Biomedical subjects

J Langkowski

Publications and source records attributed to J Langkowski.

5 recordsLinked to original sources

PubMed1989

[MRT of extracranial hematomas at 1.5 T using spin echo and gradient echo sequences].

Magnetic resonance imaging (MRI) at 1.5 T was performed in 25 extracranial haematomas using spin-echo (SE) and fast-field-echo (FFE) sequences. The age of the haematomas was in 11 cases less than 2 days and in 9 cases more than 14 days. Fresh haematomas were isointense to skeletal muscle on T1-weighted SE images. With T2-weighted SE sequences, fresh haematomas had high signal intensity on the first day, but became inhomogeneous with predominantly low signal intensity on the following days. Areas of low signal intensity could be demonstrated by T2-weighted FFE sequences already on the first day after bleeding. Subacute haematomas were recognised by their high signal intensity on the T1-weighted SE images. Also with T2-weighted SE and FFE sequences, subacute haematomas showed increasingly high signal intensity. The characteristic appearance of haematomas facilitates their identification with MRI.

Hemarthrosis↗

PubMed1988

[NMR tomography of thoracic aortic dissection].

The results of magnetic resonance imaging in 10 patients with dissection of the thoracic aorta are presented. In 8 patients, the intimal flap was clearly contrasted from flowing blood in both lumina. In 2 patients the lack of phase shift of the intraluminal signal indicated complete thrombosis of the false lumen. Oblique sagittal sections parallel to the aortic arch and coronal sections through the ascending aorta demonstrated the extent of the dissection and provided information about the involvement of the origins of the coronary arteries and the branch vessels of the aortic arch. In 7 patients, the proximal site of communication between both lumina could be localized.

Aortic Dissection↗

PubMed1988

[Segmentation of MR tomograms for quantitative volume estimation].

MR tomography yields better contrasts for soft tissues than other imaging methods. This allows a reliable measurement of the volume of brain structures, in particular for the ventricular system and e. g. structures in hydrocephalic states. Therefore a method is proposed for segmentation and volume estimation of MR tomograms that is implemented via a computer program. This method provides an accurate determination of the volume tested on multiple-slice-images of normal patients and a phantom. The substantial features and possibilities of this program usable for all kinds of structures in MR-tomograms are explained here in detail.

Cerebral Ventricles↗

PubMed1988

[Radioimmunotherapy of solitary liver metastases using intratumor instillation of 131I-labeled monoclonal antibodies--initial results of a clinical study].

Solitary liver metastases (carcinoembryogenic antigen positive) in two patients suffering from colon carcinoma were multifocally injected with 131I-labelled monoclonal antibodies (131I-MAb) against the carcinoembryogenic antigen (CEA). The 131I activity in the metastases decreased biexponentially. The 131I serum concentration declined triexponentially in patient 1 and monoexponentially in patient 2. The radiation dose to the whole tumor volume amounted to 358 Sv and 762 Sv, respectively; the whole-body radiation dose was 87.5 mSv for patient 1 and 39.0 mSv for patient 2. Complications did not occur. Before treatment there had been a volume doubling time of the metastases of 1.5 and 0.9 months, respectively; this contrasts with a constant tumor volume after treatment as observed over the follow-up period of 3.5 and 2 months, respectively. The CEA serum concentration decreased after 131I-MAb instillation within 1.5 and 2.5 months to 66% and 58%, respectively, when compared with values immediately before treatment. On the basis of these results the intratumoral application of 131I-MAb appears in selected cases to be a suitable method of slowing down growth of liver metastases from gastrointestinal tumors.

Antibodies, Monoclonal↗

PubMed1987

[Abdominal pseudotumor as the clinical manifestation of Whipple's disease. T-cell index as an indicator of disease activity and a parameter of the duration of therapy?].

A large nonresectable upper-abdominal tumor in a 61-year-old woman was found to have been caused by inflammatory infiltration and mechanical obstruction of the mesenteric lymph nodes resulting in obstruction to lymphatic flow. Biopsy at the root of the mesentery and of abdominal lymph nodes raised the suspicion of Whipple's disease, a diagnosis confirmed by a small-intestine biopsy. Long-term antibiotic treatment was successful. Quantitative changes in the composition of the T-cell subpopulations at the time of the diagnosis reverted to normal in the course of treatment.

Abdominal Neoplasms↗