[Value of external transcystic biliary drainage in severe liver injuries].
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Bile↗
Biomedical subjects
J M Frapier
Publications and source records attributed to J M Frapier.
[Total colonic form of Hirschsprung disease. Apropos of 6 cases].
6 patients with total colonic aganglionosis without small bowel involvement (HCT) have been observed during a 13-years period. From this material and a review of literature, the authors stress the diagnostic and therapeutic particularities of HCT, which justify a separate analysis and a comparative study with the more typical forms of Hirschsprung's diseases. The percent of HCT out of all types of Hirschsprung's disease is 7.9%. Male to female ratio is 2:1 and familial occurrence is much higher (15 to 20%) than that seen in the classical form of Hirschsprung's diseases. A diagnosis of HCT is more difficult because of lack of specificity in clinical picture, radiologic findings and manometric evaluation. However, age at time of revelation is the neonatal period in 83% and enterocolitis is present in 25% with a higher incidence than in shorter types of Hirschsprung's disease. Therefore in HCT, laparotomy with appendicectomy and open frozen biopsies is always required for correct diagnosis. Ileostomy is mandatory. It must be done early and adequate in situation and technic. This kind of diversion has its own morbidity and mortality with a higher rate than that observed after colostomy. Definitive operation must be ideally performed at age 2. The principal of preserving and utilizing a segment of colon in a side-to-side anastomosis to the ganglionated small-bowel, followed by a pull-through ileoproctostomy has been established as a reasonable treatment for HCT since Martin's first description. 5 cases underwent a Martin repair and 1 a total colectomy.(ABSTRACT TRUNCATED AT 250 WORDS)
Cecum↗
[A rare etiology of rectal bleeding: Meckel's leiomyoblastoma. Value of celiomesenteric arteriography].
A rare case of leiomyoblastoma developing in Meckel's diverticulum and revealed by massive rectorrhagia is reported. The characteristic clinicopathologic features of these tumors in their small intestine localization are described and the value of celiomesenteric arteriography emphasized for their topographic and even nosologic diagnosis.
Celiac Artery↗
High prevalence of small dense LDL as an underestimated component of heart transplantation-induced dyslipidemia: potential role in graft coronary vasculopathy?
Heart transplantation-induced dyslipidemia is a recognized risk factor for cardiac allograft vasculopathy that affects survival prognosis. Beyond increased lipids, low-density lipoprotein (LDL) size and systemic factors, including glucose intolerance, oxidative stress, and inflammation, must be taken into account as components of the atherosclerotic risk. The aim of this study was to explore the atherogenic profile of heart transplant recipients (HTR) by assessing lipid parameters, glycemia, oxidative stress status, and inflammation in 59 transplant patients (follow-up of 6 +/- 3 years) compared to 20 healthy volunteers. Classical hypercholesterolemia and hypertriglyceridemia were observed in HTR compared to controls, associated with increased apoCIII levels (0.13 +/- 0.6 vs 0.07 +/- 0.03 g/L, P < .01). Mean LDL size was reduced in HTR compared to controls (25.22 +/- 0.72 vs 26.06 +/- 0.54 nm, P < .001) with an abnormally high prevalence (69% vs 0%, P < .001) of small dense LDL (<25.5 nm). Hyperglycemia (7.3 +/- 3 vs 5.4 +/- 0.8 mmol/L, P < .05) and inflammation (high-sensitive CRP: 3.1 +/- 3 vs 1.6 +/- 0.9 mg/L, P < .001) were evidenced in HTR since no difference in oxidative stress parameters was observed. In conclusion, a high prevalence of small dense LDL is an important component of posttransplantation dyslipidemia.
Biomarkers↗
[Surgical treatment of gastroesophageal reflux in children. Apropos of 77 cases].
Seventy-seven children with gastro-esophageal reflux have been operated upon during the last 21 years. Gradually added to the classical digestive symptoms and signs were those of respiratory disorders varying between asthma and the "missed sudden death" syndrome. Analysis of anatomical forms showed a predominance of cardio-antral malpositionings (58%) in this age group (mainly young babies). Surgical treatment, presently based on that of Toupet, apart from classical formal indications, is conducted after 3 to 4 months of medicopostural therapy when there is persistence of reflux and/or of esophagitis on fibroscopy in cardio-antral malpositions. Particularly as results of this surgery are good (disappearance of reflux in 83% of cases).
Adolescent↗