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Biomedical subjects

J Liddle

Publications and source records attributed to J Liddle.

24 records · Page 2Linked to original sources
PubMed1973

Occurrence of branched-cahin hydroxy fatty acids in Pseudomonas maltophilia.

Three branched-chain hydroxy acids not previously reported in other bacteria were found in extracts from saponified whole cells of Pseudomonas maltophilia. On the basis of evidence from mass spectrometry, infrared spectroscopy, and gas chromatographic procedures, they were identified as 2-hydroxy-9-methyldecanoic acid, 3-hydroxy-9-methyldecanoic acid, and 3-hydroxy-11-methyldodecanoic acid. These acids appeared to be tightly bound to other cellular components since they were not extracted from lyophilized cells with a chloroform-methanol (3:1) mixture.

Bromine↗
PubMedDate not supplied

The relationship between clinical and biochemical changes following neuroleptic treatment in schizophrenia.

Clinical improvement in psychotic symptoms is not immediate when neuroleptic treatment is commenced. Previous studies have demonstrated the development of biochemical tolerance to the effects of neuroleptics on the dopamine system. This study demonstrates a relationship between this biochemical change and the clinical changes occurring in the patients. The results can be explained in terms of dopamine receptor changes in a way that is compatible with the Dopamine Hypothesis for schizophrenia.

Adolescent↗
PubMedDate not supplied

A nonoccupational outbreak of inorganic mercury vapor poisoning.

An outbreak of inorganic mercury vapor poisoning involving 12 people occurred in a trailer park in Mississippi in 1973-74. For information concerning levels of mercury in hair and blood of humans with short-term exposures, these individuals were observed for as long as 10 months after the end of their exposures, and the amount of mercury in their blood and scalp hair was serially measured. Specimens were also obtained from nonexposed individuals in the trailer park. Inorganic mercury was measured in 1-cm segments of hair samples obtained both 6 and 9 months after termination of exposure. Over a 3-month period, the peak amount of inorganic mercury per gram of hair shifted in position from 7 cm to 13 cm from the scalp. The average mercury concentration in newly formed hair (the 4 cm of hair closest to the scalp) decreased fourfold over the same time period. Surface contamination of exposed hair by exogenous mercury also occurred. Levels of inorganic mercury in blood from exposed individuals ranged from 183 to 620 ng/ml and fell to levels similar to those of controls 4 to 6 months after ending exposure. The source of the outbreak was metallic mercury spilled on rugs. Attempts to remove the mercury failed and actually dispersed the metal over a larger surface area. Air mercury levels as high as 1.0 mg/m3 of air were found in one of the contaminated house trailers. Rugs or carpets contaminated with metallic mercury are a significant health risk.

Accidents, Home↗
PubMedDate not supplied

A pilot study of serum polychlorinated biphenyl levels in persons at high risk of exposure in residential and occupational environments.

A pilot study was conducted to determine whether persons at high risk of exposure to three waste sites in the area of Bloomington, Indiana, have abnormally elevated serum polychlorinated biphenyl (PCB) levels. In addition, we attempted to determine which environmental pathways might have contributed most to these exposures. First, a screening questionnaire survey of 995 individuals was conducted; on the basis of these data, 114 of the persons who had the greatest potential for exposure were selected for inclusion in this pilot exposure assessment study. People near these waste sites have higher average serum PCB levels, and a greater percentage have abnormally elevated serum PCB levels, compared with previously characterized populations in the United States. However, we could not distinguish specific pathways of exposure and uptake, with the exception of persons with occupational exposures and, possibly, among persons who reportedly salvaged metal from discarded electrical equipment. Exposures in this community require further evaluation.

Adult↗
PubMedDate not supplied

The views of elderly patients and their relatives on cardiopulmonary resuscitation.

Little was previously known of the factors that may influence patients and relatives when asked to make decisions on cardiopulmonary resuscitation. Attitudes towards resuscitation in general appear to influence the wishes of elderly patients and their relatives for cardiopulmonary resuscitation. Knowledge of the procedure involved in cardiopulmonary resuscitation and its success rate and the patients' sex and health status do not influence their wishes.

Aged↗