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Biomedical subjects

J Lubliner

Publications and source records attributed to J Lubliner.

15 recordsLinked to original sources
PubMed1999

Bleeding tendency: a practical approach in dentistry.

The dental profession faces the problems of exaggerated bleeding on a daily basis. The hemostatic, as well as the fibrinolytic processes are better understood today, and the dentist should be familiar with them. The activation of coagulation factors and their clinical expression in the circulation are both described. The most frequently used blood coagulation tests are explained. Antithrombotic medications are frequently used and their implications in dentistry are accentuated. Protocols of prevention and treatment of exaggerated bleeding following dental procedures are included. Among them, the transfusion of clotting factors and the administration of antifibrinolytic medications (tranexamic acid) are recommended for both congenital or acquired bleeding tendencies.

Anticoagulants↗
PubMed1986

Patent ductus arteriosus in premature infants.

An analysis of the course and complications in the ligation of patent ductus arteriosus (PDA) in 30 very low birth-weight preterm neonates was carried out. The mean gestational stage at birth was 26.97 weeks, and median weight was 811 gm. Attempted closures of the ductus with indomethacin in 19 infants failed, although there was temporary closure in nine. Congestive heart failure was present in 29 and respiratory distress syndrome in 22 patients. Endotracheal intubation with ventilation assistance was necessary in the entire series. The mean age at operation was 13.5 days, and ductal ligation was performed in the intensive care unit under local anesthesia, supplemented with pancuronium and pethidine. There were no intraoperative deaths, but five infants died during their hospitalization from unremittent respiratory distress syndrome. There were seven additional late deaths. Eighteen survivors were followed for a mean of 26.5 months. Early ligation of PDA in very low birth-weight prematures improved the cardiorespiratory status, and long-term follow-up revealed good clinical progress in two-thirds of the surviving group.

Journal Article↗
PubMed1985

Ligation of patent ductus arteriosus in very low birthweight premature neonates.

The results of ligation of a patent ductus arteriosus in 30 premature neonates with a very low birth weight were analysed. The mean gestational age at birth was 27 weeks and the mean weight 811 g. Attempted closure of the ductus with indomethacin in 19 infants failed, though there was temporary closure in nine. Congestive heart failure was present in 29 and respiratory distress in 22 patients. Endotracheal intubation with assisted ventilation was necessary in all cases. The mean age at operation was 13.5 days and ductal ligation was performed in the intensive care unit under local anaesthesia supplemented with pancuronium and pethidine. There were no intraoperative deaths, but five infants died in hospital. There were seven late deaths. Eighteen survivors have been followed for a mean of 26.5 months. Early ligation of a patent ductus arteriosus in premature infants with a very low birth weight improved the cardiorespiratory state. Long term follow up showed good clinical progress in two thirds of the surviving group.

Ductus Arteriosus, Patent↗
PubMedDate not supplied

Effects of disopyramide on reperfusion arrhythmias in dogs.

We tested the effect of disopyramide on reperfusion arrhythmias in mongrel dogs. The control group consisted of 27 dogs. Twenty-nine dogs received two intravenous doses of disopyramide (total: 5.3 mg/kg) before and during the occlusion of the left anterior descending coronary artery. The blood levels of disopyramide averaged 3.95 +/- 0.95 micrograms/ml and 5.9 +/- 1.1 micrograms/ml, 2.5 and 9.5 min after the ligation. The incidence of reperfusion arrhythmias was significantly (p less than 0.05) lower in the treated group (7.5%) than in the control group (33.3%). Disopyramide also lowered the incidence of arrhythmias during the occlusion period (14% vs. 52%, p less than 0.01). Both groups showed a correlation between the incidence of arrhythmias during the occlusion period and on reperfusion.

Animals↗
PubMedDate not supplied

Massive arterial air embolism during cardiopulmonary bypass.

Massive arterial air embolism occurred in two patients during 1250 open heart operations. Emergency measures led to complete recovery in both cases. Flow reversal, hypothermia and anti-oedema measures may be adequate in some clinical situations for total recovery after this catastrophic accident.

Cardiopulmonary Bypass↗
PubMedDate not supplied

Cardiac tamponade and central venous catheter.

Two patients survived after emergency surgery for cardiac tamponade which was caused by a central venous catheter perforating the right atrium and the right ventricle. A review of the literature shows 19 reported cases with only two survivals. The possible causes and guidelines for safer use of central venous catheters are discussed.

Adult↗