Biomedical subjects

J Leffler

Publications and source records attributed to J Leffler.

30 records · Page 2Linked to original sources

PubMed1992

[Classification of acute pancreatitis in correlation with serum protease levels].

Based on previous work of their own and data in the literature the authors outlined diagnostic and classification criteria of acute pancreatitis. The latter were applied in a prospective study. Thus a group of 71 patients with acute pancreatitis was obtained. In 10 patients of this group at the same time intervals and while the same therapeutic procedures were used, the serum protease levels were followed up. The authors assumed that it will be possible to express thus objectively the severity of the disease and to diagnose in time necrotizing forms of acute pancreatitis. The results re demonstrated the feasibility and suitability of this procedure only for assessment of the severity of the disease.

Acute Disease↗

PubMed1990

[Acute myocardial uptake of lidocaine, mexiletine and amiodarone].

To assess acute myocardial uptake of antiarrhythmic drugs, we measured drug concentrations simultaneously in the aorta and in the coronary sinus during diagnostic cardiac catheterization. Measurements were taken 1, 2, 3, 4, 5, 7, and 10 minutes after intravenous bolus application of lidocaine (n = 10, 25 mg), mexiletine (n = 5, 25 mg and n = 10, 100 mg), or amiodarone (n = 10, 25 mg). Drug levels were measured by high-pressure liquid chromatography. Maximal concentrations were observed after 2-5 min. After 3-5 min coronary sinus levels exceeded aorta levels, indicating the end of net myocardial drug uptake. In contrast to lidocaine and amiodarone, no mexiletine was found in the coronary sinus 15 s after the end of drug application, obviously indicating a high myocardial drug content. Furthermore, the data provide an explanation for the acute efficacy of amiodarone. The myocardial uptake may result in various pharmacodynamic effects of antiarrhythmic drugs.

Amiodarone↗

PubMed1987