Placental site trophoblastic tumor metastasizing to the brain. Case illustration.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
J M Gilsbach
Publications and source records attributed to J M Gilsbach.
Health-related quality of life after aneurysmal subarachnoid hemorrhage: impacts of bleeding severity, computerized tomography findings, surgery, vasospasm, and neurological grade.
OBJECT: Based on the results of earlier studies it is agreed that the significance of aneurysm location and surgery for neuropsychological impairments after subarachnoid hemorrhage (SAH) is secondary to the effects of the bleeding itself. Therefore, the present study was performed to evaluate whether bleeding, acute clinical course, and surgery have persistent effects on health-related quality of life (QOL) after SAH. METHODS: A series of 116 patients was examined for 4 to 5 years (mean 52.2 months) after aneurysmal SAH by means of a QOL questionnaire. Eighty-six patients (74.1%) had undergone surgery early (< or = 72 hours post-SAH). There were 77 women (66.4%) and 39 men (33.6%) in the study group, and the mean age of the patients was 50.3+/-13.3 years (range 30-69 years). Patients who had undergone surgery for a left-sided middle cerebral artery (MCA) aneurysm complained of significantly more impairments in social contact, communication, and cognition than those treated for a right-sided MCA aneurysm. No other effects of aneurysm location (including the anterior communicating artery) emerged. Multiple aneurysms, intraoperative aneurysm rupture, and partial resection of the gyrus rectus had no adverse effects on later daily life. Only temporary clipping was associated with increased complaints in some QOL areas. Disturbances of the circulation of cerebrospinal fluid and the presence of intraventricular hemorrhage led to more impairments in daily life. Specific effects of the anatomical pattern of the bleeding could be identified, but no adverse effects of vasospasm were found. Multivariate analyses revealed, in particular, that patient age and admission neurological status (Hunt and Hess grade) are substantial predictors of the psychosocial sequelae of SAH. CONCLUSIONS: In contrast to the mild effects of aneurysm surgery, patient's age, initial neurological state on admission, and the bleeding pattern substantially influence late QOL after SAH.
Adult↗
Functional and diffusion-weighted magnetic resonance images of space-occupying lesions affecting the motor system: imaging the motor cortex and pyramidal tracts.
OBJECT: During neurosurgical interventions, preservation of subcortical axons is as important as preservation of cortical neurons. The goal of this study was to assess the combined use of functional (f) and diffusion-weighted (DW) magnetic resonance (MR) imaging to assist in the preservation of the structure and function of the motor system. METHODS: The authors evaluated the combination of fMR imaging and DW MR imaging to detect cortical motor areas with their corresponding pyramidal tracts in 12 healthy volunteers and in 10 consecutive patients with various space-occupying lesions affecting the central motor system. Activation within the primary motor cortex (M1) and white matter bundles originating from this cortical region was demonstrated in 21 of the 22 individuals examined. Additional activation was exhibited along the course of white matter tracts at the level of the pons and. in the contralateral hemisphere, in the M1. Fiber tract displacement was visualized in all patients in white matter that had appeared normal on routine T1- and T2-weighted MR images. CONCLUSIONS: The combination of DW MR and fMR imaging allows visualization of the origin, direction, and functionality of large white matter tracts. This will prove helpful for imaging structural connectivity within the brain during functional imaging. Moreover, local relationships of cerebral tumors that encroach upon M1 and subcortical fiber tracts can be defined. This promises to decrease patient morbidity and to broaden the clinical applications of functional imaging.
Adult↗
Hemodynamic changes in simple partial epilepsy: a functional MRI study.
We performed functional MRI (fMRI) on a patient with a mass lesion while she happened to experience a simple partial seizure. We used regional T2* signal changes to localize seizure-related hemodynamic changes. Seizure activity was associated with changes in MR signal in different regions that showed sequential activation and deactivation. Our study has shown that epileptic activity leads to changes in cerebral hemodynamics. In selected patients, therefore, it might be possible to use fMRI as a noninvasive tool to detect and investigate cortical patterns of activation associated with seizure activity.
