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J M Debonne

Publications and source records attributed to J M Debonne.

At least 37 records · Page 2Linked to original sources
PubMed1998

[Eosinophilic gastroenteritis: an example of gastrointestinal toxicity of eosinophils].

Toxicity of polynuclear eosinophils in the digestive tract results from a cascade of immune responses involving various mediators including mastocytes and T-lymphocyte helpers. Polynuclear eosinophils may be implicated in many digestive disorders. This involvement is well established in eosinophilic gastroenteritis which has become the model for study of eosinophil toxicity on the digestive tract. Considered to be of uncertain etiology up until 1998, this mechanism is well illustrated by the case described in this report involving infiltration of all layers of the small intestinal mucosa in a 23-year-old patients who responded well to corticosteroid treatment. This case provides the opportunity to update physiopathologic and therapeutic data concerning this unpredictable syndrome. Current evidence of transition forms from idiopathic hypereosinophilic syndrome casts doubt on the conventional classification of eosinophilic gastroenteritis and underlines the need for careful diagnostic work-up and prolonged follow-up.

Abdominal Pain↗
PubMed1997

[Helicobacter pylori infection in developing countries].

Helicobacter pylori infection is probably the most common bacterial infection in the world. The pathogenicity of this bacteria has been recognized since 1989 in the developed world where prevalence is 20 to 40%. Its role in gastric and duodenal disease is certain and its low recurrence rate justifies eradication. In the developing world prevalence of Helicobacter pylori infection is over 80% with contamination being maximal in children. Transmission is oro-oral and even feco-oral. Crowded living conditions is the determinant factor. Helicobacter pylori infection exhibits special features in developing world. The prevalence of gastroduodenal disease varies according to geographic area independently of the prevalence of Helicobacter pylori infection and stomach cancer is uncommon. In newborns Helicobacter pylori infection seems to be the primary event for chronic malnutrition and diarrhea syndrome with failure to thrive. In practice detection of Helicobacter pylori is difficult in the developing world and presumptive treatment is always followed by recurrence. In the future active or passive immunization will be the solution.

Adolescent↗
PubMed1994

Characteristics of serogroup A Neisseria meningitidis strains isolated in the Central African Republic in February 1992.

A severe epidemic of serogroup A meningococcus meningitis occurred in the northwest Central African Republic from January to March 1992. Strains from 24 patients were characterized using serotyping, testing of susceptibility to antibiotics, and multilocus enzyme electrophoresis. In 23 of the 24 patients the causal strain was found to be 4:P1.9/clone III-1. These results indicate that such strains continue to spread in Africa and have taken hold in areas outside the "meningitis belt." This may be a consequence of changing climatic conditions.

Adolescent↗
PubMed1994

[Spontaneous intramural hematoma of the esophagus. Apropos of a case].

The authors report a case of spontaneous intramural haematoma of the oesophagus. This is a rare observation which usually occurs in association with oesophageal hyperpressure and sometimes with impaired haemostasis. The strategy for diagnosis is based on tomodensitography and also endosonography and magnetic resonance imagery.

Aged↗
PubMed1993

[Common variable hypogammaglobulinemia. A rare cause of chronic diarrhea. A case].

In patients with chronic diarrhoea investigations exceptionally reveal a common variable hypogammaglobulinaemia. A 42-year old man presenting with chronic bronchitis and asymptomatic post-hepatitis B cirrhosis was hospitalized for evaluation of a chronic diarrhoea accompanied by altered general condition. Investigations detected global hypogammaglobulinaemia, diffuse lymphoid hyperplasia of the small bowel, and lambliasis. Treatment with gammaglobulins and antibiotics resulted in disappearance of symptoms. This was a rare disease due to a primary disorder where global hypogammaglobulinaemia was associated with a normal number of circulating B-cells. Prognosis was cautious in view of the risk of malignant proliferation.

Adult↗
PubMed1993

[Sicca syndrome and low-grade chronic viral hepatitis C. Apropos of a series of 50 cases].

Systemic manifestations are described in chronic hepatitis C. Haddad et al have showed the prevalence of sicca syndrome with lymphocytic sialadenitis. We analysed prevalence in 50 patients suffering from chronic hepatitis C with histologic low rank. 50% of them have pronounced abnormality of lachrymal secretion without sialadenitis. It seems that sicca syndrome is present in low rank hepatitis. In that case xerophtalmia preceded xerostomia.

Hepatitis C↗