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Biomedical subjects

J Liebhart

Publications and source records attributed to J Liebhart.

At least 19 recordsLinked to original sources
PubMed1993

[A comparative study on skin tests and allergen-specific IgE levels determined by enzyme allergo-sorbent testing (EAST)].

Ninety seven randomly selected subjects with bronchial asthma and allergic rhinitis were classified for the comparative studies. The level of allergen specific IgE determined by Enzyme Allergo-Sorbent Testing (EAST) was compared with skin tests. The statistically significant correlation was found for 9 selected allergens. However, the Spearman's rank correlation coefficient values varied largely, depending on a given allergen. They ranged from 0.74 (Dermatophagoides pteronyssinus) to 0.33 (Birch pollen) what might be, in the authors' opinion, a result of Bencard allergens use for skin tests and Kallestad allergens for EAST.

Adolescent↗
PubMed1991

Robust trend analysis in predicting histamine provocation concentration.

Trend analysis is used to predict the histamine provocation concentration PC20 during the so-called challenge test, where increasing doses of the bronchoconstricting agent are given to a patient and the spirometric examination is subsequently performed. Classical least-squares analysis of trends as well as least absolute deviations analysis are compared. The results are interesting and promising from a statistical as well as medical point of view. The methods presented can be applied to many practical problems in medicine.

Algorithms↗
PubMed1990

Robust logistic discriminant functions in diagnosing chronic obstructive airways disease.

The paper gives a comparison of the classical logistic discriminant function, the alpha-trimmed logistic discriminant function and the L1-logistic discriminant function as used for assistance of medical diagnosis in chronic obstructive airways disease. The robustified logistic discriminant functions enable one to obtain higher rates of correctly classified individuals, especially the L1-logistic discriminant function should be recommended.

Discriminant Analysis↗
PubMed1989

Binding of histamine by gastric juice.

Ability of in vitro histamine binding by gastric juice was tested in aspirates from 10 normal subjects, collected during basal acid output (BAO) as well as after pentagastrin stimulation (maximal acid output - MAO). Histamine binding by 1 ml of gastric juice averaged 218.7 micrograms and after stimulation with pentagastrin was about 31% higher.

Adult↗
PubMed1989

Impaired histamine binding by gastric juice of patients with duodenal ulcer.

Histamine binding by gastric juice from 32 patients with duodenal ulcer and 22 control subjects was tested in vitro. The patients had substantially decreased histamine binding both in basal output as well as in pentagastrin stimulated output. The authors suggest that this phenomenon is involved in etiopathogenesis of chronic ulcer disease.

Adult↗
PubMed1987

Objective evaluation of degree of illness with the weighted Mahalanobis distance. A study for patients suffering from chronic obturative lung disease.

An objective evaluation of the state of patients suffering from chronic obturative lung disease is presented. This evaluation is based on the standardized weighted Mahalanobis distance between a patient and a "centre of health". The method works for both continuous and discrete features. The results of the automatic valuation were compared with the ranked physician's evaluation. This was done by the Spearman rank correlation coefficient, which was statistically significant in all computed variants.

Analysis of Variance↗
PubMed1987

The effect of immunotherapy in hayfever patients on histamine binding capacity of blood serum proteins.

Binding of histamine (histaminopexy) by blood serum proteins of 16 hayfever patients was determined before and after treatment with Pollinex. An increase in histaminopexy by 83% in comparison to pretreatment value was observed and it was well correlated with the clinical status of the patients. Participation of this phenomenon in the mechanism of therapeutic effect of specific immunotherapy is discussed.

Adult↗
PubMed1986

Changes of histaminopexy in patients with bronchial asthma and chronic urticaria after histaglobin administration.

In patients suffering from bronchial asthma and chronic urticaria, the value of histaminopexy was determined prior and after histaglobin treatment (3 injections-1 amp. at 7 days intervals). The value of histaminopexy after histaglobin treatment rised over -240% and was well correlated with the clinical effect of the therapy. These observations are considered as an "ex iuvantibus" evidence that histaminopexy may play a role in the etiopathogenesis of allergic disorders.

Adult↗
PubMed1986

Histamine binding proteins identified in healthy subjects and asthmatic patients.

Histamine-binding proteins have been isolated from healthy subjects and patients with endogenous bronchial asthma. Histaminopectic properties were exhibited mainly by IgA, IgG, IgM immunoglobulins, orosomucoid, albumin and ceruloplasmin. Quantitative determination of the identified proteins showed that in the control group immunoglobulins bound histamine in 97.5%, whereas in asthmatics the corresponding percentage (about 81%) was statistically significantly lower.

Adult↗