Episodic hysterical stuttering.
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Biomedical subjects
Publications and source records attributed to J M Doro.
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A 55-year-old man became acutely psychotic and had a pseudoseizure after receiving six doses of intravenously administered trimethoprim-sulfamethoxazole. These symptoms resolved within 24 hours after discontinuation of the medication; this finding suggests a causal effect of the drug administration.
Patients with seizures accompanied by generalized cortical electrodecremental event (CEE) have clusters of clinical spells with tonic, dystonic, or atonic components and involvement of autonomic functions. When electroencephalographically detectable foci are present, they behave in a peculiar way; throughout the entire cluster of seizures focal spiking is reduced in the short interictal periods as well as during each individual seizure with CEE, at which time it is suppressed. Focal firing reappears reinforced at the end of each spell and also at the end of the cluster. These facts suggest that the foci responsible for CEE are deeply located. A complex excitatory-inhibitory feedback probably exists between cortical and subcortical foci. These seizures should be differentiated from similar attacks of nonepileptic or epileptic nature. A correct diagnosis is essential given the different therapeutic implications.
Thirty-two EEGs from six cases of Aicardi's syndrome were reviewed. A characteristic EEG pattern was found in all cases. This consists of multifocal epileptiform abnormalities occurring on a burst-suppression pattern showing complete asynchrony between the two hemispheres. This pattern has been described so far only in Aicardi's syndrome. These characteristic EEG features are more readily found early in the course of the disease and occur less frequently six months after from the onset of symptoms, at which time they are often replaced by multiple epileptic foci on a severely disorganized background. The EEG sleep pattern was profoundly altered in all stages of the disease. The EEG is considered a helpful tool in the diagnosis of Aicardi's syndrome.
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