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Biomedical subjects

J Lange

Publications and source records attributed to J Lange.

At least 19 recordsLinked to original sources
PubMed1979

[Clinical experience obtained from attention to and delivery of pregnant women with diabetes mellitus with insulin treatment required (author's transl)].

Perinatal mortality recorded from 87 patients with diabetes mellitus requiring administration of insulin was 6.66 per cent between 1975 and 1977. The authors' results are compared with those obtained at different obstetric centres and discussed. Optimum regulation of metabolism and full utilisation of all diagnostic facilities available during pregnancy were found to be essential to individual delivery in the closest possible vicinity of the calculated term.

Adult↗
PubMed1978

[Experiences with replantation of large limbs].

From November 1975 to August 1978 26 limb replantations were performed. All 5 lower extremities had to be reamputated. Of the 21 replanted arms 15 healed without major complications, 9 have regained sufficient function up to now; 3 others show signs of reinnervation.

Accidents, Occupational↗
PubMed1978

[Experience with transvenous xeroarteriography in vascular surgery (author's transl)].

The edge contrast pattern in Xeroradiography allows blood vessels to be delineated with highly reduced concentration of radiopaque fluid. The contrast material is injected rapidly into a cubital vein. The brachial arteries are opacified 3--8 sec. and the femoral arteries about 7--15 sec. after the injection is finished. The arteriograms are of good quality which equals direct conventional angiography, if the vessels are not overlayed by bone structures. Thus the popliteal artery can be judged best in lateral view. The indications for transvenous Xeroarteriography are preoperative diagnosis especially in high risk patients, angiographic diagnosis of soft tissue tumors and postoperative control and documentation of vascular reconstruction in the extremities. Transvenous Xeroarteriography is a really noninvasive, painless and easy to handle method whiich allows visualization of peripheral vascular lesions and can be reproduced at short intervals without any risk.

Angiography↗
PubMed1978

[Can ectopic pregnancy be detected by ultra-sound tomography (author's transl)].

During the past eight years ultra-sound scans were carried out on 281 patients with the suspicion of ectopic pregnancy. Diagnostic criteria were established which were designed to minimize false negative results. In 52 cases the clinical suspicion was confirmed by operation. In 46 of these patients ultra-sound signs of ectopic pregnancy were present. Six ectopic pregnancies were not recognized by ultra-sonographies. 73 patients were suspicious of ectopic pregnancy but did not show ectopic pregnancy. The high rate of ultra-sound misinterpretation in ectopic pregnancy is due to the variability of ectopic pregnancy, abortions of intra-uterine pregnancies, abnormalities of the uterus, and adnexal tumours of other etiology. Negative ultra-sound findings do not rule out an ectopic pregnancy since a number of cases with the clinical suspicion of ectopic pregnancy show intact intra-uterine pregnancies. Ultrasonography is a valuable additional diagnostic method in suspected cases of ectopic pregnancy.

Abortion, Spontaneous↗
PubMed1977

[Interpretation of the trace element content of hairs in criminology, toxicology and environmental protection. Experimental migration of metal ions in keratine (author's transl)].

Metal ions of exogenous origin can penetrate into the hair and can be accumulated. Penetration and distribution of metal ions could be examined by means of electron microprobe-analysis. The dependence of the accumulation of different kations on the concentration of these in the surrounding solutions have been determined by atomic absorption spectroscopy. The dimension of accumulation depends on various factors: the chemical nature of the ion involved, its concentration in the solution and the solutions pH-value, the nature of the anions present as well as the nature and concentration of other kations. The distribution of the kations in the hair can be changed by washing with distilled water. The significance of the present physical-chemical experiments with hairs for criminology, toxicology and to environmental protection were discussed in detail. It was shown that the content of zinc in the hair is of predominantly endogenous origin; moreover, a strong accumulation in the hair root took place. The study of the accumulation mechanism should contribute to clarifying other possible accumulation mechanisms. Further information should be expected from extention of these experiments.

Electron Probe Microanalysis↗
PubMed1977

[Surgical treatment of cerebral ischemia. Indications for surgery in carotid artery stenosis (author's transl)].

Reconstruction of carotid arteries should preferably be a prophylactic measure and only in exceptional cases a therapeutic procedure. The best results are seen in stage I (asymptomatic) or in stage II (transient ischemic attacks). Surgical intervention in acute cerebral vascular insufficiency is indicated only with a conscious patient with a negative brain scan and without progressing symptoms (stage III a). In stage IIIb (progressive stroke) and stage IVa (acute completed stroke) operative treatment is contraindicated because of a high mortality rate. In accidents with persisting neurologic symptoms (completed stroke more than 2 weeks old) necessary reconstruction of the contralateral vessel is indicated.

Aged↗
PubMed1977

Synthesis and properties of new cyclic derivatives of succinic acid with anticonvulsant activity.

The synthesis and pharmacological screening of a series of new phenylsuccinimide derivatives are described. Seven compounds of that series elicited a marked anticonvulsant activity. Among the compounds tested, interesting structures were those metasubstituted with bromine, fluorine or trifluoromethyl group. The most interesting drug seems to be the N-morpholinemethyl derivative of mbromophenylsuccinimide, which has a long duration of activity, elicits a very strong antipentetrazole action, and gives good protection against maximal electroshock seizures.

Anticonvulsants↗
PubMed1977

[Results of the treatment of lower urinary tract fistulas and stenoses in gynaecology and obstetrics (author's transl)].

The results of the treatment of 40 vesico-vaginal fistulas, 13 uretero-vesical fistulas, 2 ureto-uterine fistulas are 44 lower ureteral stenosis are reported. These developed following operative and radio-therapeutic treatment in gynaecology and obstetrics. The vesico-vaginal fistulas were operated through the vagine according to Fueth-Mayo. Even after failed primary operation a repeat vaginal operation was successful. In uretero-vesical fistulas a spontaneous healing cannot be expected later than 8 weeks after the primary operation and an operation for the fistula is then indicated. The results of 13 operations for uretero-vesical fistulas are described. In 12 cases a uretero-cystoneostomy was performed and in one case Boari plastic was done. Two ureto-uterine fistulas were treated by end to end anastomosis of the ureters which was successful. The treatment of post-operative stenosis of the ureter was primarily conservative and resulted in marked improvement on 18 of 24 cases. In 5 of 6 cases a ureto-cystonestomy or ureterolysis yielded good results.

Female↗
PubMed1976

[Investigations on the accumulation of radio-bleomycin in gynaecological tumors (author's transl)].

The indication for treatment with Bleomycin in gynaecological tumors is as yet not well defined. At present Bleomycin is primarily used for advanced gynaecological malignancies. Results of our investigations show that the individual affinity of gynaecological tumors to Bleomycin is very variable. In subsequent investigations it should therefore be determined whether the accumulation of radio-Bleomycin and the sensitivity of a gynaecological malignant tumor to Bleomycin therapy show a positive correlation. The probable chances of success of a course of chemotherapy with Bleomycin could then be predicted.

Adenocarcinoma, Mucinous↗