Biomedical subjects

J M Cilluffo

Publications and source records attributed to J M Cilluffo.

7 recordsLinked to original sources

PubMed1984

Intracranial schwannoma of the hypoglossal nerve.

Two patients had a solitary intracranial schwannoma of the hypoglossal nerve. Such schwannomas are rare, and these two cases bring the total number of reported cases to 16. Hemiatrophy of the tongue is always present but is rarely reported by patients. Diagnosis can be facilitated by high-resolution computed tomographic scanning of the posterior fossa and foramen magnum region. The hazards formerly associated with removal of these tumors have largely been eliminated.

Adult↗

PubMed1983

The diagnosis and surgical treatment of intracranial arachnoid cysts.

Intracranial arachnoid cysts are becoming a more frequent finding as a result of the increased use of cranial computed tomography. We present 26 patients with such lesions treated surgically at the Mayo Clinic between 1970 and 1980. In children the commonest presenting symptom was cranial enlargement, whereas in adults headaches were most common. On examination, most patients were normal, although focal deficits related to the site of the lesion were not rare. Computed tomography scanning was the definitive study in essentially all the patients. Direct surgical excision was the preferred therapy in most patients. Complications included three subdural hygromas in children, one wound infection, one death from anterior spinal artery thrombosis, and one case of seizures post-operatively.

Adolescent↗

PubMed1982

Idiopathic thoracic intradural and extradural arachnoid diverticula. Report of a case.

Intraspinal arachnoid diverticula are unusual lesions that may demonstrate significant mass effects. A 15-year-old boy with upper lumbar discomfort and progressive spastic paraparesis also demonstrated a sensory deficit at T-10 as well as a severe lower extremity dorsal column deficit. Radiographic evaluation demonstrated interpedicular widening from T-2 to T-9. Myelography revealed a triloculated arachnoid diverticulum, with major collections at C-7 to T-2, T-3 to T-5, and T-8 to T-10. An eight-level laminotomy (T-2 to T-9) was performed, leaving the spinous processes and interspinous ligaments intact. The inferior collection was completely extradural, with a diverticular neck leaving the right nerve root sleeve at T-8. The other loculations were intradural. The lesion was excised without difficulty, and the laminae were replaced. The postoperative course was unremarkable, in that recovery occurred almost immediately, and the patient's strength was essentially normal on discharge. In treating such lesions, replacement laminotomy is the best approach.

Adolescent↗

PubMed1982

Cerebral blood flow, brain pH, and oxidative metabolism in the cat during severe insulin-induced hypoglycemia.

The effects of severe hypoglycemia on brain pH, cerebral blood flow (CBF), and other physiologic and metabolic parameters were studied in 26 cats subjected to insulin hypoglycemia. Two groups were utilized to compare the effects of anesthesia. The halothane group was composed of 14 animals and the barbiturate group contained 12 animals. Insulin was administered by both the intravenous and intramuscular routes until there was a severe electroencephalographic (EEG) change or until 6 h had elapsed. The cerebral responses to hypoglycemia demonstrated the following: CBF was unaffected by severe hypoglycemia in normotensive animals with or without EEG changes; brain pH was essentially constant in all groups regardless of glucose levels, CBF, or EEG; and the EEG abnormalities corresponded closely to brain glucose levels. Cerebral adenosine triphosphate and phosphocreatine levels were lowest in the animals with isoelectric EEGs. We conclude that CBF and brain pH in the normotensive cat under general anesthesia are relatively unaffected by insulin hypoglycemia despite the presence of severe EEG changes and diminished cerebral energy reserves. The study suggests tha the PaCO2-CBF response curve is ot dependent upon the metabolic integrity of cerebral tissue and is mediated by pathways separate from those of autoregulation.

Animals↗

PubMed1981

Intracranial ceruminous gland adenocarcinoma.

Patients with adenocarcinoma of the ceruminous gland arising in the middle ear have a typical syndrome consisting of unilateral hearing loss, otalgia, facial paresis, and a middle-ear mass. Adjacent cranial nerves also may be affected. Some patients may have an ipsilateral cerebellar ataxia if the lesion extends into the cerebellopontine angle and compresses the cerebellar hemisphere. Obstructive hydrocephalus may occur secondary to obstruction of the aqueduct or fourth ventricle. The initial clinical findings may be those of a jugular foramen syndrome. These lesions are usually slow-growing and may be associated with a very prolonged clinical course. Although the tumors are rare, the physician should be aware of their existence if proper care is to be given.

Adenocarcinoma↗

PubMed1981

Idiopathic ("congenital") spinal arachnoid diverticula. Clinical diagnosis and surgical results.

We reviewed the clinical records of all the patients examined at the Mayo Clinic who were operated on and found to have arachnoid diverticula of he cervical and thoracolumbar regions of the spinal column. Only patients whose lesion did not have a traumatic cause were selected for a study. There were 21 patients: 20 had been operated on at the Mayo Clinic and 1 was seen 43 years after surgery done elsewhere. The symptoms associated with the thoracolumbar lesions were, in order of decreasing frequency, pain, weakness, gait disorder, sensory symptoms, and sphincter dysfunction. The conditions associated with thoracic arachnoid diverticula included congenital pigmented nevus, diastematomyelia, multiple sclerosis, Marfan's syndrome, and syringomyelia.

Adolescent↗

PubMed1980

Posttraumatic arachnoidal diverticula.

Arachnoidal diverticula of the spinal cord and nerve roots are relatively common lesions. Many of these lesions are congenital, but some may occur as a result of trauma or spinal surgery. This report reviews the Mayo Clinic experience with postsurgical and traumatic lesions. Of the 17 patients in the series, 11 had previous operation in the region of the lesion and 6 had nonsurgical trauma.

Adult↗