Brain Neoplasms↗
Is the head position during preoperative image data acquisition essential for the accuracy of navigated brain tumor surgery?
OBJECTIVE: To analyze the influence of head positioning during preoperative image data acquisition on intraoperative accuracy of modern neuronavigation systems. MATERIAL AND METHODS: All measurements were performed preoperatively before opening the head. In 24 patients, preoperative MR image data acquisition was performed twice on a 0.5 T scanner using a contrast-enhanced T1-weighted sequence; first in the neutral head position, and thereafter in the surgical head position for pterional craniotomy. For both data sets, the Sylvian fissure, the central sulcus, and the superior and inferior temporal sulci were depicted on the patient's scalp using the frameless neuronavigation system EasyGuide Neurotrade mark. At the beginning of surgery, with the head fixed in a Mayfield clamp and an articulated instrument holder being used for fixation of the navigation system's pointer, the distances of 10 correlating points of the sulci for the two data sets were measured. To evaluate the accuracy of the navigation system in this experimental set-up, a phantom study was also performed. RESULTS: The phantom study revealed a mean inaccuracy of 1.6 mm (range 0.1-2.3 mm, standard deviation 0.6 mm). The patient study revealed a mean inaccuracy of 1.8 mm (range 0.4-2.8 mm, standard deviation 0.5 mm). CONCLUSIONS: The data suggest that the positioning of the patient's head during preoperative imaging plays no relevant role in intraoperative accuracy of neuronavigation. However, further studies and a larger number of patients with various pathologies in different regions of the brain are necessary to obtain a better understanding of the problem of brain shift in neuronavigation due to patient positioning alone, and to avoid procedure-related operative morbidity.
Adult↗
Morphological changes following experimental intraventricular haemorrhage and intraventricular fibrinolytic treatment with recombinant tissue plasminogen activator.
Intraventricular haemorrhage (IVH) occurs in up to 50% of patients with primary intracerebral haemorrhage and aneurysmal subarachnoid haemorrhage. It is a significant and independent contributor to mortality and morbidity in these intracranial haemorrhages. Using a model of isolated IVH, we assessed the morphological changes induced by intraventricular bleeding and investigated the effects of intraventricular fibrinolytic treatment following IVH. IVH was induced in 32 pigs by intraventricular infusion of 10 ml autologous blood along with thrombin. The treatment group received an intraventricular injection of 1.5 mg (1 mg/ml) tissue plasminogen activator (tPA) following the injection of blood. The placebo group received the same volume of normal saline. Morphological examinations of the brains were carried out 7 days and 6 weeks following IVH. The ventricles were incompletely filled with blood and significantly enlarged in the placebo group 7 days after the IVH. In contrast, no residual intraventricular clots were visible in the animals treated with tPA, and the diameters of the lateral ventricles had returned to normal within 7 days. Marked losses of the ependymal covering of the ventricular walls were found in the placebo-treated animals, while the ependymal layer was largely intact in the animals treated with tPA. No haemorrhages induced by tPA were observed. The results indicate that intraventricularly administered tPA significantly enhances the lysis of intraventricular blood clots, accelerates the resolution of acute posthaemorrhagic hydrocephalus, and preserves the integrity of the ependymal layer.
Animals↗
Subarachnoid haemorrhage as initial symptom of multiple brain abscesses.
The case of evolving multiple brain abscesses which became symptomatic with a sudden hemianopsia and the clinical and radiological signs of a subarachnoid haemorrhage, is reported. A common pathomechanism which could explain both the sudden focal neurological deficit and the subarachnoid bleeding is discussed.
Brain Abscess↗
Virtual pointer projection of the central sulcus to the outside of the skull using frameless neuronavigation -- accuracy and applications.
