Biomedical subjects

J M Carder

Publications and source records attributed to J M Carder.

4 recordsLinked to original sources

PubMed1986

Is Entamoeba histolytica in homosexual men a pathogen?

Entamoeba histolytica (EH) in homosexual men is generally considered to be pathogenic. To test this hypothesis, the generally accepted features of invasion (haematophagous trophozoites in faeces; high-titre serum antibody; moderate to severe acute inflammatory change; and presence of EH in the mucosa on rectal biopsy) and the zymodeme pattern of cultured trophozoites were assessed in twenty-three EH excretors and eleven control homosexual men. No trophozoites or antibody to EH were found in either group. When other pathogens were excluded, no patient in either group had severe, acute histopathological proctitis. Moderately severe change was seen in 38% of EH excretors and 18% of controls (not significant). All the zymodemes were non-pathogenic. Successful eradication of EH did not result in even a trend towards normalisation of the moderate inflammatory histopathology. There are, therefore, no data here to suggest that EH is a pathogen in homosexual men.

Adult↗

PubMed1985

Chlamydial proctitis?

Chlamydia trachomatis was isolated from 21 (7%) of 309 specimens obtained in October 1982 from the rectum of homosexual men undergoing proctoscopy. During the same period Neisseria gonorrhoeae was isolated from 12 (3%) of 454 specimens obtained similarly. The clinical features of patients infected with each of these micro-organisms were compared with those of an uninfected group of homosexual men. No characteristic diagnostic features were noted in the infected men.

Adult↗

PubMed1984

Spontaneous abortion--an infectious aetiology?

The role of Chlamydia trachomatis, genital mycoplasmas, Campylobacter spp. and other aerobic and anaerobic bacteria in the aetiology of spontaneous abortion was investigated prospectively in 241 pregnant women at a community hospital. Sixteen women who had threatened abortions were a little younger, of lower social class and had had more previous spontaneous abortions than the 76 women who aborted or the 149 women whose pregnancies were not complicated in the early stages by haemorrhage. The demographic characteristics of the latter two groups of women were similar. C. trachomatis was isolated from the cervix of only one woman and she had no genital-tract bleeding at any stage in her pregnancy. Mycoplasma hominis was isolated most often from the women who had threatened abortions but otherwise the prevalence of the other various micro-organisms was similar in women who had spontaneous abortions, threatened abortions, and in those who had pregnancies uncomplicated by vaginal bleeding. It was clear, therefore, that C. trachomatis played no role in the aetiology of spontaneous abortion in the population studied and there was no suggestion that any of the other micro-organisms were involved either.

Abortion, Spontaneous↗

PubMed1984

Is one swab enough to detect chlamydial infection of the cervix?

Three swabs were taken from the cervix of each of 104 women for the detection of Chlamydia trachomatis. The processing of three swabs instead of one increased the isolation rate by only 2%, and later swabs did not result in the production of more chlamydial inclusions than first swabs. In most clinics, therefore, a single cervical swab is adequate to detect chlamydial infection.

Chlamydia Infections↗