defined as the absence of central arterial pulse or signs of circulation (movement, cough or normal breathing) or the presence of a central pulse less than 60 lpm in a child who does not respond, not breath and with poor perfusion. After resuscitation the return of spontaneous circulation is defined as the recuperation of central arterial pulse or signs of circulation in a child with previous cardiorespiratory arrest. It is maintained when the duration is longer than 20 minutes. Injuries, sudden infant death syndrome, and respiratory diseases are the most frequent etiologies of cardiorrespiratory arrest in children. The prevention and the formation of citizens in basic cardiopulmonary resuscitation are the most effective measures to reduce the mortality of cardiorespiratory arrest in children.

Cardiopulmonary Resuscitation↗

PubMed2006

[Basic life support in pediatrics].

Basic life support (BLS) is the combination of maneuvers that identifies the child in cardiopulmonary arrest and initiates the substitution of respiratory and circulatory function, without the use of technical adjuncts, until the child can receive more advanced treatment. BLS includes a sequence of steps or maneuvers that should be performed sequentially: ensuring the safety of rescuer and child, assessing unconsciousness, calling for help, positioning the victim, opening the airway, assessing breathing, ventilating, assessing signs of circulation and/or central arterial pulse, performing chest compressions, activating the emergency medical service system, and checking the results of resuscitation. The most important changes in the new guidelines are the compression: ventilation ratio and the algorithm for relieving foreign body airway obstruction. A compression/ ventilation ratio of 30:2 will be recommended for lay rescuers of infants, children and adults. Health professionals will use a compression: ventilation ratio of 15:2 for infants and children. If the health professional is alone, he/she may also use a ratio of 30:2 to avoid fatigue. In the algorithm for relieving foreign body airway obstruction, when the child becomes unconscious, the maneuvers will be similar to the BLS sequence with chest compressions (functioning as a deobstruction procedure) and ventilation, with reassessment of the mouth every 2 min to check for a foreign body, and evaluation of breathing and the presence of vital signs. BLS maneuvers are easy to learn and can be performed by anyone with adequate training. Therefore, BLS should be taught to all citizens.

Algorithms↗

PubMed2006

[Pediatric advanced life support].

Advanced life support (ALS) includes all the procedures and maneuvers used to restore spontaneous circulation and breathing, thus minimizing brain injury. The fundamental steps of ALS are airway control with adjuncts, ventilation with 100% oxygen, vascular access and fluid and drug administration, and monitoring to diagnose and treat arrhythmias. Airway control can be achieved by means of oropharyngeal airway, endotracheal intubation, and alternative methods (laryngeal mask and cricothyroidotomy). Vascular access can be achieved by the peripheral venous, intraosseous, central venous, and tracheal routes. The most frequent rhythms found in children with cardiorespiratory arrest are nonshockable (asystole, severe bradycardia, pulseless electrical activity, and complete atrioventricular block). In these cases, adrenaline continues to be the essential drug. Currently, low adrenaline doses (0.01 mg/kg IV and 0.1 mg/kg intratracheal administration) are recommended throughout the resuscitation period. Amiodarone (5 mg/kg) is the drug of choice in cases of ventricular fibrillation refractory to electric shock. The treatment sequence for shockable rhythms (ventricular fibrillation and pulseless ventricular tachycardia) is one 4 J/kg electric shock, followed by cardiopulmonary resuscitation (chest compressions and ventilation) for 2 minutes with subsequent reassessment of the electrocardiographic rhythm. Adrenaline must be administered immediately before the third electric shock and subsequently every 3-5 minutes. Amiodarone must be administered immediately before the fourth shock.

Advanced Cardiac Life Support↗

PubMed2006

[Cardiorespiratory arrest in children with trauma].

