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Biomedical subjects

J M Burkart

Publications and source records attributed to J M Burkart.

At least 19 recordsLinked to original sources
PubMed2000

A multicenter study of noncompliance with continuous ambulatory peritoneal dialysis exchanges in US and Canadian patients.

Recent evidence suggested that noncompliance (NC) with continuous ambulatory peritoneal dialysis (CAPD) exchanges may be more common in US than in Canadian dialysis centers. This issue was investigated using a questionnaire-based method in 656 CAPD patients at 14 centers in the United States and Canada. NC was defined as missing more than one exchange per week or more than two exchanges per month. Patients were ensured of the confidentiality of their individual results. Mean patient age was 56 +/- 16 years, 52% were women, and 39% had diabetes. The overall admitted rate of NC was 13%, with a rate of 18% in the United States and 7% in Canada (P < 0.001). NC was more common in younger patients (P < 0.0001), those without diabetes (P < 0.001), and employed patients (P < 0.05). It was also more common in black and Hispanic than in Asian and white patients (P < 0.001). NC was more common in patients prescribed more than four exchanges daily (P < 0.0001) but was not affected by dwell volume. On multiple regression analysis, the independent predictors of NC, in order of importance, were being prescribed more than four exchanges per day, black race, being employed, younger age, and not having diabetes. Being treated in a US unit did not quite achieve significance as a multivariate independent predictor. These findings suggest that NC is not uncommon in CAPD patients and is more frequent in US than in Canadian patients. However, country of residence is less powerful as a predictor of NC than a variety of other demographic and prescription factors.

Adult↗
PubMed2000

Adequacy of peritoneal dialysis.

The National Kidney Foundation-Dialysis Outcomes Quality Initiatives guidelines have standardized many aspects of treating end-stage renal disease patients with peritoneal dialysis in an attempt to improve overall patient outcome. While recommending certain total solute clearance goals, the guidelines have also pointed out deficiencies in our knowledge base and precipitated many controversies. Some of these controversies have been resolved while others may have been interpreted wrongly, unnecessarily resulting in transfer of patients from peritoneal dialysis to hemodialysis due to "failure to meet adequacy targets" even when doing well clinically. This report reviews the rationale for the original guidelines and their subsequent modification. It also outlines a rational approach toward prescription modification based on peritoneal physiology. Specific solute clearance target goals discussed are the modifications for continuous ambulatory peritoneal dialysis (CAPD) and cycler peritoneal dialysis (CCPD), and a review of what solute clearance targets subsequent guidelines from other countries have used. Some examples are as follows: new guidelines suggest that solute clearance goals for creatine clearance should differ for low and low-average transporters than for high and high-average transporters (weekly clearance of 50 and 60 1/1.73 m(2), respectively) while Kt/V targets remain unchanged. Also discussed is the rationale for having the same target for patients on CCPD with a mid-day exchange as those for patients on CAPD. We are also reminded that solute clearance is only one aspect of "adequate" dialysis-blood pressure and volume control are equally important, and ways to maintain euvolemia and blood pressure control are discussed in the context of prescription management.

Creatinine↗
PubMed1999

An international study of patient compliance with hemodialysis.

CONTEXT: International differences in compliance of patients undergoing hemodialysis are poorly characterized and could contribute to international survival differences. OBJECTIVE: To compare international differences in patient compliance with hemodialysis treatments. DESIGN: A prospective observational study of patients undergoing hemodialysis in 1995 and a cross-sectional survey of health care professionals caring for hemodialyzed patients in 1996. SETTING AND PATIENTS: Four dialysis centers in the southeastern United States with 415 patients undergoing hemodialysis, 1 center in Sweden with 84 patients, and 4 centers in Japan with 194 patients participated in the prospective observational study. In the cross-sectional survey, nurses and nephrologists from the United States (n = 49), Japan (n = 21), and Sweden (n = 16) responded to questions regarding the compliance of their patients undergoing hemodialysis. MAIN OUTCOME MEASURES: Percentage of patients who miss a dialysis treatment and number of missed dialysis treatments. RESULTS: Of 415 US patients, 147 missed 699 treatments over a 6-month period (28.1 missed treatments per 100 patient-months or 2.3% of all prescribed treatments). During a 3-month period, there were 0 missed treatments per 100 patient-months for patients from Japan and 0 missed treatments per 100 patient-months for patients from Sweden (P<.001). In the cross-sectional survey, the mean (SD) estimated percentage of patients missing a treatment per month was 4% (3%) for the United States, 0% for Japan, and 0.1% (3%) for Sweden (P<.001). CONCLUSIONS: Noncompliance is much more common in US patients undergoing hemodialysis than Swedish and Japanese patients. The implications of these results for international differences in survival deserve further study.

Cross-Sectional Studies↗
PubMed1999

Dialysis modality and delayed graft function after cadaveric renal transplantation.

