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Biomedical subjects

J M Bailey

Publications and source records attributed to J M Bailey.

At least 235 records · Page 13Linked to original sources
PubMed1966

Mutarotase in higher plants: distribution and properties.

The enzyme mutarotase from mammalian tissues catalyzes interconversion of anomeric forms of glucose and structurally related sugars; it may be involved in transport of sugars. Isolation and species distribution of a similar enzyme in higher plants are described. The enzyme from green pepper (Capsicum frutescens) was purified 230-fold. It differs from the mammalian enzyme in both substrate specificity and lack of inhibition by 1-deoxyglucose and phloridzin.

Arabinose↗
PubMedDate not supplied

Anti-inflammatory drugs in experimental atherosclerosis. Part 5. Influence of cortisone acetate on short-term and long-term cholesterol fluxes in atherosclerotic aorta.

Previous studies in this series have shown that cortisone and other anti-inflammatory drugs inhibit atherosclerotic plaque development in cholesterol-fed rabbits. The present study was designed to investigate the influence of cortisone on the processes of cholesterol influx and efflux in the aorta wall. Forty-seven New Zealand white rabbits were fed a 1% cholesterol diet for periods up to 12 weeks. In addition 23 of the animals were fed 5 mg cortisone acetate daily. At 0, 5 and 12 weeks, groups were fed a tracer dose of [3H]cholesterol. Plasma cholesterol specific radioactivity was measured at intervals during the next 10 days. Total aorta cholesterol and its specific activity were measured by killing groups of animals at 2 days and 10 days. Atherosclerotic plaque intensity at 12 weeks, measured planimetrically, averaged 68 +/- 12% in controls vs. only 6 +/- 3% in cortisone-treated animals. During the period between 5 and 12 weeks, net cholesterol accumulation by chemical analysis averaged only 11 micrograms/g aorta/day in cortisone-treated animals vs. 117 micrograms/g in controls. [3H]cholesterol influx (measured during a brief 2-day exposure) at 5 weeks averaged 206 and 199 micrograms/g tissue/day and at 12 weeks 586 micrograms and 281 micrograms/day in control and cortisone-treated animals, respectively. Measured over a longer 10-day period, however, the apparent influx of [3H]cholesterol was much less in cortisone-treated animals, averaging only 53 micrograms/day compared to 269 micrograms/day in controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Does childhood sexual abuse cause borderline personality disorder?

Several studies have found that women with borderline personality disorder are more likely than controls to report a history of childhood sexual abuse. Researchers have generally assumed that childhood sexual abuse causes borderline personality disorder, but there are other possible interpretations of the association. We surveyed psychologists about the likelihood that patients with various personality disorders would engage in behaviors relevant to several alternative interpretations. Relative to patients with other personality disorders and to the "typical outpatient," patients with borderline personality disorder were rated as especially likely to misinterpret or misremember social interactions, to lie manipulatively and convincingly, and to have voluntarily entered destructive sexual relationships, possibly even at young ages. We discuss the plausibility of relevant alternative interpretations of the association between childhood sexual abuse and borderline personality disorder.

Adult↗