Biomedical subjects
J Lingard
Publications and source records attributed to J Lingard.
Body fat distribution and total body fat as risk factors for microalbuminuria in the obese.
BACKGROUND/AIM: Despite evidence linking type of obesity with subsequent organ malfunction, such a link with renal malfunction has not been widely researched. The aim of this study was to investigate percentage of total body fat (%TBF), and body fat distribution in relation to the renal function in overweight/obese subjects. METHODS: Body mass index (BMI), waist-to-hip ratio (WHR), TBF (by bioelectric impedance), and albumin excretion rate (AER) were determined in 77 subjects: 48 overweight/obese (BMI > or =27.8 for men and > or =27.3 for women) and 29 controls (BMI <27.8 for men and <27.3 for women). Obese subjects were subdivided into those (n = 33) with central fat distribution (WHR > or =0.81 for women and > or =0.92 for men) and those (n = 15) with peripheral fat distribution (WHR <0.81 for women and <0.92 for men). RESULTS: Obesity, irrespective of type, was significantly related to increased AER. Furthermore, in subjects who did not differ in %TBF, the age-adjusted relative risk of abnormal AER was 18 times greater in centrally obese subjects as compared with controls, while only four times greater in peripherally obese subjects. CONCLUSION: A significant difference in risk of renal malfunction was observed in individuals having the same %TBF, but differing in the distribution of this fat, with a central fat pattern being the greater risk.
Reabsorption of L-glutamine and L-histidine from various regions of the rat proximal convolution studied by stationary microperfusion: evidence that the proximal convolution is not homogeneous.
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Kinetics of L-histidine transport in the proximal convolution of the rat nephron studied using the stationary microperfusion technique.
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