Biomedical subjects
Publications and source records attributed to J Ley.
There are various treatments for skin defects. In our study we used a skin-stretching device for the closure of six skin defects of the hand and wrist (Sure-Closure System, Life Medical Sciences, Inc., Princeton, N.J.). Three defects were closed completely. The size of the other three wounds was reduced by 50 to 70%. We saw no complications. The skin-stretching device helped to close skin defects with local sensate tissue.
Potential host sites often present less than optimal dimensions or quality than are required for implant placement. This paper emphasizes a variety of surgical technique designed to optimize these areas. There are a number of anatomic sites available to serve as donors for autogenous bone grafting. They include the tibial plateau, the calvarium, the mandibular rami, the iliac crests and the symphysis of the mandible. Although each has the potential of presenting risks, the symphysis serves a singularly beneficial source. The techniques of harvesting bone, and utilizing it for a variety of grafting procedures is described, the benefits of such utilization are emphasized and the risks of such operations are reviewed.
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The technique for the transfer of implant and abutment position to a working cast has been hindered by multiple transfers and record reproductions. These serve only to delay completion of the patient's prosthetic requirements. A transfer technique that uses custom impression trays fabricated from surgical templates allows for a single-visit transfer of centric occlusion, vertical dimension, tooth position, and implant or abutment location in one procedure. This streamlines treatment and allows for quicker delivery of final prostheses.
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Twenty patient with severe atherosclerotic affection of the lower limbs, but without any symptoms of involvement of their upper extremities, and twenty healthy controls were examined. The investigation included measurement of arterial blood flow and resistance in the left forearm at rest and after a three-minute circulatory arrest, using a strain-gauge venous occlusion plethysmograph. Comparison of the results obtained in each group showed statistically significant differences in haemodynamic parameters such as maximal blood flow, resting resistance, and minimal resistance which suggested the presence of vascular changes also in the upper extremities. Arterial resistance proved to be a more sensitive indicator of circulatory disorder than blood flow.
Glycosaminoglycan (GAG) synthesis and glucose uptake by rheumatoid (R) and nonrheumatoid (NR) synovial cells were studied at the second subculture during four different sets of nutritional conditions and at sequential, defined intervals of the growth cycle. Synovial fibroblastic cells in monolayer cultures secrete both hyaluronic acid and sulfated GAGs in a ratio of about 8 : 1. With increasing cell density the ability to sulfate GAGs appears to decrease. No significant differences in GAG synthesis between rheumatoid and nonrheumatoid lines on a per cell basis could be detected during any interval in the growth cycle. Similarly, no significant differences of glucose uptake per cell could be demonstrated between rheumatoid and nonrheumatoid lines under the various protocols applied throughout the growth cycle. The most important factor determining glucose uptake per cell is the availability of glucose in the medium which is in turn closely correlated with cell number.
The growth kinetics of subcultured human synovial fibroblasts from 16 patients with inflammatory and noninflammatory arthropathies were studied in antibiotic free media. The experimental design allowed a clear distinction between the growth rates and final saturation densities achieved. The effects of refeeding and of the serum concentration were evaluated for each line. Inflammatory lines achieved significantly higher final saturation densities and growth rates than noninflammatory lines for most protocols, but the differences between rheumatoid and nonrheumatoid groups were less marked. Inflammaroty fibroblasts demonstrated a greater independence to nutritional and growth stimulatory factors in their microenvironment than noninflammatory fibroblasts.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.