OBJECTIVE: To analyze the characteristics and outcome of cardiorespiratory arrest secondary to trauma in children. PATIENTS AND METHODS: We performed a secondary analysis of data from a prospective, multicenter study of cardiorespiratory arrest in children. Data were recorded according to the Utstein style. Twenty-eight children (age range: 7 days to 16 years) with cardiorespiratory arrest secondary to trauma were evaluated. The outcome variables were return of spontaneous circulation, sustained (more than 20 minutes) return of spontaneous circulation (initial survival), and survival at hospital discharge (final survival) in relation to the characteristics of the cardiorespiratory arrest and cardiopulmonary resuscitation. Neurological and general performance outcome was assessed by means of the Pediatric Cerebral Performance Category scale and the Pediatric Overall Performance Category scale. RESULTS: Return of spontaneous circulation was obtained in 18 patients (64.2 %), initial survival was achieved in 14 (50 %) and final survival was achieved in three (10.7 %) (two without neurological sequelae and one with vegetative status). Final survival was significantly higher in patients with respiratory arrest (33.3 %) than in those with cardiac arrest (4.5 %), p = 0.04. Final survival was also higher in patients with a duration of cardiopulmonary resuscitation shorter than 20 minutes (27.2 %) than in the remaining patients (0 %), p =0.05. The two survivors without neurologic sequelae had respiratory arrest. CONCLUSIONS: Survival until hospital discharge in children with cardiorespiratory arrest secondary to trauma is lower than that in children with cardiorespiratory arrest. Patients with respiratory arrest when resuscitation is started and those with a duration of cardiopulmonary resuscitation of less than 20 minutes showed better survival than the remaining patients.

Adolescent↗

PubMed2005

[Artificial nutrition in pediatric intensive care units].

OBJECTIVE: To perform an epidemiologic study of artificial nutrition in critically-ill pediatric patients. PATIENTS AND METHODS: A multicenter, prospective and descriptive study was conducted in 23 Spanish intensive care units (ICU) (18 pediatric ICUs and five pediatric/neonatal ICUs) over a 1-month period. Artificial nutrition (AN) was required by 165 critically-ill patients (21.4 %). Data on diagnosis, severity, treatment, type of nutrition administered and complications were analyzed. RESULTS: A total of 54.4 % of the participants were younger than 1 year, 19.4 % were aged between 1 and 5 years old, 15.7 % between 5 and 10 years old and 13.4 % were older than 10 years. ICU mean length stay was 11 days. One hundred six patients were administered enteral nutrition (EN): 67.9 % continuous nasogastric EN, 27.4 intermittent nasogastric EN, 16 % nasojejunal EN, 2.8 % gastrostomy EN. Eighty patients required parenteral nutrition (PN): 86.3 % central PN, 20 % peripheral PN. No significant differences were found between patients with EN and PN in mean energy intake, days receiving AN, diagnosis at admission to the ICU, disease severity (measured by PRISM III) or intensive support techniques. The EN group required greater inotropic support. Patients undergoing mechanical ventilation had equal mortality independent of the type of AN. The most common complications in EN were: 17.9 % emesis, 13.2 % abdominal distension, 11.3 % diarrhea, 4.7 % gastric residual volumes, and 6.6 % hypokalemia. In PN complications consisted of: 5 % catheter related infection, 1.3 % thrombophlebitis, 7.5 % hyponatremia, 3.8 % hypoglycemia, 6.3 % hypophosphatemia and 3.8 % hypertriglyceridemia. CONCLUSIONS: EN provides critically-ill children with adequate energy intake and is well tolerated. Therefore, if there are no contraindications, EN should be the system of choice in the critically-ill patient requiring AN.

Adolescent↗

PubMed2005

[Is high-dose epinephrine justified in cardiorespiratory arrest in children?].