The purpose of this investigation was to compare outcomes in the immediate posttransplant period for hemodialysis (HD) and peritoneal (PD) dialysis patients who received cadaveric renal transplantation. Data were obtained from the United Network of Organ Sharing on all cadaveric graft recipients who were dialysis-dependent at the time of transplantation between April 1994 and December 1995. Baseline characteristics were compared between groups, and multivariate logistic regression was performed with outcome measures including urine production in the first 24 h posttransplantation (U24), requirement for dialysis in the first week posttransplant (FWDIAL), and treatment for acute rejection during the initial hospitalization. The odds of oliguria (not producing urine in the first 24 h) were 1.49 (1.28 to 1.74) times higher in HD versus PD patients. After adjustment for other comorbid conditions including age, gender, race, HLA mismatch, time on dialysis, panel-reactive antibodies, and cold and warm ischemia time, the odds of oliguria were 1.60 (1.14 to 2.25) times higher in black HD patients compared with PD patients and 1.29 (1.06 to 1.57) times higher in white HD patients. In a similar manner, after adjustment for significant comorbid conditions, the odds of requiring dialysis in the first week were 1.56 (1.22 to 2.0) times higher in black HD patients versus PD patients and 1.40 (1.21 to 1.60) times higher in white HD patients. The rate of acute rejection was similar during the first hospitalization. These results suggest that there is an association between hemodialysis and delayed graft function. Differences in biocompatibility between the two modalities could potentially be responsible.

Adult↗
PubMed1998

The Kidney Outcomes Prediction and Evaluation (KOPE) study: a prospective cohort investigation of patients undergoing hemodialysis. Study design and baseline characteristics.

PURPOSE: The purpose of the Kidney Outcomes Prediction and Evaluation (KOPE) study, was to more fully characterize the end-stage renal disease (ESRD) population with respect to social, psychological, and clinical characteristics, and to prospectively study the biomedical, social, and psychological factors that influence a range of ESRD outcomes in a large observational study of black and white patients on hemodialysis. This paper focuses on the KOPE study design as well as characteristics of patients at baseline. METHODS: KOPE was a prospective cohort investigation of patients treated at four dialysis centers in Forsyth County, North Carolina. Participants were interviewed at the dialysis centers, semi-annually over a 3 1/2 year period. Prevalent cases who were being treated with hemodialysis at the initiation of the study were enrolled into KOPE. Incident cases were subsequently enrolled as they presented to the participating units for hemodialysis. A total of 304 prevalent and 162 incident cases were enrolled into the study. The baseline health and sociodemographic characteristics of KOPE participants reported in this paper were obtained from medical records and Southeast Kidney Council data. Laboratory values taken within a 30-day interval around the baseline interview are also reported. RESULTS: KOPE participants differ from national statistics on race, age, and gender. Differences between KOPE participants and patients living in the region, but who did not participate in the study, can be explained by our recruitment criteria. CONCLUSIONS: KOPE will enable the characterization of the ESRD population, identification of factors related to poor outcomes, and identification of opportunities for interventions to prevent death and morbidity.

Adult↗
PubMed1998

Peritoneal dialysate fill-volumes and hernia development in a cohort of peritoneal dialysis patients.

A retrospective case control study was performed on a cohort of 244 peritoneal dialysis patients followed over 5 years to determine whether dialysate fill-volume was associated with hernia development. The laboratory and clinical parameters of patients who developed hernias during this time period were compared with those of patients who did not develop hernias. Information on 27 patients who developed hernias was compared with that on 217 patients who did not develop hernias. Dialysate fill-volume was similar between groups (2.2 +/- .3 L for patients with hernias vs. 2.2 +/- .3 L for controls). Three patients with fill-volumes of 1.5 L developed hernias, and no patients with fill-volumes of 3 L developed hernias. Age, duration of time on dialysis, and body surface area were also similar between groups. This investigation could not find a relationship between fill-volume and hernia formation. From this study it would appear that physicians should not hesitate to increase fill-volume based on concerns of hernia development.

Case-Control Studies↗
PubMed1998

Clinical experience: how much earlier should patients really start renal replacement therapy?

Data are needed to better determine the effect of initiation of dialysis on outcome. At present, it is unknown whether any of the previously reported improvements in survival "on" dialysis in patients who start "early" is solely due to lead time bias. Everyone involved with the care of ESRD patients must understand the concept of timely initiation, believe in it, and become fully educated about it. Incremental dialysis will require closer follow-up and proactive intervention. Protein restriction to prevent progression and timely initiation to prevent symptomatology are not mutually exclusive as noted by the MDRD experience. It is uncertain how much earlier the average ESRD patient would need to start dialysis. However, based on the MDRD experience, timely initiation of dialysis may likely only represent starting dialysis 4 to 5 mo sooner than the current approach to initiation in patients followed by nephrologists pre-ESRD. This "timely" initiation of dialysis would hopefully improve patient outcomes and in the long run be less costly. A multicentered, prospective, randomized trial is needed to better define the answers to these questions.

