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Biomedical subjects

J Lafita

Publications and source records attributed to J Lafita.

6 recordsLinked to original sources
PubMed2003

[Physiology and bone physiopathology].

The bone tissue is one of the largest of the organism, with clear functions: to serve as a support and protection for the soft parts, as support for movement with the anchorage of the muscles, as mineral reserve and as interactive storage of the bone marrow. To exercise all these functions the bone must maintain its quality, a concept that combines its degree of mineralisation, its microarchitecture and its capacity to repair lesions, aspects that are included in the broad definition of osteoporosis: "A systemic disease of the skeleton, characterised by a low bone mass and a deterioration of the microarchitecture of the bone tissue, which jointly result in an increase in bone fragility and the consequent increase of the risk of fractures", although from the clinical point of view we have to centre our attention on mineralisation, a quantifiable aspect, understanding as osteoporosis a fall in bone mass greater than 2.5 standard deviations below that of young healthy patients. This article reviews the physiopathological aspects that influence the development of this frequent clinical picture.

Biomarkers↗
PubMed2003

[Secondary osteoporosis].

Secondary osteoporosis is caused by pathologies or medications, differing from the bone loss explainable by the post-menopausal stage or by ageing. The possible pathologies that can condition the loss of bone mass are very varied: endocrinological, digestive, genetic, haematological, rheumatic, post-transplant, pharmacological and a wide miscellaneous group. This article essentially reviews the endocrinological causes, with special emphasis on the more controversial aspects, followed by a clinical approach for the systematic diagnosis of these pathologies, which are frequent in cases initially labelled as primary osteoporosis

Endocrine System Diseases↗
PubMed2002

[Body composition and obesity].

Obesity is a disease that is characterised by a pathological excess of adipose tissue. Normally, this excess is measured according to its repercussion on weight and on the index of body mass. The methods for measuring body composition, some of which are of recent introduction, are showing the consequences on health of excess fat, especially visceral fat. A review is offered of the epidemiological markers of obesity, the techniques for evaluating fatty mass, the influence of the distribution of the adipose tissue and the factors that condition visceral fat, as well as the influence of this tissue on the metabolic profile of the obese patient.

English Abstract↗
PubMed1997

[Weight-loss drugs: composition of diet pills prescribed in Navarra].

BACKGROUND: The prescription, dispensation and sale of "Magisterial formulas" for weight loss is a very extended practice in Spain, in spite of being strongly unadvised by different Administration Department as well as by medical and sanitary groups. The composition of these preparations is not labelled if so only in a generic way. METHODS: The content of 54 capsules from 6 different origins (3 medical consultations, 1 pharmacist consultation, 1 free sale in pharmacies and 1 free sale in stores) was analysed in 2 laboratories. The presence and quantity of 29 active principles was searched by spectrophotometry, chromatography and radioimmunoassay. RESULTS: The presence of some of the 12 following substances was confirmed in 42 samples (77.8%): hormones (levothyroxine, cortisol and cortisone), appetite suppression phenetilamines (amphetamine, amphepranone, fenfluramine and fenproporex), benzodiazepines (diazepam, clorazepato and chlordiazepoxide) and diuretics (triamterene and ciclotiazide). The quantities of active principles was very variable in and among the six groups. In 13 of the capsules 1 active principle and in 29 combinations of two or more was found. None component of the labels, when available, corresponded with their analysed components. In 12 samples (22.2%) none of the which may correspond to some substances different from the 29 sought ones. CONCLUSIONS: The usage of formulas as the studied here on the overweight and obesity treatment should be obviously unadvised.

Anti-Obesity Agents↗
PubMedDate not supplied

[Continuous quality improvement in the control of the type2 diabetes in Navarra. GEDAPSNA study 1996].

Diabetes mellitus type 2 constitutes one of the principal public health problems today, representing an important burden on care and involving extremely high economic costs, both direct and indirect. To provide an adequate response from the different public health systems, the St. Vincent Declaration was drawn up containing certain recommendations on the protocol of care and the carrying out of controls of continuous quality improvement, since it is a chronic pathology that requires a proactive health policy, which prevents, and provides early detection of its complications. In the present work we set out the results of the first study carried out in Navarra on the indicators of quality in the care provided to diabetics in Primary Health care, carried out by the Study Group on Diabetes Mellitus in Primary Care (GEDAPSNA). The study was made of an aleatory sample of 496 patients, by means of gathering data about their clinical records for the year 1996. 12 process indicators and 12 indicators of intermediate and final results were used. The results detect some important deficiencies that require early intervention: lack of exploration and management of the lesions that make up so-called diabetic foot; low achievement of results in the control of arterial hypertension in this group of patients; and absence of exploration of the lesions of the fundus of the eye in more than 50% of type 2 diabetics.

English Abstract↗