OBJECTIVE: To evaluate the impact on survival of intravenous or intraosseous high-dose epinephrine compared with standard doses in children with cardiorespiratory arrest. MATERIAL AND METHODS: We performed a multicenter, prospective study. Cardiopulmonary resuscitation data from 283 children was collected following international guidelines (Utstein style) over 18 months. In a secondary analysis we studied survival in 92 children who were treated with intravenous or intraosseous epinephrine. RESULTS: One or more conventional doses of epinephrine (0.01 mg/kg) were administered in 12 patients and a first conventional dose followed by one or more high doses (0.1 mg/kg) were administered in 80 patients. The age and weight of children in the conventional-dose group were higher than those in the high-dose group (97.1 +/- 70.5 months vs 29.9 +/- 36.9 months, p = 0.03 and 24.7 +/- 20.8 kg vs 11.9 +/- 8.9 kg, p = 0.037, respectively). The number of doses administered in the conventional-dose group was lower than that in the high-dose group (4 +/- 4 vs 5.4 +/- 3.4, p = 0.01). No significant differences were observed between the two groups in type of arrest, site of arrest, initial electrocardiographic rhythm, response to resuscitation attempts with return of spontaneous circulation, total resuscitation time, neurological status at the end of the episode and survival to hospital discharge and at 1-year of follow-up. CONCLUSION: Although the present study has considerable limitations, the results suggest that high doses of epinephrine do not improve survival in cardiorespiratory arrest in children.

Adolescent↗

PubMed2005

[Effectiveness of activated factor VII in postoperative bleeding after cardiac surgery with extracorporeal membrane oxygenation].

A 4-year-old girl suffered severe postoperative chest tube drainage bleeding after cardiac transplant surgery requiring extracorporeal membrane oxygenation. Transfusions of platelets and fresh frozen plasma failed to decrease the bleeding. At 2.5 hours a dose of 180 mcg/kg of recombinant activated Factor VII was administered. The hemorrhage decreased from 45 ml/kg/h in the first 2.5 hours to 17 ml/kg/h in the next 2.5 hours. The same dose of recombinant activated Factor VII was administered and the hemorrhage suddenly decreased to 1.5 ml/kg/h in the next 2.5 hours, with subsequent disappearance. No adverse events related to activated Factor VII were observed. Recombinant activated Factor VII may be useful in some cases of severe postoperative bleeding in children after cardiac surgery. Randomized controlled studies are needed to confirm its safety and efficacy, and to evaluate the most suitable dose.

Cardiac Surgical Procedures↗

PubMed2004

[Teaching of basic heart-lung reanimation to the general public].

OBJECTIVE: To analyse the efficacy of training in basic paediatric and adult heart-lung reanimation by means of theoretical/practical courses for the general public. DESIGN: Prospective and observational study. SETTING: Chamberi Municipal Health Centre, Madrid. PARTICIPANTS: 360 people aged from 13 to 75. INTERVENTIONS: From 1999 to 2003, 381 people took 26 courses in prevention of accidents and response to them. Theoretical classes in prevention of cardiac/respiratory arrest and in basic heart-lung reanimation (HLR) and practical classes in HLR were given to groups of 5 or 6 students, using dummies of babies, children, and adults. MAIN MEASUREMENTS: At the start and end of the course, 17.2% of the participants were assessed for their theoretical knowledge; and 94.5% had a practical assessment of their HLR skills. At the end of the course all students filled in an anonymous satisfaction questionnaire. RESULTS: In the initial theoretical assessment, the mean score was 3.5+/-1.5 (out of a maximum of 10); in the final assessment, 7.7+/-1.7 (P<.01). 87.2% of participants achieved sufficient practical skills. In the questionnaire, the participants thought the course was very useful for daily life and felt more able to take action. CONCLUSIONS: The basic HLR courses for the general public provide useful theoretical and practical training and manage to improve peoples ability to react correctly and so resolve emergency situations.

Adolescent↗

PubMed2004

[Erythropoietin treatment in critically ill children].

