Biomedical subjects

J Lanke

Publications and source records attributed to J Lanke.

At least 37 records · Page 2Linked to original sources

PubMed1991

High coronary mortality in cold regions of Sweden.

The hypothesis that cold climate is associated with high coronary mortality in Sweden is tested. Cold exposure was calculated in each of the 284 municipalities of Sweden. There was a significant association between cold exposure and coronary mortality in both sexes in all age groups. The strongest association was found in men aged 40-64 years (coefficient of determination k = 0.39). The decile of men aged 40-64 years who lived in the coldest municipalities had a 40% excess mortality. A significant association was also found between cold exposure and mortality from cerebrovascular diseases. We conclude that there is a strong regional association between cold exposure and high coronary mortality.

Adult↗

PubMed1991

Water hardness does not contribute substantially to the high coronary mortality in cold regions of Sweden.

Earlier studies have shown an association between cold climate and high coronary mortality. The aim of this study was to elucidate in more detail the effect of drinking water hardness on this association. Drinking water parameters were obtained from 259 municipalities in Sweden over a 10-year period. During the same period a 'cold index' was calculated for each municipality. Standardized coronary mortality rates in men aged 40-64 years were used. A negative association was found between water hardness and coronary mortality (coefficient of determination k = 0.080). A much stronger association was found between coronary mortality and cold index (D = 0.389). When coronary mortality was explained by both water hardness and cold index, the association was not significantly strengthened (D = 0.391). Water hardness was negatively correlated with cold index (r = 0.55). We conclude that the association between cold climate and coronary mortality was stronger than that between drinking water hardness and coronary mortality, and that it persisted after stratification for water hardness.

Adult↗

PubMed1991

Smoking habits, sales of fat and antihypertensives fail to explain the high coronary mortality in cold regions of Sweden.

A previous study has shown a strong regional association between cold climate and coronary mortality in Sweden. The present study intended to elucidate further this association, in particular whether or not it could be attributed to smoking, hypertension and fat consumption. The 284 Swedish municipalities were used as units. The outcome was mortality (SMR) from acute myocardial infarction in men aged 40-64. Prevalence of smoking and use of snuff was estimated by interviews. Sales of antihypertensive drugs were used to estimate prevalence of hypertension. Sales of butter and estimates of consumption of saturated fat by interviews were used to estimate the consumption of fat. Weighted determination coefficients (D) were calculated. Apart from the strong association between cold climate and coronary mortality (D = 0.39), an association was shown between fat consumption and coronary mortality (D = 0.22). A weaker association was found between prevalency of snuffing and coronary mortality (D = 0.15) and between sales of butter and coronary mortality (D = 0.10) and the weakest between sales of antihypertensives and coronary mortality (D = 0.06). No association was found between prevalence of smoking and coronary mortality. When the other explanatory factors were added to cold climate in the model no substantial enhancement of the association was achieved. Cold exposure was correlated to the other explanatory factors. To conclude, this study showed that the strong association between cold exposure and coronary mortality was not affected by the regional variation in the estimates of fat consumption, hypertension or tobacco use.

Antihypertensive Agents↗

PubMed1990

A prospective study of first-incidence depression. The Lundby study, 1957-72.

The present study is based on the so-called 1957 Lundby cohort, a geographically defined normal Swedish population of 2612 individuals who were evaluated for mental disorders in 1957 and 1972. The annual age-standardised first incidence of depression, with or without other psychiatric symptoms, all degrees of impairment included, was found to be 4.3 per 1000 person years in men and 7.6 per 1000 person years in women. Up until 70 years of age, the cumulative probability of suffering a first episode of depression was 27% in men and 45% in women.

Age Factors↗

PubMed1989

A semiautomatic image analyzer for cell counts in monolayers. I. Construction, experimental procedure, and precision obtained.

A simple, flexible, low-cost image analyzer system is presented for determination of the total number of cells and the number of viable cells in monolayers of nonconfluent cells. Viable cells were identified and counted using an immunofluorescence method using fluorescein diacetate. Alveolar macrophages from rabbits were used. The different possible counting procedures that could be performed are analyzed. The precision of the method of estimating the cell numbers is indicated by a coefficient of variation of 5%. The experimental procedure is given for a short-term toxicological in vitro test in which the semiautomatic counting procedures can be performed within 1.5 h.

Animals↗

PubMed1989

A semiautomatic image analyzer for cell counts in monolayers. III. Statistical considerations.

The image-analyzing system described in the companion paper (Thorén and Lanke, 1989) is considered from a statistical point of view. Special attention is given to the following applications: simple cell counts, viability estimation, and toxicity estimation. Different estimators are considered, their variances are discussed, and it is shown how to compute standard errors in different situations.

