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J Lipkowitz

Publications and source records attributed to J Lipkowitz.

4 recordsLinked to original sources
PubMed1983

An experimental model to assess factors associated with scleral buckle infection.

A reproducible rabbit model to assess factors associated with scleral buckle infection was developed. Buckle exoplant material incubated with staphylococcus was sutured to rabbit sclera, covered with conjunctiva, then removed after 24 hours. Colony counts from removed exoplant material were used to define experimentally the degree of infection. Experimental modifications of the model were used to determine how differences in perioperative treatment may affect infection. Soaking sponge exoplant in antibiotic or subconjunctival injection of antibiotic had a marked beneficial effect, while prophylactic topical antibiotic drops, or systemically administered antibiotics had a less marked effect. Silicone sponge exoplant material showed a greater tendency towards bacterial contamination than did solid silicone.

Administration, Topical↗
PubMed1982

Intraocular lenses and experimental bacterial endophthalmitis.

To determine if an intraocular lens renders bacterial endophthalmitis more resistant to therapy, an animal model was developed. Nine rabbits underwent bilateral extracapsular lens extraction with placement of a Simcoe posterior chamber IOL in one eye. Approximately 170 organisms of Staphylococcus aureus were inoculated into both eyes. The eyes of seen animals were treated with intravitreal and subconjunctival gentamicin after 24 and 48 hours. Vitreous cultures remained sterile in all treated eyes for one week after antibiotic therapy. Two animals that did not receive antibiotics showed persistent infection. There was no difference between aphakic and pseudophakic eyes in terms of clinical response or onset of negative cultures.

Animals↗
PubMedDate not supplied

Nummular thioridazine retinopathy.

While thioridazine retinopathy has been well described, the features of nummular thioridazine retinopathy, a unique clinical subset, have been documented in only five previously published cases. This report describes the clinical features in an additional three cases. Nummular areas of retinal pigment epithelial atrophy separated by relatively intact pigment epithelium are found in the midretinal periphery, with sparing of central vision. This entity can occur with doses of thioridazine previously considered safe.

Adult↗