[Surgical treatment of chronic pancreatitis].
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Biomedical subjects
Publications and source records attributed to J M Bellón Caneiro.
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The objective of this study, is to confirm a clear benefit of protein synthesis after administration of branched amino acids in parenteral nutrition solutions. Particularly, on a parenteral total hypocaloric nutrition including lipids. Eighty one digestive surgical patients, were included in this study. Fifty with neoplastic disease and thirty one without. Patients in both study groups received a similar peripheral vein nutritional support regimen one week after surgical treatment. To evaluate the effects of the branched chain amino acid enrichment on total parenteral nutrition, we observed the behavior of short middle life proteins such as transferrin, prealbumin, and retinol binding protein, for their reliability as indexes of protein synthesis.
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The endotely of the vascular wall represents a natural antithrombogenic layer in intimal contact with the bloody flow. The waited success of the artificial prosthesis as replacers of minor vessels was not reached. Basically, its poor results were caused by the lake of endothelialization on the prothesical material. A cellular lap on the prosthesis, previously to the implant, could be a good resolution to this problem. If we studied the possibility to obtain a stable, endothelial monolayer "in vitro" before to the "in vivo" implant of the vascular prosthesis. We studied the role of fibronectin as a mediator between the substract and the endothelial cell. Changes on fibronectin when it is added on the culture medium were also analyzed. Although fibronectin has some positive effects as a biologic "glue" previously to the implant to the prosthesis, our results show that after the implant, fibronectin could cause a toxic effect on the adherence and survival of the endothelial cells.
A clinical study on the incidence of malnutrition among hospital patients with digestive system surgical disease is presented. Eighty-one patients were admitted into this trial and underwent preoperative nutritional assessment, which permitted classifying the type and intensity of malnutrition, in order to develop the appropriate postoperative nutritional support. There was high malnutrition incidence among both cancer and non-cancer patients, reaching levels of 80%.
Presentation of the first results obtained from our study, the objective of which is to discover a benefit in the nutritional state following the administration of a greater amount of branched chain amino-acids in parenteral solutions using the peripheral method, during the first 7 days of the postoperative period, in neoplastic patients subjected to surgery of the digestive tract.
One of the generic indications of parenteral peripheral malnutrition is the immediate postoperative period following surgery of the digestive tract. In the series presented, fifty patients with digestive neoplasia of different locations were studied, with slight or moderate malnutrition upon admittance. After the operation, feeding was done using hypocaloric parenteral solutions for the first seven days of the postop. period. In the qualitative intake of nitrogen in this type of nutrition, branched chain amino acids are important due to their beneficial effects on metabolism, and for this reason two complete hypocaloric solutions containing 45% and 15.5% of these amino acids were administered to each respective group under study. To justify the effect of improving the proteic synthesis attributed to these amino acids, the levels of rapid turnover proteins, transferrin, prealbumin and retinol-binding protein were determined.