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Biomedical subjects

J Lagier

Publications and source records attributed to J Lagier.

7 recordsLinked to original sources

[Difficult blepharoplasties].

UNLABELLED: The effectiveness expected from aesthetic blepharoplasty is strongly related to the attention paid during the preoperative examination. The protocol as well as the proportioning of the surgical gesture are indeed likely to be influenced by the clinical assessment. OBJECTIVES: To emphasize the significant points of the local and general examination that have to be raised in order to reduce the incidence of complications. The delicate situations are detailed and illustrated. The contribution of the complementary investigations and the various surgical strategies are evoked. In the second part are summarized the early and late complications of aesthetic blepharoplasties as well as their management if they could not be avoided.

Blepharoplasty↗

[Necrotizing fasciitis of the eyelids and orbit: a life-threatening ophthalmological emergency].

INTRODUCTION: Necrotizing fasciitis is an extremely serious exceptional infectious process affecting subcutaneous soft tissues with skin gangrene and vascular thromboses. Starting from a case repat of necrotizing fasciitis of the eyelids and orbit, which occurred in a child of 4, we analyse the early diagnostic elements and the urgency of treatment of a pathology which can rapidly be life-threatening. OBSERVATION: A child, aged 4 presented a necrotizing fasciitis of the eyelid and orbit with serious toxic shock, after minor skin abrasion. RESULT: Resuscitation and parenteral antibiotic therapy were not sufficient to stop the necrotizing process, which required surgical debridement of gangrenous tissues. DISCUSSION: Necrotizing fasciitis is a rare affection with fatal local and general prognosis. Location on the orbit and eyelids is extremely rare, with only a score of cases recorded in the literature, principally in adults. Our observation shows the possibility of occurrence in a young child and found the typical features of the pathology: minor initial trauma, beta hemolytic streptococcus, extremely fast progression requiring resuscitation, extensive antibiotic therapy and surgical excision of the gangrenous tissues. Eyesight remained intact, but cases of blindness have been described in the literature. Secondary reconstructive surgery on the eyelids may be necessary. CONCLUSION: Urgent diagnosis of this exceptional pathology that may affect the young child and prompt antibiotic therapy and surgical debridement are the only guarantees of survival of infected patients.

Anti-Bacterial Agents↗

[Primary signet ring cell carcinoma of the eccrine sweat gland in the eyelid. Immunohistochemical and ultrastructural study of a case].

We report a case of a 45-year-old woman who exhibited a primitive eccrine sweat gland carcinoma of the eyelid. Histological study showed cellular proliferation with an Indian file pattern and some signet ring cells with sialomucin secretion. Immunohistochemical study demonstrated these cells to be positive with the anticytokeratin, anti-EMA, anti-HMFG, antiestrogen receptor and antiprogesterone receptor antibodies. Ultrastructural study showed intracytoplasmic vacuoles with numerous microvilli at the apical side. Differential diagnosis with a metastasis from a mammary adenocarcinoma is difficult and a complete staging is necessary to confirm the primitive origin of the tumor. The behavior of this tumor is marked by locoregional recurrence.

Carcinoma, Signet Ring Cell↗

[HIV-positive newborns via maternal-fetal transmission. Early ophthalmic lesions].

Since January 1986, the authors have examined twenty infant HIV positives. In two cases specially, some serious and precocious ophthalmic lesions have been found : an ophthalmic zona appeared at the age of three months, a cytomegalovirus retinitis diagnosed at the age of six months. From this series, the particularities of the HIV infection by maternal-fetal transmission are discussed.

Child, Preschool↗