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Biomedical subjects

J Litwin

Publications and source records attributed to J Litwin.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Spontaneous nitroblue terazolium reduction test (NBT) by peripheral blood granulocytes in healthy subjects and in some hematologic syndromes].

The NBT reduction test and determination of alkaline phosphatase activity in the peripheral blood granulocytes (FAG) were done in 94 subjects including 30 blood donors donating blood for the first time and 64 cases of various haematological syndromes. Raised proportion of formazan granulocytes was found in patients with pancytopenia, acute myeloid leukaemia, chronic myeloid leukaemia during blastic exacerbation, Hodgkin's disease during exacerbation and lymphosarcoma. These results correlated with increased FAG activity. Lower proportions of formazan granulocytes capable of spontaneous reduction of NBT were found in patients with chronic myeloid leukaemia, in immunohaemolytic anaemias and in plasmocytoma. Of all the above syndromes only in chronic myeloid leukaemia impaired ability of formazan cell formation parallelled decreased FAG activity. In the remaining syndromes FAG activity in the granulocytes was normal or raised. In the remissions of Hodgkin's disease a fall was observed in the proportion of formazan granulocytes to values of FAG. In chronic myeloid leukaemia the proportion of formazan cells showed considerable fluctuations and no correlation was observed between the proportion of formazan cells and FAG activity.

Alkaline Phosphatase↗
PubMedDate not supplied

[Role of spleen in leukocyte kinetics in dog].

In 9 dogs blood samples were obtained from the splenic vein and artery under general anaesthesia with Eunarcon, the quantitative and qualitative composition of white blood cells was compared and it was found that canine spleen can release or retain granulocytes and mononuclear cells simultaneously or any of these cells separately.

Animals↗
PubMedDate not supplied

Differences in the composition of leucoyctes in the splenic artery and vein in rabbits, and dogs.

Differences in the composition of leucocytes in the splenic artery and vein in rabbits, and dogs. Acta Physiol. Pol. 1975, 26 (1): 33-39. Blood samples were taken from the splenic artery and splenic vein of 14 rabbits and 9 dogs under general anaesthesia (with hexobarbital sodium in rabbits and Eunarcon in dogs) to compare the quantitative and qualitative composition of white blood cells. It was found that the rabbit spleen releases into the circulation mononuclear cells which do not differ in their size from cells of the blood flowing into the spleen, and that it can retain or release granulocytes, probably due to their intravascular margination. The dog spleen can retain or release granulocytes and mononuclears simultaneously or separately, probably due to the mechanism which includes spontaneous contraction of the spleen.

Animals↗
PubMedDate not supplied

[Usefulness of beta-glucuronidase activity determination in the differential diagnosis of acute leukemia].

In 95 cases of acute leukemias the cytochemical type was determined according to Löffler's classification and the activity of beta-glucuronidase was determined in blast cells. In the light of these investigations it was demonstrated that determination of the activity of this enzyme may be useful only in the differential diagnosis and classification of certain cases of acute lymphoblastic or undifferentiated-cell leukaemias.

Acute Disease↗
PubMedDate not supplied

PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease.

14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.

Adolescent↗