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Biomedical subjects

J Lamote

Publications and source records attributed to J Lamote.

32 records · Page 2Linked to original sources
PubMed1995

Comparison of perindopril and amlodipine in cyclosporine-treated renal allograft recipients.

The objective of this study was to compare the antihypertensive efficacy and influence on renal function of perindopril and amlodipine in cyclosporine-treated renal allograft recipients with mild to moderate hypertension. We conducted a randomized, double-blind, double-dummy crossover trial in ambulatory patients. Four phases were conducted: 2 weeks on placebo, 8 weeks of maintenance (perindopril or amlodipine), and 2 weeks of washout between treatment periods. Ten hypertensive patients with stable renal allograft function transplanted more than 6 months previously and receiving cyclosporine as part of their immunosuppressive regimen were studied. The patients were allocated to perindopril (2 or 4 mg/d) and amlodipine (5 mg/d) in a random sequence. If office diastolic pressure was greater than or equal to 90 mm Hg after 4 weeks, the dosage was doubled and continued for another 4 weeks. The main outcome measures were office and 24-hour ambulatory blood pressure changes after 8 weeks of active treatment and treatment and time effect on glomerular filtration rate and effective renal plasma flow. Perindopril and amlodipine were equally effective in lowering office blood pressure and similarly efficacious for the 24-hour period of the day. Neither drug affected glomerular filtration rate or effective renal plasma flow. Both agents demonstrated equivalent capacity (time x treatment, P = .955) to reverse renal vascular resistance (amlodipine from 0.35 +/- 0.02 to 0.30 +/- 0.02 mm Hg/mL per minute per 1.73 m2; perindopril from 0.36 +/- 0.03 to 0.32 +/- 0.01) (time effect of all treatments together, P = .043).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Therapeutic implication of the decreased intrathyroidal iodine pool after partial thyroidectomy for simple goiter].

The residual intrathyroidal iodine pool has not been theoretically estimated in 65 subjects from Brussels submitted to partial thyroidectomy for simple goitre. The initial pool was found to be 6.28 mg +/- 3.15. The least invasive form of thyroidectomy (lobectomy) would have reduced this pool to approximately 4 mg and subtotal thyroidectomy to less than 0.5 mg. Various observations lead to the conclusion that the critical level of the thyroidal pool that would maintain euthyroidism lies near 2 to 3 mg. It is therefore concluded that a substitution therapy should be recommended after partial thyroidectomy for simple goitre in areas with relative alimentary iodine deficiency.

Goiter↗
PubMed1988

Stimulating effect of pentagastrin on cancer cell proliferation kinetics in chemically induced colon cancer in rats.

Pharmacological doses of pentagastrin or gastrin are known to stimulate cell proliferation in normal colonic epithelium but the growth-promoting effect of gastrin on colon carcinoma is still controversial. In this study morphological parameters were measured to study the effect of pentagastrin (240 micrograms/kg) on the cell proliferation kinetics in experimental tumours. Colon cancer was produced in rats by weekly injections (20 mg/kg b.wt.) of 1.2-dimethylhydrazine for 24 weeks. Tritiated thymidine was given after administration of pentagastrin or the control solution to the animals. 75% of the animals from the pentagastrin group and 66% of the controls had at least one colon cancer. Autoradiographs of the colonic tumors were performed and the percentage of labeled cells in the cancer cell population was determined after counting 4000 to 16,000 cancer cells per tumor. The labeling index for cancer cells in the pentagastrin-treated group (21.49 +/- 1.76%) was higher (P less than 0.01) than in the control group (14.76 +/- 0.66%). In a second study vincristine sulphate (1 mg/kg) was given to the animals 20 h after administering pentagastrin or the control solution. The percentage of arrested metaphases in the tumours was determined after counting 10,000 to 24,000 cancer cells per histological section. Pentagastrin increased (P less than 0.01) the mean metaphase index by 108% (4.9 +/- 0.44% vs 2.35 +/- 0.32%). These data indicate that cell cycle manipulation of colon cancer is possible with hormonal peptides.

1,2-Dimethylhydrazine↗
PubMed1987

Repair of pericardial rupture by abdominal transphrenic approach solely.

The abdominal transphrenic approach enabled us to repair a left lateral pericardial rupture on a polytrauma patient who also had a rupture of the spleen and a retroperitoneal hemorrhage. A pericardial exploration was necessary because of a sudden upper venous congestion syndrome during operation, suggestive of a cardiac tamponade.

Abdomen↗
PubMed1983

DNA synthesis index: higher for human gallbladders with cholesterol gallstones than with pigment gallstones.

