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Biomedical subjects

J Laperrière

Publications and source records attributed to J Laperrière.

18 recordsLinked to original sources
PubMed1995

Technetium-99m-sestamibi prone scintimammography to detect primary breast cancer and axillary lymph node involvement.

UNLABELLED: The purpose of this study was to evaluate prospectively the sensitivity and specificity of scintimammography in the detection of both primary breast cancer and axillary lymph node involvement. METHODS: Sixty-five consecutive women referred for a suspicious breast lesion on clinical examination and/or with abnormal mammographies suggestive of malignancies were studied with scintimammography using planar prone imaging (with a chest positioning device with semicircular lateral aperture on the imaging table) performed 15 min postinjection of 25-30 mCi 99mTc-sestamibi. Three planar views, right and left lateral prone and anterior supine thoracic views, were obtained (8-10 min/view). The entire breast and ipsilateral axillary region were included in the field of view. Excisional breast biopsy and/or fine needle aspiration cytology were performed in all patients within 4 wk after scintimammography. Axillary node dissection was also performed. RESULTS: The largest primary tumor measured 2 x 3 cm. There were 47 primary breast cancers (8 different histologic types) and 18 benign breast lesions (5 histologic types). The sensitivity of scintimammography for detecting primary breast cancer was 91.5% (43 true-positive, 4 false-negative) and the specificity was 94.4% (17 true-negative, 1 false-positive). Metastatic axillary lymph node involvement was seen in 19 of 41 patients. The sensitivity of scintimammography to detect metastatic lymph nodes was 84.2% (16 true-positive, 3 false-negative) and the specificity was 90.9% (20 true-positive, 2 false-positive). CONCLUSION: This preliminary study confirms the results of some previous reports, which showed the high diagnostic accuracy of scintimammography in detecting breast cancer. This study also shows the potential value of this procedure to detect axillary lymph node involvement as concomitant information.

Axilla↗
PubMed1993

HLA class II polymorphism and IDDM susceptibility in the Greek population.

The frequencies of HLA-DQA1, DQB1 and DRB1 alleles were compared between 50 Insulin-Dependent Diabetes Melitus (IDDM) patients and 49 healthy controls in the Greek population. Statistically significant difference in the frequencies of HLA-DQA1*0501-DQB1*0201 (P = 10(-4)), DQA1*0301-DQB1*0201 (P = 0.01) and DQA1*0301-DQB1*0302 (P = 0.001) were observed. The DRB1*0405-DQA1*0301-DQB1*0201 was the only DR, DQ combination significantly associated with the disease. The unexpected increase of DRB1*0405 observed in the Greek IDDM may suggest as reported in Chinese and Japanese IDDM a contribution of DR beta and DQ alpha in susceptibility. Moreover, in contrast to the Asians, in the Greek, the DR beta, DQ alpha are found with the usual DQ beta 57-ve.

Adolescent↗
PubMed1991

Ubiquitin is a component of polypeptides purified from corpora amylacea of aged human brain.

Corpora amylacea (CA) are one of the conspicuous features of brain tissue in normal aging and neurodegenerative diseases. Quantitative protein determination of purified CA revealed a protein content of about 4% of total weight. Qualitative protein analysis revealed a broad range of polypeptides, with four being more abundant. High performance liquid chromatography (HPLC) fractionation of this protein material showed four peaks which are related to the four major polypeptides with molecular weights of 24 KD, 42 KD, 94 KD, and 133 KD. Amino acid content analysis of the 24 KD, 42 KD and 94 KD polypeptides indicated that distinct protein species are involved. N-terminal amino acid sequence analysis of the 24 KD and 42 KD polypeptides revealed in both cases homology with the N-terminal sequence of human ubiquitin.

Aged↗
PubMed1988

Pyocolon: an unusual manifestation of colon ischemia.

An unusual manifestation of a large bowel ischemia was observed in two patients. Both had a left flank tubular fluid collection demonstrated respectively by computed tomography (CT) and ultrasonography (US). At surgery, pyocolon (i.e. ischemic, dilated large bowel segments filled with pus) was discovered and resected. Pyocolon should be suspected in patients with ischemic colitis and sepsis. US, although useful, may be misleading; CT is the investigation of choice to establish the diagnosis.

Aged↗
PubMed1986

Renal cell carcinoma presenting as multilocular cystic mass.

We report a case of a multilocular cystic mass that was erroneously labeled multilocular cystic nephroma at ultrasound and computerized tomography, thus leading to a partial nephrectomy; however the final histologic diagnosis was a multilocular cystic renal cell carcinoma. Only 1 similar case has been reported previously. The radiologic and surgical implications are discussed.

Carcinoma, Renal Cell↗
PubMed1986

[Inflammatory aneurysm of the aorta. Value of x-ray computed tomography and ultrasonography in the diagnosis of a case and review of the literature].

Until recently inflammatory aneurysm of the aorta was discovered only at the time of surgery and confirmed by the pathologist. New imaging modalities, such as ultrasound and CT-scan now enable the radiologist to diagnose this entity before surgery, thus leading to a better surgical planning and reducing the operative morbidity. The authors report a case of inflammatory aneurysm of the aorta and review the literature on this entity.

Aged↗
PubMed1982

Narrowband teleradiology.

A narrowband communication system using the Canadian satellite ANIK-B was used to transmit radiographic images from northern Quebec to Montreal. This slow scan television (SSTV) system was used to study the accuracy of the radiologist's interpretation, both with samples of pre-selected films and current patients. Several hours of training in the technique of radiographic interpretation from a static image displayed on a TV monitor was an important factor affecting performance. In selected patients, based on a sample of 124 error-free direct viewing interpretations by four radiologists, SSTV reading by the same fully trained radiologists was correct in 84.5%. With actual patients, and assuming the interpretation from direct viewing to be the correct one, SSTV reading of the radiographs by the same radiologist gave a corresponding figure of 84.1% in a sample of 518 patients containing 73.4% of negative findings, and 89.4% in another sample of 305 patients, including 82% of negative findings. The present error rate on SSTV reading is twice as great as radiographic interpretation using a broadband television system.

Canada↗
PubMed1979

Lower urinary tract trauma.

Twenty-eight patients with lower urinary tract injuries were reviewed at Hôtel-Dieu de Montréal. Eighteen involved the urethra and ten involved the bladder. Pelvic rami fractures are the main cause of bladder rupture, including almost all cases of extraperitoneal bladder rupture. Pelvic fractures are also the main cause of posterior and bulbo-menbranous urethra rupture. Endoscopy and indwelling catheter insertions follow in importance. Rupture of the bladder can be either extraperitoneal (80%) or intraperitoneal (20%). Ruptures of the urethra involve mainly the posterior and bulbo-membranous segments of the urethra. Post-traumatic strictures nevertheless affect the anterior segment more commonly. In all suspected cases of injury involving the lower urinary tract, retrograde urethrography should be done first, followed by retrograde cystography if indicated. A good knowledge of the relationship of the anatomic compartments is essential to the assessment of communicating injury.

Female↗
PubMed1978

Urethral valves as a cause of dilated Cowper's glands and perineal pain.

Symptoms of lower urinary tract obstruction are the most frequent manifestation of congenital posterior valves. A case is presented in which the initial symptom was perineal pain. Diagnosis was delayed because of a false diagnosis of prostatitis. Urethrography and cystography showed posterior urethral valves and dilated Cowper's glands. Bilateral incisions of the valves with the knife electrode resulted in disapperance of the pain and regression of the dilated Cowper's glands.

Adult↗