OBJECTIVE: To analyze whether erythropoietin treatment increases hemoglobin and decreases transfusion requirements in critically ill children. PATIENTS AND METHODS: We performed an observational, prospective study of 23 critically ill children aged between 1 month and 6 years. Recombinant human eritropoietin (rHuEPO) was administered at a dosage of 150-750 U/kg/week over 3 days. Hemogram, reticulocyte, iron metabolism, serum ferritin and transferrin were measured before treatment started and weekly thereafter. RESULTS: After erythropoietin treatment, hematocrit, hemoglobin and red blood cells progressively increased, with a maximal response in the sixth week. At the end of treatment, hemoglobin increased 1.68 g/dl, hematocrit by 5 % and erythrocytes 600,000/ml/mm3. Transfusion requirements decreased from 59 transfusions at baseline to 12 in the first week of treatment and none from the sixth week. No treatment-related adverse effects were observed. CONCLUSION: Erythropoietin can be an effective treatment for anemia in some critically ill children, decreasing the number of transfusions and increasing hemoglobin.

Anemia↗

PubMed2004

[Acute renal failure in critically-ill children. A preliminary study].

OBJECTIVE: To analyze the characteristics of acute renal failure (ARF) in critically-ill children and develop a protocol for a multicenter study. METHODS: A prospective, descriptive study was performed in four pediatric intensive care units (PICU) over 5 months. Epidemiological, clinical and laboratory data from children aged between 7 days and 16 years with ARF were analyzed. Premature neonates were excluded. RESULTS: There were 16 episodes of ARF in 14 patients and 62.5 % were male (mean 6 SD age: 50 +/- 49 months). The incidence of ARF was 2.5 % of PICU patients. The most frequent primary diseases were nephro-urological (50 %) and heart disease (31 %). The main risk factors for ARF were hypovolemia (44 %) and hypotension (37 %). Six patients (37.5 %) developed ARF following surgery (cardiac surgery in four, kidney transplantation in one and urological surgery in one). Furosemide was used in 13 patients (as continuous perfusion in nine), inotropes in nine and renal replacement therapy in 12. Medical complications were found in 94 % and some organic dysfunction was found in 81 %. The length of stay in the PICU was 21 +/- 21 days. The probability of death according to the Pediatric Risk of Mortality was 14 +/- 8 %. Five patients died (36 % of the patients and 31.2 % of ARF episodes). CONCLUSIONS: The incidence of ARF in critically-ill children is low but remains a cause of high mortality and prolonged stay in the PICU. Mortality was caused not by renal failure but by multiple organ failure.

Acute Kidney Injury↗

PubMed2004

[Prevalence of mechanical ventilation in pediatric intensive care units in Spain].

OBJECTIVE: To study the prevalence and characteristics of mechanical ventilation in children admitted to Spanish pediatric intensive care units (PICU). MATERIAL AND METHODS: A prospective, multicenter, observational study was performed using a written questionnaire sent to the 46 PICUs in Spain. Clinical data and mechanical ventilation settings in patients undergoing mechanical ventilation on 19th February 2002 were collected. RESULTS: Thirty-three PICUs participated in the study (27 had patients undergoing mechanical ventilation on the study day). The prevalence of mechanical ventilation was 86 patients (45.5 %). The mean age of patients undergoing mechanical ventilation was 36 months and the median was 8 months. Sixty percent of the patients were boys. The main indications for mechanical ventilation were acute respiratory failure (46.5 %), chronic respiratory failure (10.4 %), coma (11.6 %) and postoperative status (10.5 %). Endotracheal tubes were used in 73.2 % and a tracheostomy tube was used in 23.2 %. The most frequent mechanical ventilation modalities used were synchronized intermittent mandatory ventilation (SIMV) in 43 % and control or assisted-control ventilation in 36 %. In 30 % of the patients the duration of mechanical ventilation was longer than 1 month. From the initiation of mechanical ventilation to the study day, pneumothorax developed in 8.1 % of the patients, accidental extubation occurred in 10.5 % and ventilator-associated pneumonia developed in 17.4 %. CONCLUSIONS: A high percentage of children admitted to the PICU requires mechanical ventilation. The most frequent indication is respiratory failure. The most frequently used modality in children aged less than 1 month is pressure SIMV. In children older than 1 month volume-cycled or pressure-limited ventilation and volume-cycled SMIV are used in similar proportions. The prevalence of prolonged mechanical ventilation and the incidence of ventilator-associated complications are very high.