Analysis of Variance↗

PubMed1987

Incidence of anxiety in the Lundby Study: changes over time during a quarter of a century.

2,550 persons from a geographically delimited area in Sweden were examined and described by a team of 4 psychiatrists in 1947. Mental disorders, personality traits, social factors etc. were recorded for all but 1% of the population. Irrespective of domicile the same persons were examined in the same way first 10, then another 15 years later. The incidence of 'Anxiety' up to 60 years of age was 9.9% in men and 19.7% in women. The majority of both sexes had their first episode as young adults or in the younger middle age (30-39 years). Among men with a 'severe and medium' impairment, the cumulative probability of disease was higher in the 15-year period 1957-1972 than in the 10-year period 1947-1957.

Adolescent↗

PubMed1987

Mode of inheritance as indicated by one-sided and two-sided familial taint: with an application to schizophrenia.

Among his various approaches to an understanding of schizophrenic inheritance, whether dominant or recessive, Rüdin (1916) also compared the respective frequencies of one-sided and two-sided familial taint. Essen-Möller (1949) tried the idea on another sample, but neither of us arrived at a definite choice. Later on Slater (1966) surprisingly demonstrated that unilaterality is typical not only of dominant but also of polygenic transmission. In the present paper we adjust Slater's computation and, in so doing, accentuate his result. We also find a similar preponderance of unilaterality on a recessive model, and offer an explanation for this. The findings substantially reduce the efficacy of laterality of taint as an indicator of mode inheritance.

Family Characteristics↗

PubMed1986

Predictors of alcoholism in the Lundby Study. I. Material and methods.

In this prospective longitudinal study over 15 years (1957 to 1972) the background factors for those who became alcoholics and those who did not were registered before anybody knew what the outcome would be. The population (2,612 inhabitants) lived in 1957 in a delimited area in the South of Sweden, Lundby. In 1957 nearby everyone (98%) was examined by a single psychiatrist, and again in 1972, irrespective of domicile, by two psychiatrists. Among the men who at the outset did not misuse alcohol, 58 became alcoholics. These alcoholics were compared with the non-alcoholics regarding e.g. personality traits, social factors and interactions between factors.

Adolescent↗

PubMed1986

Predictors of alcoholism in the Lundby Study. II. Personality traits as risk factors for alcoholism.

In 1957 all inhabitants (2,612) in a delimited geographical area, Lundby, were examined by a psychiatrist. Personality traits were scored for each individual. During the following 15 years 58 men became alcoholics (44 who had been 15 years or over in 1957). Among the men who in 1957 were scored 'subsolid in combination with symptom neurosis' the risk of becoming an alcoholic was increased 13.5 to 15.8 times. Protective against alcoholism was 'subvalidity in combination with psychosomatic symptoms'. The men with this combination had their risk decreased 12 times. The prediction of alcoholism depended on which factors and which combinations were used. With a sensitivity of 50% a specificity of almost 90% was reached; with a sensitivity of 60% specificities between 70% and 80% were reached.

Adolescent↗

PubMed1986

Predictors of alcoholism in the Lundby Study. III. Social risk factors for alcoholism.

In 1957 all inhabitants (2,612) in a delimited geographical area, Lundby, were examined by a psychiatrist, and social factors were evaluated for each individual. During the following 15 years 58 men became alcoholics. Among the men who in 1957 were in the age group 0-14 years and belonged to a 'gang', the risk of becoming an alcoholic was 100-fold increased. 'Gang' was also an important factor in the age group 15-24 years. 'Crisis' was an important factor among those over 14, and 'disintegrated environment' in the age group 25-59 years. In the latter age group occupations such as 'entrepreneur', became important as a precipitating factor. 'Married' was the only protective factor found.

Adolescent↗

PubMed1986

U-shaped association between mortality and blood pressure in a thirteen-year prospective study.

The present study was performed to investigate the predictive value of casual blood pressure recordings for mortality in a geographically defined population (n = 1917), for which the primary health care services are responsible. Isotonic regression of blood pressure on age was used to define groups with low, medium and high blood pressure. In the age group 40 to 69 years mortality turned out to be a U-shaped function of blood pressure. In those aged 70 years and over blood pressure appeared to be of less importance as a risk indicator of death. The study has shown that a limited number of subjects in a defined population can be utilized in epidemiological studies of mortality as a function of blood pressure if an appropriate statistical method is used in the analyses, thereby justifying our model for studies in primary health care.

