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Biomedical subjects

J Lazúr

Publications and source records attributed to J Lazúr.

8 recordsLinked to original sources
PubMed1998

[Changes in thrombocyte aggregation in primary hypothyroidism].

The authors examined the thrombocyte aggregation in 10 controls and 17 patients with the diagnosis of primary hypothyroidism before and after 2 months substitution treatment with levothyroxine. They recorded a significantly reduced intensity of the aggregation response in untreated patients as compared with controls after adrenaline (p < 0.01), ADP (p < 0.01) but not after ristocetin. Impaired thrombocyte aggregation was observed in 11 of 17 patients, i.e. in 65%. After treatment the thrombocytopathy improved in 7 of 11 patients (63%), in four it persisted. Except one female patient the thrombocytopathy improved in all patients with manifest hypothyroidism. In patients with the latent form of hypothyroidism probably an independent coincidence of elevated TSH levels and impaired thrombocyte function was involved. The authors did not detect any cases of acquired von Willebrand's disease. In the conclusion the authors mention that impaired thrombocyte aggregation is a frequent phenomenon after thyroxine treatment. It may be of clinical significance when combined with other changes of haemostasis or in conjunction with the use of some drugs.

Adult↗
PubMed1998

[Retroperitoneal hematoma and femoral compression neuropathy--a complication of anticoagulation therapy after myocardial infarct].

Anticoagulant treatment with coumarins is due to it unequivocal benefit and relatively low risk increasingly used for prevention of sudden cerebrovascular attacks, in atrial fibrillation, in the treatment of thromboembolic disease, as part of treatment after replacement of cardiac valves and other diseases. With the increasing number of indications and patients treated with oral anticoagulants the number of haemorrhagic complications is increasing. The submitted case-history demonstrates an uncommon haemorrhagic complication, retroperitoneal haematoma associated with a neurological symptomatology in a 59-year-old patient who had prolonged anticoagulant treatment with monocoumarin with permanent non-rheumatic atrial fibrillation, a history of an anteroseptal myocardial infarction with an aneurysm and apical thrombus, polycythemia and chronic venous insufficiency. In addition to anamnestic data and the clinical picture the final establishment of the diagnosis was significantly assisted by ultrasonography and CT.

Anticoagulants↗
PubMed1992

[A case of systemic mastocytosis].

The authors describe a rare case of systemic mastocytosis without skin infiltration. The first symptom were episodes of flushing in the face and upper trunk. From the case-history it was assumed that the condition had a several year's benign course, the diagnosis was established in the stage of malignant acceleration of the disease from bone marrow biopsy and liver biopsy. Atypical mastocytes displayed metachromasia with toluidine blue and positive naphthol-AS-D chloroacetate esterase. Symptomatic treatment with sodium cromoglycate reduced temporarily the frequency of flushing episodes, but it was not possible to arrest the increase of the mastocyte mass by cytostatic treatment.

Bone Marrow↗
PubMed1992

Hematologic changes in type 2 diabetic patients with various localizations of peripheral vascular disease.

Some hematologic parameters have been measured in 80 patients with Type 2 diabetes mellitus. The patients were divided into three groups: (a) proximal (pelvic and femoral) lower limb macroangiopathy; (b) distal (tibial) macroangiopathy; and (c) control group of diabetics without lower limb macroangiopathy. Mean hemoglobin, hematocrit and fibrinogen values were significantly higher in both the proximal and distal macroangiopathy groups in comparison with the controls. On the other hand, mean leucocyte and platelet counts were significantly elevated only in the proximal macroangiopathy group. Significant correlations were observed in univariate and multivariate analyses between blood fibrinogen concentration and pressure indices expressing severity of lower limb macroangiopathy (ankle/thigh, ankle/arm). In summary, increased levels of hematologic parameters contributing to the increase of whole blood viscosity were observed in Type 2 diabetics with arteriosclerosis obliterans. The observed relationship between fibrinogen concentration and severity of arteriosclerosis obliterans could be an evidence in favor for fibrinogen lowering therapy in this pathologic condition.

Arteriosclerosis Obliterans↗
PubMed1992

[Pulmonary embolism as a rare complication of a contusion in the inguinal region].

In the submitted case-history the authors describe the clinical case of an adolescent patient who developed phlebothrombosis of the right ileofemoral area one year after a blunt injury in the scrotal and right inguinal area. The symptoms of pulmonary embolism were detected sooner than the symptoms of phlebothrombosis. Two-dimensional echocardiography provided valuable information when the authors monitored the dynamics of changes in acute cor pulmonale and the effect of administered treatment.

Adolescent↗
PubMed1990

Different levels of cardiovascular risk factors in type-2 diabetic patients with lower limb proximal and distal vessel macroangiopathy.

The levels of some cardiovascular risk factors (lipids, apolipoproteins and fibrinogen) were measured in groups of Type-2 diabetic patients with lower limb proximal (ileofemoral) and distal (trifurcational) artery macroangiopathy, diagnosed by Doppler ultrasound, and in a group of diabetics without macroangiopathy. The highest mean levels of total and LDL-cholesterol, apolipoprotein B and triacylglycerols were observed in patients with proximal vessel involvement. Significant correlations were found between the thigh/arm index and total cholesterol, LDL-cholesterol, apolipoprotein B and stroke prevalence. On the other hand, a significant correlation was found between ankle/thigh index and fibrinogen. The results of the study suggest that different pathogenetic mechanisms may play a role in the development of ileofemoral and trifurcational vessel disease.

Apolipoproteins B↗
PubMed1989

[Löffler's endocarditis].

The authors describe Loeffler's endocarditis and the treatment of this clinical entity. Among diagnostic methods which drew attention to a cardiac affection associated with eosinophilia, non-invasive examination methods were of decisive importance. They comprised conventional electrocardiographic examination, X-ray of the chest and two-dimensional echocardiography.

Endocarditis↗