Novel thin-layer chromatographic visualization reagent for phencyclidine.
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Biomedical subjects
Publications and source records attributed to J M Bonicamp.
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A method is reported for separating drugs from serum lipids on special thin layer chromatographic media with insertable sample application discs, using a double-development, single dimensional technique. Drugs whose detection normally was precluded by lipid were detected at therapeutic levels using the new procedure.
Psychotropic, ring-substituted amphetamine derivatives can be differentiated from each other and from over-the-counter drugs using a sequential TLC detection technique. The improved detection is accomplished by distinct differences in color through four detection stages. Reported in the tables are Rf values in two solvent systems, the color characteristics through the four detection stages and in two confirmatory reagents, and the minimum detectible concentrations in urine of 19 amphetamine derivatives.
Beta adrenergic blocking agents are readily identifiable in urine using thin layer chromatography. Because of the tremendous current and predicted future use of beta blockers, the presence of the drugs and their metabolites will become commonplace in urine and other biological fluids. A broad-screening system is described that relies on a sequence of four detection stages to differentiate beta blockers from other drugs, including some heart medications. The minimum detectable concentrations in urine of nine beta adrenergic blocking agents, the RF values in one solvent system, and color characteristics through four detection stages of the beta blockers and other common drugs are reported.