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Biomedical subjects

J Loeper

Publications and source records attributed to J Loeper.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Results of leukocyte migration inhibition test against elastin in joint diseases (author's transl)].

UNLABELLED: The purpose of this work was to report the results of the test TML inhibition of leukocytes' migration, using elastin, by Soborg and Bendixen method, modified with elastin rates of 100 micrograms and 200 micrograms/ml, in joints disease. We verified that the test is generally negative in healthy controls (1 TML positive out of 26 cases); we studied 72 patients, and 38 out of them had a positive test. TML is frequently positive in Horton disease, spondylarthritis, rheumatoid polyarthritis without corticoids, collagen disease; in this cases there is a significant difference of migration between patients and controls group. We also noted a positive TML in infections arthritis and other inflammatory but not in joint's diseases with alteration of elastic tissue (scabs and lung's injury). IN CONCLUSION: TML positive test with elastin, is not a specific test of articular injury neither a proof of its immunologic nature but it contributes in diagnostic for joints diseases.

Adult↗
PubMed1980

[Multipuncture: a simple test for cell immunity at the patient's bedside. Determination of a reference population (author's transl)].

Two-hundred and fifty-four hospital patients (125 men and 129 women) treated for neurological or osteo-articular disorders, free from severe underlying diseases, non-atopic and not receiving immunosuppressants were tested for cutaneous delayed hypersensitivity with a multipuncture instrument which measures the response to 7 antigens simultaneously. The purpose of the trial was to determine normal control values in an immunologically normal population. The antigens used were tuberculin, tetanus and diphtheria anatoxins, Candida, Proteus, Streptococcus and Trichophyton. All tests were carried out by the same operator. The subjects were divided into 8 groups according to their sex and age (15-24, 25-39, 40-64 and 65 years or more) and statistical assessment of the results was based on the number and diameter of skin reactions and on individual scores, each score being the sum of mean diameters of all positive reactions observed at 24 and 48 hours. The overall incidence of positive responses was superior to 50%, except for Trichophyton in men and anatoxins in women. Responses were less pronounced in women of all ages than in men, and the number of positive skin tests, as well as the score values, were reduced in subjects aged 65 or more, particularly in males. The population thus tested could serve as reference in further studies using multipuncture.

Adult↗
PubMed1980

[Evolution of serum lipids during the first hours of an acute myocardial infarction (author's transl)].

The evolution of serum lipids is investigated in 26 patients admitted in a coronary care unit less than 9 hours after the onset of an acute myocardial infarction. Blood samplings are made every 3 hours until the 15th hour after the onset of the infarction. The decrease of total serum lipids concentration is significant at the 9th hour (3rd hour : 8,45 +/- 0,58 g/l ; 9th hour : 7,74 +/- 0,36 g/l) ; that of triglycerides, at the 6th hour (3rd hour : 1,33 +/- 0,17 g/l ; 6th hour : 1,18 +/- 0,21 g/l) ; that of cholesterol is more delayed, at the 9th hour (3rd hour : 2,98 +/- 0,18 g/l ; 9th hour : 2,83 +/- 0,11 g/l). The proportion of alphalipoproteins increases, that of prebetalipoproteins decreases, that of betalipoproteins remains unchanged. There is no difference between the patients who received heparin and those who did not. Total lipids and triglycerides concentrations are lower in the group of patients with complications than in the group without complications.

Adult↗
PubMed1980

[Comparative effects of 17 beta-oestradiol and ethinyl-oestradiol on plasma triglycerides in female rats (author's transl)].

Changes in plasma triglyceride levels were observed in female rats after castration and subsequent administration of incremental doses of 17 beta-oestradiol by injection or ethinyl-oestradiol orally. Castration significantly increased blood triglyceride levels and the dose of injected oestradiol which suppressed the effects of castration on vaginal smears and uterine weight also suppressed its effects on triglycerides. However, the oral dose of ethinyl-oestradiol which abolished the effects of castration on the genital tract further increased the levels of triglycerides. Differences in hepatic distribution of the two forms of oestrogen treatment may explain these discordant results.

Animals↗
PubMed1980

[Evolution of serum lipids during the first hours of an acute myocardial infarction (author's transl)].