[3H]dThd uptake by the gallbladder epithelium was estimated in 33 patients with cholesterol stones, in 13 patients with pigment stones, and in 12 gallbladders without stones. Proliferative parameters were estimated by autoradiography after in vitro incubation with [3H]-dThd. Stones were identified by quantitative infrared spectroscopy. The degree of inflammation of the gallbladder wall was estimated by a histologic scoring method. In the gallbladders containing cholesterol stones the DNA synthesis index (1.39 +/- 0.28%) was higher (P less than .01) than in the gallbladders without stones (0.19 +/- 0.04%). No significant increase in proliferative parameters was found in the gallbladders with pigment stones (0.24 +/- 0.06%). No correlation was found between total stone number, weight or volume, and the DNA synthesis index. No evidence was observed that inflammation could influence the epithelial cell proliferation. Something in the bile of patients with cholesterol stones rather than the physical presence of stones may be the cause of the variations observed.

Autoradiography↗
PubMed1982

Effect of cholecystokinin-octapeptide, caerulein, and pentagastrin on epithelial cell proliferation in the murine gallbladder.

The growth-promoting effect of cholecystokinin-octapeptide, caerulein, and pentagastrin on gallbladder mucosa was investigated in mice. The acute effects on deoxyribonucleic acid synthesis activity was explored with a [3H]thymidine pulse and autoradiography after subcutaneous injection of the polypeptides. The administration of a supramaximal dose of caerulein or of cholecystokinin-octapeptide induced a significant increase (p less than 0.01) in the nuclear uptake of [3H]thymidine by the gallbladder epithelial cells. The injection of pentagastrin had no effect. Implantation of osmotic minipumps was used for the chronic administration of submaximal doses of caerulein or pentagastrin. Using successive [3H]thymidine pulses and autoradiography, increases in labeling (p less than 0.01) and mitotic indices (p less than 0.05) were observed in the caerulein group, whereas pentagastrin had no effect. In addition, a morphometric method was used to determine the total epithelial cell number in the entire gallbladder after chronic administration of the peptides. A significant (p less than 0.01) epithelial cell hyperplasia was observed to occur after caerulein administration whereas pentagastrin given by the same route had no effect on the epithelial cell population. These data indicate that cholecystokininlike peptides promote epithelial growth in the gallbladder of mice.

Animals↗
PubMedDate not supplied

Granulomatous lobular mastitis: a rare chronic inflammatory disease of the breast which can mimic breast carcinoma.

Granulomatous lobular mastitis is a rare chronic inflammatory disease of the breast. The differential diagnosis with malign breast disease is often not easy. In most cases a surgical biopsy is needed for correct diagnosis. Idiopathic granulomatous mastitis is an exclusion diagnosis, based on the demonstration of a characteristic histological pattern, combined with the exclusion of other possible causes of granulomatous breast lesions. There is still no generally accepted optimal treatment. If surgery forms part of the treatment, a conservative approach seems to be adequate in most cases. Another option is a long-term steroid treatment. It is mandatory to exclude infectious causes of granulomatous mastitis before corticoid therapy is started.

Breast Neoplasms↗
PubMedDate not supplied

Bronchoscopic cryotherapy: preliminary experience.

Our preliminary experience with the bronchoscopic application of cryotherapy using rapid decompression of liquid nitrous oxide as cooling agent is reported. Seventeen applications through rigid bronchoscopy in twelve patients were performed. A single cryotherapy session was successful in the debulking of obstructive malignant lesions of the central airways in five patients (four non-small cell carcinoma, one renal cell cancer metastasis), and in the treatment of a capillary haemangioma (one patient). Two sessions were successful in the treatment of a metastatic melanoma (one patient) and benign granulation tissue (one patient). Cryotherapy was also successful in the treatment of early bronchial cancer (carcinoma in situ) in four patients, requiring repetitive sessions in two. There were no complications or side-effects. These preliminary findings confirm the safety and efficacy of bronchoscopic cryotherapy in a variety of airway lesions.

Adult↗
PubMedDate not supplied

[Breast-sparing surgery in T1 breast carcinoma].

31 female patients with a T1 No N1a Mo breast tumour (diameter smaller or equal to 2 cm) were treated by segmental resection with complete axillar dissection, followed by radiotherapy. Chemotherapy was given in any case of axillary lymph node involvement. The mean follow-up period was 44 months. Absolute survival is 100%. One patient (3%) developed distant metastasis, 2 patients (6%) had a loco-regional recurrence and 3 presented with a metachronous tumour in the contralateral breast. 97% of the patients are actually alive and free of disease.

Adult↗
PubMedDate not supplied

[Free perforation of the colon in Crohn's disease].

Free intestinal colonic perforation in Crohn's disease. Free intestinal colonic perforation in Crohn's disease is a serious complication. In reference to the case history of a Crohn patient with sigmoid perforation, a literature survey of free colonic perforations has been given. Only 18 cases of free colonic perforations in Crohn's disease have so far been described in world literature. Pathogenesis, treatment and evolution of this affection have been dealt with.

Adult↗