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Biomedical subjects

J Laursen

Publications and source records attributed to J Laursen.

10 recordsLinked to original sources
PubMed1988

Nimodipine treatment of subarachnoid hemorrhage.

In a pilot study of 6 patients with subarachnoid hemorrhage caused by a ruptured intracranial (grade IV (Hunt and Hess) aneurysm the hemodynamics and plasma-nimodipine concentrations have been observed during a 3-week period of treatment. We found that 3 patients developed reversible hypotension during the nimodipine treatment and that the hypotension tendency could be related to the plasma-nimodipine level and not to a more or less severe sensitivity to nimodipine. Repeated measurements of blood pressure, plasma-nimodipine and regional cerebral blood flow (rCBF) are necessary for the purpose of obtaining the optimum treatment and for evaluating the effect of treatment.

Adult↗
PubMed1987

Spinal epidural hematomas.

During the period 1943-1985 six patients were operated for spinal epidural hematomas at the department of neurosurgery of the University Hospital of Arhus. It is essential to perform acute laminectomy in case of rapidly increasing neurological symptoms. In the case of slowly increasing symptoms operation may provide a good result even if it is performed a week after the onset of symptoms. It is important to watch patients with fracture/dislocations of the spine closely during the first weeks after a trauma. If they develop neurological symptoms the patients should immediately be transferred to the department of neurosurgery with a view of

Accidental Falls↗
PubMed1987

Elements in normal and cirrhotic human liver tissue. II. Potassium, sulphur, chlorine and bromine measured by X-ray fluorescence spectrometry.

Elements (K, S, Cl, Br) were measured by X-ray fluorescence spectrometry in normal liver tissue obtained at autopsy from 74 subjects (44 male, 30 female), median age 62 years (range 20-87), and in cirrhotic liver tissue from 27 subjects (14 alcoholic, 13 non-alcoholic cirrhosis). The element content (median and 5-95 percentile interval) in normal livers in mmol/kg dry tissue was: K, 198.75 (150.95-256.42); S, 147.60 (73.86-233.97); Cl, 98.73 (69.51-163.55); Br, 0.1101 (0.0701-0.4205). None of the elements displayed any sex difference. There were correlations between the content of Br and Cl (r = 0.26, P less than 0.05) and Br and K (r = 0.24, p less than 0.05). In both groups of cirrhotic livers, K, S and Cl content was within the normal range. Median Br content was above normal both in alcoholic (0.2265 mmol/kg, P less than 0.01) and non-alcoholic cirrhotic livers (0.2228 mmol/kg, P less than 0.01).

Adult↗
PubMed1986

Chronic facial pain following diseases affecting the maxillary antrum. The influence of peripheral impulses from the maxillary air sinus is not significant in their maintenance.

For the purpose of examining the significance of a pain focus in the maxillary air sinus denervation of the mucosa of the sinus by transantral maxillary nerve section was performed. The material comprises 20 patients with pain in the distribution of the infraorbital nerve and previous disease of the relevant sinus. All patients had been treated previously without any benefit from peripheral surgery of the infraorbital nerve. Only 20% had any benefit of the proximal avulsion for more than three months. It is concluded that impulses from the mucosa of the maxillary sinus do not play any part in the occurrence or persistence of facial pain in this highly selected material.

Adult↗
PubMed1986

Trace elements in normal and cirrhotic human liver tissue. I. Iron, copper, zinc, selenium, manganese, titanium and lead measured by X-ray fluorescence spectrometry.

Trace elements (Fe, Cu, Zn, Se, Mn, Ti, Pb) were measured by X-ray fluorescence spectrometry in normal liver tissue obtained at autopsy from 74 subjects (44 male, 30 female), median age 62 years (range 20-87), and in tissue from 27 cirrhotic livers (14 alcoholic, 13 non-alcoholic cirrhosis). The element content (median and 5-95 percentile interval) in normal livers in mmol/kg dry tissue was: Fe, 16.51 (7.82-39.03); Cu, 0.378 (0.189-0.629); Zn, 4.01 (2.59-9.33); Se, 0.018 (less than 0.004-0.035); Mn, less than 0.055 (less than 0.055-0.237); Ti, less than 0.146 (less than 0.146-0.919); Pb, less than 0.0005 (less than 0.0005-0.0154). Only copper content showed a sex difference, being higher in males than in females (P less than 0.04). In both groups of cirrhotic liver, Fe content was within normal, Cu content above normal (P less than 0.05, P less than 0.02), and Se content below normal (P less than 0.0001, P less than 0.04). Alcoholic cirrhotic livers had lower Zn levels (P less than 0.02), higher Mn levels (P less than 0.06), and higher Pb levels (P less than 0.03) than normal livers.

Adult↗
PubMed1983

Iron, copper, zinc and selenium in human liver tissue measured by X-ray fluorescence spectrometry.

The content of iron, copper, zinc and selenium was measured by energy-dispersive X-ray fluorescence (XRF) spectrometry in normal liver tissue obtained at autopsy from 16 females and 12 males 46-87 years old. The precision of the XRF analysis, expressed by the coefficient of variation was: iron, 1.8%; copper, 3.2%; zinc, 1.0%; and selenium, 26.7%. In large liver samples, mean amount-of-substance contents of elements in dry liver tissue were: iron, 16.95 mmol/kg (range 7.90-27.31 mmol/kg); copper, 0.33 mmol/kg (0.08-0.76 mmol/kg); zinc, 5.12 mmol/kg (2.92-9.47 mmol/kg); selenium 0.02 mmol/kg (less than 0.004-0.04 mmol/kg). Furthermore the amounts of iron, copper and zinc were measured in wet-ashed Menghini needle biopsy specimens taken from the centre of 20 large liver samples. There was good agreement between results obtained in biopsy specimens and large samples concerning iron (r = 0.96, P less than 0.001) and zinc (r = 0.97, P less than 0.001), but not concerning copper (r = 0.66, P less than 0.01). XRF analysis appears to be a convenient method for element analysis in liver tissue and for measurement of iron and zinc in needle biopsy specimens.

Aged↗