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Biomedical subjects

J M Gaio

Publications and source records attributed to J M Gaio.

27 records · Page 2Linked to original sources
PubMed1985

Effects of tiapride in tardive dyskinesia.

Tiapride, a selective D2 dopaminergic receptor blocking agent from the substituted benzamide class, was evaluated in a blind video-controlled trial in 10 psychiatric patients with tardive dyskinesia. There was a significant decrease in dyskinesia with a parallel increase in parkinsonism. This relationship between two opposite effects on movement suggests a common pathophysiological basis lying on a reciprocal hyper- and hypoactivity of the dopaminergic striatal system. Nevertheless, other mechanisms may be involved, for the evolution of individual parkinsonian and dyskinesia scores is not necessarily opposite: the tiapride-induced parkinsonism was generally acceptable and in two cases, the dyskinesia scores were reduced without an increase in parkinsonism. Therefore, more dyskinetic patients have to be evaluated in long-term studies with tiapride, before this drug could be recommended in tardive dyskinesia, when dyskinetic movements become intolerable.

Adult↗
PubMed1985

[Isolated ipsilateral lateropulsion caused by bulbar hematoma].

A case of hematoma involving probably the reticular formation of the medulla oblongata is reported. Examination showed a soft palate paresis and an ipsilateral axial lateropulsion without vertigo or oculomotor disorders. The mechanism of the lateropulsion is discussed. During the spontaneous recovery a transient hydrocephalus was observed.

Aged↗
PubMed1985

[Left anterior choroidal artery syndrome with language disorders and constructional apraxia].

The infarction in the territory of the anterior choroidal artery may induce a sensory motor impairment and neuropsychological symptoms close to those observed in some thalamic lesions. In a right handed man with a left sided infarction, language disturbances and constructional apraxia were observed. Cerebral blood flow measurements were performed 4 days after the stroke with the 133Xenon inhalation method. A decrease of mean hemispheric values was observed on both sides but more so on the left hemisphere, in the left frontoparietal regions. 98 days after the stroke language and constructional apraxia have partially improved. We have drawn a parallel between blood flow variations and neuropsychological signs. The cortical deafferentation caused by the interruption of the thalamo-cortical projections may explain the focalized decrease in cerebral blood flow values in the left hemisphere.

Adult↗
PubMed1984

[Paralysis of the hypoglossal nerve caused by 2 aneurysms and a dissecting aneurysm of the internal carotid artery].

Palsies of the lower cranial nerves caused by a compressive pathological carotid artery are not common. Three cases of paralysis of the hypoglossal nerve, hypoglossal and vagus, hypoglossal, glossopharyngeal and vagus nerves, are reported. In 2 patients the symptoms were related to an extracranial carotid artery aneurysm below the base of the skull and in 1 patient to a spontaneous carotid dissecting aneurysm. It is possible that some localized arterial dissecting aneurysms evolve to a localized aneurysmal sac, especially if they are located between Cl and the base of the skull. The tongue paralysis disappeared in 2 patients.

Adult↗
PubMed1982

[Bromazepam in anxiety. Clinical evaluation (author's transl)].

In an open study, 30 patients with anxiety were treated with bromazepam 6 to 9 mg/day and followed-up for 15 days either as out-patients or in hospital. The results, assessed by anxiety scores, showed a 71,4% improvement, which was often perceptible as early as the third day of treatment. The best responses were obtained in patients who had not previously received anxiolytic drugs and in those who had less anxiety at the beginning of treatment. In two cases the drug was discontinued on account of daytime drowsiness.

Adolescent↗
PubMed1982

[Modification of extrapyramidal signs by apomorphine associated with various dopaminergic antagonists].

An acute administration of various doses of apomorphine, a dopaminergic agonist, and of dopaminergic receptor blockers (domperidone, sulpiride, haloperidol), was double-blindly achieved in a parkinsonian patient also suffering from dyskinesia. Apomorphine improved tremor and dyskinesia proportionnally to the dose. Domperidone did not prevent from this beneficial effect whereas sulpiride or haloperidol revealed a competitive antagonism versus apomorphine.

Aged↗