Child↗

PubMed2003

[Effects of prone position, inhaled nitric oxide and surfactant in children with hypoxemic pulmonary disease].

OBJECTIVE: To analyze the therapeutic response to prone position, inhaled nitric oxide (NO) and surfactant in children with hypoxemic pulmonary disease. PATIENTS AND METHODS: We studied the effect of prone position, NO, and surfactant in critically ill children with acute hypoxemic pulmonary disease unresponsive to conventional therapy. We analyzed PaO2, SatO2, the PaO2/FiO2 ratio, oxygenation index and PaCO2 before and after each treatment, as well as the subsequent clinical course. An increase of more than 20 % in the PaO2/FiO2 ratio was considered a positive response. RESULTS: Ninety treatments were administered in 56 patients: 55 patients were treated with NO, 18 with prone position and 17 with surfactant. All three treatments substantially improved oxygenation. The mean increase in the PaO2/FiO2 ratio was 35 % with nitric oxide, 33 % with prone position and 50 % with surfactant. The mean decrease in oxygenation index was 22 % with nitric oxide, 24 % with prone position and 17 % with surfactant. Seventy-one percent of patients treated with NO, 61 % of patients treated with prone position, and 64 % of patients who received surfactant were responders. The three treatments produced a slight decrease in PaCO2 (2.5 mmHg with nitric oxide, 4.7 mmHg with prone position and 5.1 mmHg with surfactant). CONCLUSIONS: Inhaled NO, prone position and surfactant improve oxygenation in some children with hypoxic pulmonary disease.

Adolescent↗

PubMed2003

[Severe hypernatremia: survival without neurologic sequelae].

Hypernatremia is an electrolyte disturbance most frequently caused by excess water loss and less frequently by increased sodium intake. The few reported cases of severe hypernatremia (> 190 mEq/l) had an adverse outcome with high mortality and/or severe neurologic sequelae. The first case was a 7-year-old girl with renal failure undergoing continuous venovenous hemodiafiltration therapy who presented hypernatremia (216 mEq/l) after incorrect preparation of dialysis fluid. The patient was treated with hemodiafiltration and hypernatremia was resolved in 48 hours. She had a convulsive crisis without subsequent neurologic impairment. The second patient, a 3-year-old girl with pseudohypoaldosteronism type I and encephalopathy, had hypernatremia (203 mEq/l) due to erroneous sodium administration, which was corrected in 36 hours with intravenous fluid therapy. Her neurologic status was unchanged by treatment. We conclude that children with extreme hypernatremia survive without neurologic sequelae if treatment achieves a progressive decrease of natremia.

Child↗

PubMed2003

[Octreotide treatment of post surgical chylothorax].

Chylothorax is an infrequent complication of cardiac surgery in children. Most patients respond to a low-fat diet or to parenteral nutrition, but pleuroperitoneal drainage or thoracic duct ligature is sometimes required. We present the case of a 3-year-old girl with Down syndrome and complex atrioventricular canal defect who presented chylothorax 22 days after the Glenn procedure with bidirectional pulmonary-cava fistula. Low-fat diet and parenteral nutrition produced no improvement and the patient was treated with octreotide 1-2 mcg/kg/min in intravenous continuous perfusion, which produced remission of chylothorax. Subsequently, 20 mcg/kg/day of octreotide was subcutaneously administered in three doses, allowing progressive dietary normalization, without recurrence of chylothorax or adverse effects. In conclusion, octreotide is well tolerated and produces few adverse effects. It could be used as a therapeutic alternative in chylothorax refractory to conservative treatment.

