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Biomedical subjects

J Lintermans

Publications and source records attributed to J Lintermans.

24 records · Page 2Linked to original sources
PubMedDate not supplied

Neurotropin effects on stress and performance of airline pilots in simulated flight conditions.

Effects of Neurotropin, an analgesic and antiallergic drug, have been compared to those of an inert, undistinguishable placebo in a double-blind study on twelve experienced Sabena (Belgian national airline) Boeing-737 captains who were requested to operate in unexpected scenarios of emergency and ILS instrument approaches in a flight simulator of their company. The test determined, in both medication groups, a significant increase in heart rates reflecting stress in these experimental conditions. The time course variations of heart rate showed values significantly lower in the Neurotropin group in comparison to the placebo group. Nervosity and workload were subjectively determined by pilots' self-assessment and workload was found lower under Neurotropin. Errors and quality of work, as evaluated by the Sabena Chief Instructor, were not significantly different in both groups. Instrument performances were recorded and analyzed by computer and the concordance between real and ideal flight paths was significantly better in the Neurotropin group. The observed Neurotropin effects of reducing the manifestation of stress and maintaining the pilots' performances might be due to a modulation of CNS monoamines, similar to that observed in animals submitted to Specific Alternation of Rhythm in Temperature (SART) stress model. This finding could be therapeutically relevant to the aggravation by anxiety of chronic pain and allergy.

Adult↗
PubMedDate not supplied

Surgical treatment of subvalvular aortic stenosis. Long-term results.

From 1966 till May 1988, 53 patients underwent surgery for fixed subaortic stenosis. Subvalvular obstruction was isolated in 27 patients (Group I) and associated with aortic valve lesions in 26 (Group II). A membranous stricture was documented in 5 patients and a fibromuscular ring in 48. Excision of the ring and myectomy were performed in all patients, and an associated aortic valve replacement or reconstruction in 7 and 4 patients respectively. There were no hospital deaths. Follow-up evaluation in 50 patients ranged from 6 months to 22 years. Eight patients had to be reoperated upon (1 from group I, 7 from group II): aorto-ventriculoplasty was performed in 3, aortic valve replacement with redo myectomy in 3 and mitro-aortic valve replacement in 2. One of them had 2 reoperations. Functional status at the time of the last outpatient visit was most satisfactory. Continued evaluation remains necessary as obstruction may reappear despite the absence of symptoms.

Adolescent↗
PubMedDate not supplied

Orthotopic heart transplantation eleven years after left pneumonectomy.

Orthotopic heart transplantation was performed in a 21-year-old medical student 11 years after left pneumonectomy for a rhabdomyosarcoma. The cardiomyopathy was the result of the administration of doxorubicin (Adriamycin). The surgical procedure was largely facilitated as a result of an in-hospital donor and the absence of major adhesions. The early postoperative course was mainly uneventful. The patient is doing well 9 months after operation, without any episode of rejection or infection.

Adult↗