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J Lees

Publications and source records attributed to J Lees.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Assessing therapeutic intervention used by NHS Direct nurse advisers.

The National Service Framework for Mental Health has identified NHS Direct as a "new point of access" to appropriate mental health services. Mental health calls account for approximately 4% of all calls received by NHS Direct but raise the greatest level of anxiety among advisers and take twice as long to deal with as other calls. In order to provide adequate advice, it is essential to ensure nurse advisers can deal with this type of call. As a first step in meeting these needs this short research article reports on the types of interventions deployed by 18 nurse advisers during role-plays with a mental health "client" expressing self-harm.

Attitude of Health Personnel↗
PubMedDate not supplied

Long-term effects of acquired aphasias in childhood.

This paper presents the results of study into the long-term effects of acquired childhood aphasia (ACA). Two groups of children, a longitudinal group followed up for at least 2 years (12 children), and a cross-sectional group seen at least 2 years post-onset (12 children) were examined for the severity and pattern of residual language deficits (total 24 children). The results are presented. Overall, these show that more children in group 2 had moderate or severe language deficits at 2 years post-onset than in group 1, in which most children achieved language scores within the normal range by this stage of recovery. These findings are discussed in respect of the educational needs and continuing development of children with acquired aphasias, and the service they require.

Adolescent↗
PubMedDate not supplied

Prostaglandin E2 and fever: a continuing debate.

Prostaglandin (PG) E2 is a potent hyperthermic agent and has been assigned an intermediary function in the response of thermoregulatory neurons to pyrogens. Though attractive, this idea has been challenged on several grounds. The present study confirms that brain PGE2 synthesis increases during fever, the time course of the elevation according with a causative role of the compound. Our experimental data also argue against the involvement of a second cyclooxygenase product, specifically thromboxane (TX) A2, in the action of pyrogens. The sequence of events leading to PGE2 production and fever differs depending on the pyrogen, bacterial vs. leucocytic, and its route of administration. Blood-borne interleukin-1 (IL-1) acts on a discrete site in the central nervous system (CNS) which is tentatively identified with the organum vasculosum laminae terminalis (OVLT). The same site may also be the target for blood-borne endotoxin. In addition, endotoxin may promote PGE2 synthesis in the cerebral microvasculature. Both pyrogens, on the other hand, act diffusely throughout the CNS when given intrathecally. We conclude that PGE2 is well suited for an intermediary role in the genesis of fever and ascribe the reported inconsistencies to methodological factors.

Animals↗