Humans↗
PubMed1997

Recommendations for clinical practice and research needs directed at reducing morbidity and mortality in peritoneal dialysis.

These presentations highlighted some of the current research needs in peritoneal dialysis. They are not meant to eclipse other important issues, such as adequacy and nutrition. These needs have become apparent as the therapy has evolved and progressed. They in fact are a testament to the increasing acceptance, use, and development of the therapy and suggest that there is potential for even further advancement for the therapy of peritoneal dialysis in the future.

Bacterial Infections↗
PubMed1996

Survival of patients undergoing renal replacement therapy in one center with special emphasis on racial differences.

This study compared racial differences in end-stage renal disease (ESRD) in 550 patients starting renal replacement therapy at a large academic dialysis center between January 1, 1990, and December 31, 1993, with follow-up through December 31, 1994. Patient groups were compared with respect to cause of ESRD, comorbid factors at the start of dialysis therapy, choice of modality, transplantation rate, and survival. Fifty-eight percent of the patients were white and 42% were African-American. There was a similar distribution of causes of ESRD between races. African-American patients were less likely to choose peritoneal dialysis as initial therapy (11.6% v 29.3%; P < 0.001) and were less likely to change dialysis modality. Transplantation rates were significantly different between African-American and white patients (9.3% v 27.6%; P < 0.001). African-Americans less frequently received living-related, living-nonrelated, and cadaveric renal transplants. Given differences in transplantation rates and in survival of transplanted patients versus patients on dialysis, survival analysis was performed without censoring for transplantation. A multivariate Cox proportional hazards model was formed, and the following were identified as being significant independent predictors of survival: age, race, age-race interaction, serum albumin at the start of dialysis, activity level at the start of dialysis, and presence of congestive heart failure and cancer. Age had little effect on survival among African-American patients, while it was a significant predictor of survival in white patients. In the group of patients starting dialysis before the age of 30 years, African-American patients had a significantly increased mortality risk compared with white patients. However, white patients older than 50 years had a higher mortality risk; this risk difference increased with age. Racial differences in mortality among older white patients could not be explained by differences in comorbid conditions, transplantation rates, or withdrawal from dialysis.

Black or African American↗
PubMed1996

Utilization of inpatient and outpatient resources for the management of hemodialysis access complications.

Complications of hemodialysis accesses are a major cause of morbidity in chronic hemodialysis patients. Although several investigators have reported on the utilization of inpatient services for hemodialysis access complications, there is a paucity of data regarding the utilization of outpatient services and temporary accesses for these complications. In this retrospective study, we identified all access-related inpatient admissions and outpatient encounters and procedures performed in an incident cohort of hemodialysis patients. Eighty-eight patients were followed for an average of 487.4 +/- 316.9 days, for a total of 119.1 patient-years of risk. The mean age was 57.0 +/- 14.6 years, with 55% females and 65% blacks; 31% of patients had diabetes mellitus as the primary cause of end-stage renal disease. Patients were referred to our nephrology practice a median of 56 days prior to the placement of a hemodialysis access and a median of 76 days prior to the initiation of hemodialysis. At the initiation of hemodialysis, 48 native arteriovenous fistulas and 40 polytetrafluoroethylene grafts were placed. Only 28 patients (31.8%) had a permanent access placed at least 14 days before the start of hemodialysis, resulting in the placement of 93 temporary accesses during the first week of dialysis therapy. Because of access complications, 21 patients had failure of their primary access, requiring the placement of 33 additional permanent accesses, including six native arteriovenous fistulas, 23 polytetrafluoroethylene grafts, and four permacaths, or an average of 0.28 new accesses per patient-year of risk. During the study period, 45 patients (51%) had at least one access complication. To manage these access complications, 25 fistulograms (0.21 per patient-year of risk) were performed and 116 additional temporary accesses (0.97 per patient-year of risk) were placed, including 50 femoral (43.1%), 52 subclavian (44.8%), and 14 internal jugular (12.1%) catheters. A total of 2.43 inpatient days and 1.05 outpatient encounters per year of patient risk were directly attributed to admissions solely for access complications. There is significant utilization of outpatient services, temporary accesses, and fistulograms in the management of hemodialysis access complications. These services should be included whenever a review of hemodialysis access procedures or costs are undertaken.

Adult↗
PubMed1996

Significance, epidemiology, and prevention of peritoneal dialysis catheter infections.

Catheter infections are a major cause of morbidity, catheter loss, and transfer to hemodialysis. These infections are mainly due to S. aureus. To date, treatment is less than optimal. Therefore, the primary goal should be prevention of catheter infections. Prevention is based on improving catheter design and implantation technique while using careful exit-site care. Prophylaxis with antimicrobials such as intranasal mupirocin or the use of silver-impregnated catheters appears promising as a way to reduce the risk of developing S. aureus infections. To optimize patient outcome, one must focus on these preventive measures.

Bacterial Infections↗