Adolescent↗

PubMed1986

Prevalence and incidence of senile and multi-infarct dementia in the Lundby Study: a comparison between the time periods 1947-1957 and 1957-1972.

In a recent Lundby paper, based on the original 1947 Lundby cohort [Hagnell et al., 1983], we reported a diminishing trend in the incidence of both senile and multi-infarct dementia from the first period of study 1947-1957 to the second, 1957-1972. In the present study we use the total Lundby population, including those who entered the Lundby project in 1957, as a basis for our calculations. The findings indicate no statistically significant changes in the prevalence and incidence of senile and multi-infarct dementia during the observation period 1947-1972.

Age Factors↗

PubMed1985

Both high and low blood pressures risk indicators of death in middle-aged males. Isotonic regression of blood pressure on age applied to data from a 13-year prospective study.

This study was performed to investigate whether a moderately sized population of men (n = 954) living in a geographically defined area could be utilized and give valid results in a 13-year prospective study regarding mortality as a function of blood pressure. Isotonic regression of blood pressure on age was used to define groups of men with low, medium, and high blood pressure. Men aged 40-69 years in both extreme groups showed an excess death risk in comparison with those in the medium group. Thus, mortality appeared to be a U-shaped function of blood pressure in this age group. The mortality ratios of the low and high blood pressure groups vis-à-vis the medium group were higher during the first than during the second half of the observation period. Chronic diseases at the time of the initial examination were more common among men who died in the lowest blood pressure group than among those who died in the medium group. In males aged 70-99 years, blood pressure appeared to be of less importance as a risk indicator of death.

Adult↗

PubMed1985

Prevalence of age psychosis and mortality among age psychotics in the Lundby Study. Changes over time during a 25-year observation period.

It has been suggested that persons suffering from age psychosis have benefited from social and medical improvement in the society so that they live longer with their illness than they did before. The Lundby cohort comprises 3,563 persons from a total population, followed concerning mental disorders for 15 or 25 years. In the present study we have investigated the changes over time concerning prevalence of age psychosis and mortality among age psychotics in the Lundby Study during the 25-year observation period. When the first 10-year period was compared with the second 15-year period, the figures for average prevalence of age psychosis and death risk associated with a diagnosis of age psychosis had generally decreased in both sexes, but the differences found between the two time periods did not reach statistical significance. A significantly lower mortality during the second time period was found among mentally healthy women.

Aged↗

PubMed1985

Mortality and age psychosis in the Lundby Study: death risk of senile and multi-infarct dementia. Changes over time in a prospective study of a total population followed over 25 or 15 years.

Persons suffering from age psychosis are known to have a high mortality rate. During the last decades there has been a general improvement in the standard of living and the availability of medical resources for the elderly in most western countries. It has been suggested that persons with a diagnosis of age psychosis have benefited from these changes and live longer with their illness than they did before. The Lundby cohort comprises 3,563 persons from a total population followed concerning mental disorders (psychiatrically treated as well as untreated) for 15 or 25 years. In the present Lundby Study we have calculated the changes over time concerning death risk among persons with senile and multi-infarct dementia and overmortality associated with these two main subgroups of age psychosis. We found that the prognosis in terms of mortality had not undergone any statistically significant change during the 25-year period 1947-1972 among persons in the Lundby cohort with a diagnosis of senile and multi-infarct dementia.

Aged↗

PubMed1984

The overall mortality rate in patients with total hip arthroplasty, with special reference to coxarthrosis.

The mortality rate was calculated in 1385 patients with total hip arthroplasties compared with the population at risk in the period from 1968 to 1981. In elderly women with coxarthrosis, after the age of 70, the mortality rate decreased after the first postoperative year. There was no such effect in men. In women, there were no changes in mortality rate in those who had had revision operations, whereas in men operated on for coxarthrosis who were over the age of 70, there was an increased mortality rate after the first postoperative year following revision. Patients operated on for complications after hip fracture and/or rheumatoid arthritis had an increased mortality rate after the first postoperative year, including both women and men below age 70.

Adult↗

PubMed1983

Current trends in the incidence of senile and multi-infarct dementia. A prospective study of a total population followed over 25 years; the Lundby Study.

Organic brain syndromes among the elderly have been studied prospectively in a total population during the 25-year period 1947-1972. The population (2,550 persons) originates from a geographically delimited area in southern Sweden (Lundby). The original population has been followed for 25 years irrespective of domicile. A comparison of incidences for the first 10-year period (1947-1957) and the second 15-year period (1957-1972) shows a decrease in organic brain syndromes in the population concerning multi-infarct as well as senile dementias.

Adolescent↗