The evolution of serum lipids is investigated in 26 patients admitted in a coronary care unit less than 9 hours after the onset of an acute myocardial infarction. Blood samplings are made every 3 hours until the 15th hour after the onset of the infarction. The decrease of total serum lipids concentration is significant of the 9th hour (3rd hour : 8,45 +/- 0,58 g/l ; 9th hour : 7,74 +/- 0,36 g/l) ; that of triglycerides, at the 6th hour (3rd hour : 1,33 +/- 0,17 g/l ; 6th hour : 1,18 +/- 0,21 g/l) ; that of cholesterol is more delayed, at the 9th hour (3rd hour : 2,98 +/- 0,18 g/l) ; 9th hour : 2,83 +/- 0,11 g/l). The proportion of alphalipoproteins increases, that of prebetalipoproteins decreases, that of betalipoproteins remains unchanged. There is no difference between the patients who received heparin and those who did not. Total lipids and triglycerides concentrations are lower in the group of patients with complications than in the group without complications.

Adult↗
PubMed1979

[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)].

Cholesterol and triglyceride content of serum lipoprotein fractions isolated by ultracentrifugation have been studied in 33 healthy subjects and in 56 subjects affected by hyperlipoproteinemia of type IIa, IIb and IV. Patients with atherosclerotic disease were characterized by a general decrease of HDL cholesterol and by a negative correlation between HDL cholesterol and VLDL triglycerides; patients with type IIb and IV showed an increase of LDL lipoproteins. The increase of triglycerides in type IIb and IV was caused by elevation of VLDL triglycerides or LDL triglycerides, and the increase of cholesterol in type IIb is sometimes caused by elevation of VLDL cholesterol. It is evident that several subtypes exist within Fredrickson's classification. Patients with cerebral arterial disease when compared with patients affected by non-ischaemic disease, showed a negative and significant correlation between HDL cholesterol and total cholesterol.

Adult↗
PubMed1979

[A case of distal mesenteric arteritis (author's transl)].

A case is reported of distal mesenteric arteritis discovered during operation and confirmed by arteriography. The arteritis was probably not inflammatory in origin, but could have been due to atheroma. Only one other case of this type has been reported.

Arteritis↗
PubMed1979

The antiatheromatous action of silicon.

Silicon is a constituent of connective and elastic tissues. Administered intravenously or per os in rabbits, it inhibits experimental atheromas normally induced by an atheromatous diet, making atheromatous plaques much rarer and lipid deposits more superficial. Though the mechanism of silicon's antiatheromatous action remains shadowy, the impermeability's rise of the arterial wall is probably not the only influencing factor, because the arterial walls of animals under silicon do show a higher lipid concentration with respect to control animals. The preservation of the structure of elastic fibers, as well as of ground substance, and the absence of an increase in oleic acid in the aortic wall may also explain the rareness of atheromatous plaques.

Animals↗
PubMed1977

[The influence of estrogen therapy on triglycerides. Importance of the choice of substance and the route of administration (author's transl)].

The effects of the percutaneous administration of estradiol in circulating lipid levels (triglycerides, cholesterol, total lipids) were studied in 53 post-menopausal women. During treatment, plasma estradiol rose from 20 +/- 15 to 82 +/- 30 microgram/ml, a value identical to that in the normal woman during the follicular phase. Despite this increase in plasma estradion, no increase in blood triglyceride levels was noted. In addition, in the 11 cases where triglycerides were high under basal conditions (1.65 +/- 0.32 g/l) there was a significant fall during the course of treatment from that value to 0.97 +/- 0.16 g/l (p less than 0.001). These changes in triglycerides under the influence of percutaneous estradiol may be contrasted with the hypertriglyceridaemia usually seen in association with the oral administration of synthetic estrogens. The physiopathological implications of these results are discussed.

Estradiol↗
PubMed1977

[Changes in the level of various amino acids in leukemia].

The determination of blood amino-acids by column chromatography has been carried out on 53 patients, 17 with acute myeloid leukemia, 22 with chronic myeloid leukemia. A comparison was made with 25 normal subjects. These determination has shown a significant increase in glycin, cystin and a non significant increase of tryptophan. A positive relationship may exist between uricemia and content of glycin and glutamin, both amino-acids which are messengers of uric acid. A positive correlation has been found between glycin tryptophan and the number of myeloblasts.

Amino Acids↗