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Biomedical subjects

J M Cardamone

Publications and source records attributed to J M Cardamone.

13 recordsLinked to original sources
PubMed1982

Hepatic veno-occlusive disease caused by 6-thioguanine.

Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.

Adult↗
PubMed1980

Aplastic anemia associated with rubber cement used by a marathon runner.

Marathon runners are subject to many unique physical problems, especially blistering of the feet. Once the feet have become blistered, some runners use rubber cement, which contains benzene as an impurity, to keep adhesive tape in place over the denuded areas while running. We report the case of a marathon runner who used rubber cement in this fashion for more than one year in whom aplastic anemia developed.

Adhesives↗
PubMed1976

Ocular enucleation in a patient with severe classic hemophilia A.

A 27-year-old man with severe classic hemophilia A (antihemophilic globulin level: 1.5% of normal) had blunt trauma to his left eye that produced a corneoscleral laceration with prolapse of the intraocular contents. His left eye was enucleated under management with factor VIII replacement. This consisted of sufficient cryoprecipitate to increase the calculated circulating factor VIII level to 125%, sufficient factor VIII every 12 hours to increase peak postinfusion levels from 100 to 120%, and to maintain minimum levels of 30% immediately before infusion. Because he had developed a gingival hematoma when he was placed on epsilon amino caproic acid after only one day of factor VIII replacement following extraction of mandibular molars, we continued the high level of factor VIII replacement for five days and then began antifibrinolytic epsilon amino caproic acid therapy. His surgical and postoperative course were uneventful on this regimen.

Adult↗