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Biomedical subjects

J Lokaj

Publications and source records attributed to J Lokaj.

At least 55 records · Page 3Linked to original sources
PubMed1982

Effect of growth hormone on the metabolic activity of phagocytes of peripheral blood in pituitary dwarfs and acromegaly.

The increase of metabolic activity pf phagocytes estimated by nitrozolium reductase activity is often employed to distinguish between bacterial and non-bacterial febrile disorders. However, false responses has been also observed. The possible role of serum growth hormone in the activation of tetrazolium reductase activity in patients with pituitary nanism or acromegaly was studied. In isolated peripheral granulocytes of pituitary dwarfs the reductase activity was low at resting conditions as well as after starch stimulation of phagocytosis. Two hours after i. m. administration of human growth hormone the resting and stimulated tetrazolium reductase activity was significantly increased (P less than 0.05, and P less than 0.01, resp.). The increase of both activities was found also in patients with active acromegaly. A moderate increase of tetrazolium reductase activity was observed after adding of growth hormone to isolated granulocytes in vitro (P less than 0.01). These results suggest the stimulatory role of growth hormone in regulation of respiratory burst activity of peripheral granulocytes.

Acromegaly↗
PubMed1978

[Primary amyloidosis of the brain in 34-year-old man].

In a male aged 34 dying suddenly with symptoms of cerebral haemoarrhage, amyloid deposits were found in the vicinity of arterioles, venules, small arteries and veins. In the vicinity of lateral ventricles, particularly around the frontal horns, the amyloid formed compact masses macroscopically presenting as grayfish areas showing a distinctly firmer consistency. The perivascular aggregates strongly resembled those occurring in Alzheimer's disease.

Adult↗