PubMed Health⌕ Search

Biomedical subjects

J M Bonnetblanc

Publications and source records attributed to J M Bonnetblanc.

At least 145 records · Page 8Linked to original sources
PubMed1987

[Quinidine-induced lichenoid photodermatitis].

Quinidine-induced lichenoid photodermatitis was definitely isolated by Berger and Sesody in 1982. We had an opportunity to observe 4 cases of this striking clinical condition and encountered some particularities. Our patients (2 men and 2 women) were 60, 64, 81 and 68 years old respectively. All had a previous cardiovascular history; diabetes was also present in patient No. 2, and hypertension in patient No. 4. All patients were taking other drugs. The first patient presented with a 4-year old lichenoid eruption on the hands, associated with some degree of follicular keratosis. The second and third patients had a mixture of mainly lichenoid lesions on sun-exposed areas, but eczematous and desquamative lesions were also encountered. The fourth patient had typical lichenoid photodermatitis with occasional bullae on the arms and legs. In all patients the disease appeared or worsened in the Summer. It disappeared rapidly in 3 cases upon withdrawal of quinidine (patients No. 1 and 2) or hydroquinidine (patient No. 3), but it lasted longer in patient No. 4, with pigmented sequelae. Histological examination of the skin was consistent with a lichenoid eruption in all cases. However, an immunopathological study revealed a pemphigoid-like pattern in patients No. 1 and 2, and ovoid bodies more suggestive of lichen planus in patient No. 4. Photobiology was not performed. A review of the literature showed that the terms "lichen planus", "lichenoid", "lichenification" or "violaceus hue" were frequently encountered, and we suggest quinidine as one of the most common agents of lichenoid reaction.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1987

[Dietary carotenodermias].

Four cases of carotenodermia are presented, secondary to marked ingestion of carotenoid-rich vegetables. The first case was a 34 year old woman who presented with yellow palms and soles while on Weight Watchers diet. Loss of weight was accompanied by irregular menses. The second case was a 21 year old woman with orange palms and soles probably due to lycopenemia by tomatoes rich regimen. The third case is a 52 year old woman with the same type of diet as in case 1, associated with high cholesterol level. The fourth case is a 1.5 year old boy with a high intake of commercially available meals ("petits pots"). All the patients were free of disease usually associated with high level of carotenemia. Irregular menses or amenorrhea may be observed in such cases, either due to the rapid weight of loss, or as a manifestation of psychiatric disorder, and anorexia nervosa is possibly encountered. The toxicity of carotenoids is unproven and others substances ingested with high content vegetables diets are possible answerables.

Adult↗
PubMed1987

Early detection of streptococcal group antigens in skin samples by latex particle agglutination.

The streptococcal group antigens (A to G) were researched in skin biopsy specimens by a latex agglutination technique using commercial (Slidex Streptokit bio-Mérieux and Streptex Wellcome) and experimental reagents. Twenty-seven patients with obvious cutaneous infections (12 cases of erysipelas, nine cases of cellulitis, and six cases of necrotizing fasciitis) and 27 age- and sex-matched controls were studied. Our preliminary data demonstrated the possibility of an early diagnosis of streptococcal cutaneous infections involving the deep dermis and/or hypodermis. We used a latex agglutination technique that is quite specific and gives a better sensitivity (0.63) than either conventional bacteriologic cultures on needle aspiration or skin biopsy specimens.

Adult↗
PubMed1986

[Bullous pemphigoid with pemphigus type antibodies in vivo. 2 cases].

Pemphigus vulgaris, whether of the vulgaris or foliaceus variety, and bullous pemphigoid (BP) are two groups of auto-immune bullous diseases which in most cases can easily be differentiated on the basis of clinical, histological and, mainly, immunopathological data. Like cicatricial pemphigoid, BP may be accompanied with circulating pemphigus-like antibodies (PLA) which are not detected in vivo by direct immunofluorescence (IF). However, a true pemphigus-BP association, as reported first by Chorzelski et al., is exceptional. Two cases of BP immunolabelled with pemphigus-like antibodies at direct IF are reported, raising a discussion on this particular association. The first case concerns a 62-year old man presenting with extensive psoriasis treated with salicylated vaseline and topical corticosteroids. The patients was admitted for a disseminated, symmetrical and pruriginous bullous eruption made up of tense bullae on healthy and psoriatic skin or on an urticarial background, without Nikolsky's sign. Pathological examination of a recent bulla showed subepidermal detachment without acantholysis. Direct cutaneous IF revealed linear labelling of the basement membrane zone with IgG, C3 and C1q, and labelling of the inter-cellular substance of the epidermis with IgG. Indirect IF on O+ human skin demonstrated antibodies of the pemphigoid type (1/128) and of the pemphigus type (1/64). Standard laboratory examinations only showed moderate blood eosinophilia (950/mm3) and a rise in total IgE. Under systemic corticosteroid therapy (prednisone 1 mg/kg/day) and azathioprine (2 mg/kg/day) the bullae rapidly disappeared.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1986

[Pruritus and tardive cutaneous porphyria].

Pruritus was present in one half of our cases and ran parallel to the disease, thereby suggesting a causal relationship between it and PCT. Moreover, no correlations could be established between pruritus and the patients' sex, associated treatments (oestrogens, etc.) or underlying disease (liver damage, diabetes mellitus, cancer, hypersideraemia), nor between pruritus and the form of PCT (sporadic or familial) and the levels of urinary porphyrins. Pruritus localized to sun-exposed skin areas belongs to the category of phototoxic symptoms, although a burning sensation is more often observed in such cases, but this cannot explain the generalized pruritus. Immunoglobulin and complement deposits in the vessel walls have been demonstrated in PCT. In addition, the serum of PCT patients may, when irradiated, activate the classical complement pathway, thus promoting the release of mediators. Pro-inflammatory enzymes probably play a secondary role.

Aged↗
PubMed1986

[Disulon in the treatment of Horton's disease. Experience with 20 patients].

Disulon (Dapsone) was used in 20 patients with Horton's disease, with the object of reducing steroid therapy. In a retrospective series, Dapsone was prescribed in 12 patients with severe complications of steroid therapy; it was possible to reduce the dose of steroids by about 50 p. 100 in under 3 months without causing a flare-up of the disease. In a prospective series of 8 patients, Dapsone was given at the outset with Prednisone; the results were compared with a control series of 8 patients--the dose of steroids could be reduced earlier, the total duration of steroid therapy was shorter, and the total dose of steroids was lower. The main side effect of Dapsone is haemolysis which may give rise to anaemia, the severity of which is usually dose-dependent. A daily dosage of 75 to 100 mg would seem to provide a good compromise between the anti-inflammatory and haemolytic effects. Dapsone should always be given in association with steroids in the treatment of temporal arteritis; a closer biological surveillance of patients treated with association is necessary.

Aged↗