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Biomedical subjects

J M Foley

Publications and source records attributed to J M Foley.

34 records · Page 2Linked to original sources

Baclofen for spasticity in multiple sclerosis. Double-blind crossover and three-year study.

Baclofen is a safe and effective means for treating spasticity associated with multiple sclerosis. We found no toxic effects on hepatologic, hematopoietic, or renal function, acutely or for over 3 years of follow-up. A statistically significant reduction was noted in frequency of spasms, and clonus, and there was improved range of joint movement, which enabled patients to maintain functional status for prolonged periods. For the more disabled patients, treatment with baclofen gave symptomatic relief of painful spasms and made immobility more tolerable. Optimum effect was achieved when baclofen was administered in the early stages of disease, before major disabilities became permanent.

Activities of Daily Living

Further factor-analytic investigation of the Thorne femininity study.

The responses of 512 undergraduate women to 198 items of the Thorne Femininity Study were factor analyzed in order to isolate the dimensions of femininity represented among the items of this instrument. The procedure used isolated 11 orthogonal factors that accounted for 21.1% of the total variance. Three additional samples of women were tested (total N=222) and compared to the college age samples on the 11 factors. The various samples differed in many systematic and statistically significant ways. Suggestions were made as to the possibility of developing new items to measure some aspects of femininity not represented completely among the items analyzed.

Adolescent

Necrotizing sialometaplasia of the mandible.

A brief review of the literature on necrotizing sialometaplasia has been presented. A patient with necrotizing sialometaplasia of the retromolar pad is reported. This is the first such lesion to be described in an oral site other than the palate. Clinical, histologic, and etiologic aspects of the lesion have veen discussed.

Adult

Effect of distance information and range on two indices of visually perceived distance.

Subjects made verbal reports of the perceived distance of near visual targets and indicated their distances by pointing at them with an unseen hand. The targets were presented under three stimulus conditions: monocular, binocular, and multicue. Two ranges of target distance were studied in separate experiments: 11-39 cm and 21-33 cm. When reciprocals of both response distance and target distance were plotted, all functions were approximately linear. The verbal and manual responses (distance indices) differed greatly, but were found to be related by a constant transform. The range of target distances had no effect on either index. The standard deviation of the manual response was about half that of the verbal response. Stimulus condition had a large effect, with the multicue condition producing the greatest change in indicated distance. and the monocular condition the least. The results are discussed with reference to the definition of perceived distance, and hypothesis concerning the integration of distance information.

Adult