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Biomedical subjects

J Legros

Publications and source records attributed to J Legros.

At least 19 recordsLinked to original sources
PubMed2000

On the Earnshaw and the Van den Tempel-Lucassen Compositional Viscoelastic Theories.

We consider a diffusion-controlled solute transfer and discuss the reasons to study the complete convective-diffusive equation to determine the coupling resonant domain between capillary and longitudinal waves in terms of viscoelastic compositional behavior. A perturbation of the surface tension due to solute transfer has two contributions. One is proportional to the surface area change while the other, not considered in the Van den Tempel-Lucassen theory, is due to the surface velocity. Copyright 2000 Academic Press.

Journal Article↗
PubMed1998

Stationary Solutal Marangoni Instability in a Two-Layer System.

The effect of different mass transfer mechanisms on the Marangoni instability in a two-layer system of finite width is studied. A dilute soluble surfactant is transferred across the interface between two immiscible fluid phases. A linear stability analysis is developed, and the corresponding eigenvalue problem is solved analytically for the onset of monotonic instability. Mass transfer is assumed to be controlled by bulk diffusion or/and by the adsorption-desorption mechanism. The influences of the diffusivity ratio and the layer width ratio on the instability of the system are examined. Copyright 1998 Academic Press.

Journal Article↗
PubMed1984

Pharmacological study of pentazocine-naloxone combination: interest as a potentially non abusable oral form of pentazocine.

The hypothesis that co-administration of naloxone would not affect oral but would block parenteral pentazocine's activities was tested in two rat models, the Randall-Selitto and the hypertonic saline writhing tests. A 100:1 dose ratio of pentazocine-naloxone was shown to be optimal and equivalent in oral analgesic effects to pentazocine alone. The same combination, administered parenterally, showed little or no analgesia indicating a suppression of pentazocine activity. Pentazocine-naloxone combination appears, therefore, as a feasible means to retain full analgesic activity of pentazocine when administered orally while any attempt to extract pentazocine from this formulation for intravenous administration would result in little or no pharmacological effect and, therefore, eliminate the potential parenteral abuse of tablets.

Administration, Oral↗
PubMed1983

Effect of vitamin C on acute paracetamol poisoning.

The effects of vitamin C on acute paracetamol poisoning were studied in mice. Given orally at 50, 100 or 200 mg/kg, either simultaneously or 2 h after the oral administration of 875 mg/kg of paracetamol, vitamin C did not cause any decrease in the mortality rate. In similar conditions in previous experiments methionine and cysteine were shown to be very effective antidotes.

Acetaminophen↗
PubMed1979

Post natal side effects in rats induced by hypolipidaemic treatment during pregnancy.

Maternal, foetal and peri- and post-natal toxicity studies of a hypolipidaemic agent, 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl propionic acid (WIN 35833), were performed on different animal species during animal evaluation of this new drug. In teratology studies in rats, mice and rabbits, no adverse effects were detected following drug exposure during the organogenesis period. In peri-natal studies, a neonatal abnormality related to treatment just before term was shown in rats. This modification, previously observed with other hypolipidaemic drugs, seems to be species specific and characteristic of compounds in the aryloxyalkanoic acid series.

Animals↗
PubMed1976

Benorylate interaction with indomethacin and phenylbutazone.

The simlutaneous oral administration of benorylate (4-(acetamido) phenyl 2-acetoxybenzoate) with either indomethacin or phenylbutazone to rats suffering from Freund's adjuvant-induced arthritis leads to an anti-inflammatory effect which is significantly greater than the effect of the same drugs administered alone. Such an additive anti-inflammatory effect is not apparent when the metabolites of benorylate (paracetamol, acetylsalicylic acid) are administered with indomethacin or phenylbutazone. Paracetamol does not increase the anti-inflammatory effect of indomethacin or phenylbutazone and acetylsalicylic acid clearly antagonizes it. The molecule of benorylate itsel is therefore responsible for the additive anti-inflammatory effect. However, if antipyretic activity (yeast-induced hyperthermia) is examined instead of anti-inflammatory activity, the simultaneous oral administration of the different drugs always produces an additive effect. It is concluded that the antagonism between indomethacin or phenylbutazone and non-steroidal anti-inflammatory drugs other than benorylate is present at some receptors but not all. The clinical implications of the results are discussed.

Animals↗