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Biomedical subjects

J Lesage

Publications and source records attributed to J Lesage.

46 records · Page 3Linked to original sources
PubMed1987

Stereotactic administration of intratumoral chronic chemotherapy of recurrent malignant gliomas.

There is a continuous search for more efficient treatment of malignant cerebral gliomas. The work of Penn and Croin demonstrates clearly that survival of rats having experimental gliomas is significantly increased by intratumoral chemotherapy. It has been shown that chronic depth electrodes for the investigation of epileptic patients is a reliable and safe method. Using this proven technology originally developed by Talairach, Szikla and co-workers we have developed catheters for intratumoral chemotherapy. Three patients have been treated. It is premature to pretend that this is a treatment which will lengthen the patient's life. Nevertheless, the feasibility of the technique, its precision and safety are assured. Following this course of treatment, we have seen no deteriorations, no side effects, no bone marrow depressions, and no sign of toxicity. Chemical analysis has shown that cisplatin was delivered to the tumor.

Antineoplastic Agents↗
PubMed1985

[Clinical applications of data processing in psychiatry].

The reduction of computer costs and the introduction of micro- computers have brought about an irreversible change in all the domains of occidental life. Research in the applications of computing in psychiatry has been going on for more than twenty years. The computer can assist the psychiatrist in many areas of his clinical work. This article reviews the applications of computers in domains such as psychological testing, patient interviews, diagnosis, evaluating psychopharmacological and behavioral treatments, evaluating patient progress, education of professionals, and patient and psychic simulation models, simulation which can also be used for education. Problems met when implementing such programs are also discussed; and finally, we explore some avenues of development and make some recommendations.

Computers↗
PubMed1983

Stereotactic biopsy of cerebral space-occupying lesions.

Brain imaging has improved and more and more cerebral lesions are discovered. A direct surgical approach can be dangerous. Stereotactic biopsy appears as an excellent alternative because it provides one not only with a precise histological diagnosis but also gives a real three-dimensional picture of a lesion.

Astrocytoma↗
PubMedDate not supplied

A comparison of solid sampler methods for the determination of hexamethylene-based isocyanates in spray-painting operations.

A polyurethane foam sponge impregnated with 1-(2-methoxyphenyl) piperazine in dimethylsulfoxide was mounted in both cassette and inhalable organic monitor samplers and these were then compared with a dual-filter cassette. The samplers were used for the collection of hexamethylene diisocyanate (HDI) monomer and oligomers during actual spray-painting operations. The dual filter cassettes were positioned on a mannequin. The polyurethane foam cassette (PUF CAS) and polyurethane foam inhalable organic monitor (PUF IOM) samplers were positioned on a cart in the same maximum overspray area. Data from this pilot study suggest that there is no significant difference (P < 0.05, n = 6) in the amount of HDI monomer obtained with the PUF IOM sampler when compared with the amount obtained from the dual filter cassette. The data also suggest that the PUF IOM sampler yields a higher amount of HDI oligomer than either the dual filter cassette or the PUF CAS sampler, neither of which exhibited a significant difference (P < 0.05, n = 6) from each other.

Air Pollutants, Occupational↗
PubMedDate not supplied

[Hypothalamic astrocytoma presenting as obesity with hypogonadism].

We report herein a case of a 30 year old male patient who consulted for a long standing obesity since childhood. Clinical examination reveals the presence of hypogonadism and gynecomastia without galactorrhea. Endocrine assessment showed an hypogonadotrophic hypogonadism with a moderate insufficiency of the adrenocortical axis. Neuro-ophthalmological examination disclosed an inferior bitemporal quadranopsia. MRI showed an extra-axial suprasellar mass, lightly hypointense in T1 and hyperintense in T2. After craniotomy and conservative biopsy, pathological examination of the tumor showed regular cells surrounded with collagen and reticulin marked with immunoperoxidase against S100 protein and GFAP (glial fibrinolytic acidic protein) strongly suggesting the diagnosis of juvenile pilocytic astrocytoma.

Adult↗