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Biomedical subjects

J Lorenc

Publications and source records attributed to J Lorenc.

18 recordsLinked to original sources
PubMed1989

[Disorders of lipid and lipoprotein metabolism in patients with chronic lymphocytic leukemia. I. Preliminary evaluation of lipemia and HDL fractions in various stages of the disease].

The study comprised 128 patients with chronic lymphocytic leukemia (CLL) aged 65.7 +/- 8 years, 59 women and 69 men. Among the patients studied 70 were treated and 58 yet not underwent therapy. The Rai classification of patients with CLL has been used. The control group consisted of 68 subjects aged 56.8 +/- 14 years, 35 women and 33 men, showing no diseases affecting the blood lipid disturbances. The following determinations have been performed in the blood serum: apo B, CH, TG, PL, and CH or PL in the isolated HDL fraction; LDL-CH ratio has also been calculated. In patients with CLL the total CH concentration has been noted which advanced parallel to the disease progress. It resulted first of all from the decrease in LDL-CH (p less than 0.05). Similar alterations have been noted so far as apo B is concerned. It has been demonstrated that the decrease in HDL-CH (p less than 0.05) is also dependent on the disease stage. The simultaneously increasing index HDL-PL/HDL-CH indicate on changes within the HDL2 and HDL3 subfractions suggesting a deficiency of the HDL2 subfraction. The total lipemia and the lipoprotein fraction alterations observed make the diagnostic value of the atherosclerotic threat in patients with CLL doubtful with the use of that parameters.

Aged↗
PubMed1989

[Serum lipids and lipoproteins in patients with cerebrovascular disorders].

In 150 patients with cerebral insult and in 153 subjects of the control group the studies have been performed with an aim to establish the biochemical evaluation of the arteriosclerotic threat. The cholesterol, phospholipid, triglyceride and apo B concentration in the serum as well as quantitative evaluation of the HDL and LDL fractions were involved. The sex-related differences have been found so far as apo B and lipid serum components are concerned. The most characteristic alterations have been showed in the HDL fraction. In the all patients studied the significant decrease in the HDL-CH concentration as well as an increased HDL-PL/HDL-CH index has been noted suggesting changes in the HDL subfraction leading to the diminished concentration of anti-atherogenic HDL2 fraction.

Adult↗
PubMed1989

[Blood lipid and lipoprotein profile in patients in the first week of myocardial infarction].

The serial enzymatic and lipid determinations have been performed in 30 patients with myocardial infarction during the first 6 to 7 days of the disease. During the phase of myocardial infarction development paralel to increasing creatine kinase (CK) activity the increase in the cholesterol (CH) and phospholipid (PL) as well as the increase of HDL and LDL serum fraction (p less than 0.0005) has been observed. At the end of the second day the CK activity normalization has been accompanied by the gradual decrease in the HDL and LDL fraction concentration up to values lower than that at the start of observation (p less than 0.0005). The HDL-PL/HDL-CH coefficient enables the evaluation of changes in the subfraction HDL during the first days of myocardial infarction consisting of HDL2 concentration decrease. Above changes indicate the progressive arteriosclerosis of coronary arteries despite lowering the total CH and the LDL-CH concentration in the serum of patients with acute myocardial infarction.

Adult↗