Cardiac Surgical Procedures↗

PubMed2003

[Transpyloric enteral nutrition in critically-ill children (I): technic and indications].

OBJECTIVE: To study the utility and efficacy of transpyloric enteral nutrition (TEN) in critically-ill children by analyzing the factors that determine enteral tolerance. PATIENTS AND METHODS: We performed a prospective, observational study between 1994 and 2002 of all critically-ill children admitted to our pediatric intensive care unit who received TEN. The indications for enteral nutrition, type of nutrition and its duration were studied. RESULTS: A total of 286 patients (8.4 % of patients admitted to the PICU in the study period), aged between 3 days and 17 years received TEN. Fifty-five children (19.2 %) were aged less than 1 month and 165 (27.7 %) were aged less than 6 months. Seventy percent received TEN exclusively. The most frequent indication for TEN was mechanical ventilation in 255 children (89.2 %). One hundred seventy-six patients (61.5 %) received TEN in the postoperative period after cardiac surgery. The mean duration of TEN was 15.4 25 days, the maximum volume of nutrition was 118.7 41 ml/kg/day, and the maximum caloric intake was 88.6 26.7 kcal/kg/day. During TEN, 227 patients received sedation (79.3 %), and 124 were administered muscle relaxants (43.3 %), with no increase in complications. CONCLUSIONS: TEN is a useful method of nutrition in critically-ill children.

Adolescent↗

PubMed2003

[Transpyloric enteral nutrition in critically-ill children (II): complications].

OBJECTIVE: To study tolerance to transpyloric enteral nutrition (TEN) and the incidence of secondary complications in critically-ill children. PATIENTS AND METHODS: We performed a prospective, observational study between 1994 and 2002 of all critically-ill children admitted to our pediatric intensive care unit who received TEN. Tolerance and complications were analyzed. RESULTS: Of 286 patients aged between 3 days and 17 years who received TEN, gastrointestinal complications occurred in 13.6 %, abdominal distention and/or excessive gastric residue in 8 % and diarrhea in 6.3 %. Diarrhea was associated with shock (p 0.01), abdominal distension and/ or excessive gastric residue (p 0.008), hypophosphatemia (p 0.001), and duration of TEN (p < 0.001). TEN was discontinued in 2.1 % of the patients because of gastrointestinal complications. Thirty-two patients (11.2 %) died during TEN. No relationship was found between the characteristics of nutrition and complications and mortality. CONCLUSIONS: TEN is a well tolerated method of nutrition in critically-ill children that produces few complications.

Adolescent↗

PubMed2003

[New modalities of mechanical ventilation].

In the last few years new mechanical ventilation modalities have been developed that aim to improve the characteristics of mechanical ventilation and its adaptation to the patient. Volume-programmed and pressure-controlled ventilation (volume-controlled pressure-adjusted, adaptable pressure ventilation, autoflow ventilation) attempt to combine the advantages of volume and pressure ventilation by controlling volume but with decelerated flow. These types of ventilation can be programmed in controlled, assisted, intermittent mandatory ventilation, or support ventilation mode. Other modalities offer pressure ventilation with continuous flow during the respiratory cycle (BIPAP, DUOPAP, APRV) and allow the patient to breathe spontaneously. Some ventilators have new modalities (adaptable support ventilation) that calculate the best minute ventilation according to the patient's weight and the level of support required. The ventilator provides support according to spontaneous respiratory frequency and tidal volume. Other modalities (proportional assist ventilation) provide support according to the patient's respiratory efforts. These new modalities can improve the adaptation of mechanical ventilation to the patient. None of these modalities are superior to the others. The choice of ventilation mode should be individualized according to each patient's characteristics.

Child↗