BACKGROUND: The purpose of this prospective study was to localize the central sulcus by frameless neuronavigation and to project this anatomical structure to the outside of the skull on the skin. This method was analyzed in respect to its practicability, accuracy, and potential applications. METHOD: In 27 patients investigated (28 unaffected hemispheres), the central sulcus was virtually projected to the outside of the skull using frameless neuronavigation and a virtual pointer elongation of 15 or 20 mm. The following parameters were measured on the scalp: 1. the distance between the bregma and the midline junction of the central sulcus, and 2. the angle between the central sulcus and the midline. These dada were compared with measurements based on the original axial MR images of these patients. Finally, a laboratory phantom study was designed in analogy to a patient's examination for estimation of the overall accuracy of the neuronavigation system in the experimental setup used in this study. FINDINGS: Virtual pointer projection of the central sulcus to the outside of the skull using frameless neuronavigation was found to be easily possible. The distance between the bregma and the midline junction of the central sulcus amounted to a mean of 55 mm on the left and 56 mm on the right. The angle between the central sulcus and the midline reached a mean of 63 degrees on the left and 60 degrees on the right. These data confirmed results of other studies with no frameless neuronavigation devices. The phantom study revealed a mean overall inaccuracy of 0.9 mm at a virtual pointer elongation of 15 mm. At a virtual pointer elongation of 20 mm, the mean overall inaccuracy of our study was 1.1 mm. These results correspond to the inaccuracy of frame based stereotaxy. INTERPRETATION: It is easily possible, valid, and reliable to virtually project the central sulcus to the outside of the skull with an acceptably low inaccuracy using frameless neuronavigation. This is important for research studies that correlate and integrate different functional imaging methods with the aid of frameless neuronavigation.
Adult↗
Microsurgical treatment of spontaneous and non-spontaneous spinal epidural haematomas: neurological outcome in relation to aetiology.
BACKGROUND: This retrospective study evaluated the neurological outcome of 26 patients with spontaneous and non-spontaneous spinal epidural haematoma (SEH) who underwent microsurgical clot removal. It was the objective of the present study to investigate whether the aetiology of the SEH has an influence on the neurological outcome. METHODS: The medical records and radiological investigations of 26 patients with SEH were re-examined, and the latency between symptom onset and operation, and the size of the haematoma were determined. Motor and sensory function had been evaluated before surgery and 90 days after discharge. FINDINGS: Fourteen patients with non-spontaneous SEH and 12 patients with spontaneous SEH were identified. After surgery, neurological deficits improved in 9 of the patients with spontaneous (75%) and in 13 of the patients with non-spontaneous SEH (93%). In cases of spontaneous SEH, the median latency between symptom onset and operation was longer (72 hrs vs 7 hrs) and the median extent of the haematoma was larger (3.5 vs 2 spinal segments), than in the non-spontaneous cases. INTERPRETATION: Neurological outcome seems to be related to the aetiology of the SEH. Better outcome was observed in patients with surgically treated non-spontaneous SEH. Two explanations for this finding are worth considering. First, patients with non-spontaneous SEH usually are already under medical surveillance and can undergo medullary decompression more rapidly. Second, the compression of the spinal cord is possibly less severe in non-spontaneous SEH because of their smaller size.
Adolescent↗
Removal of adherent ventricular catheters by a modified sheath introducer system: technical note.
BACKGROUND/PURPOSE: A series of technical notes has been dedicated to the removal of retained intracranial shunt catheters, among which the intraluminal cautery proved to be the most accepted technique. However, several reports showed that these techniques still harbor potentially serious complications. METHODS: In this technique, a modified plastic sheath introducer system is passed over the retained ventricular catheter. While advancing the tube along the longitudinal axis of the catheter, circular movements of the tube around the longitudinal axis of the catheter are performed, allowing the tube to act as a spherical knife cutting the ingrown choroid plexus or ependymal adhesions. RESULTS: There were no procedure-related complications in any of the 9 patients treated by the technique described. The procedure proved to be easy and effective in all cases. In addition, in case a new ventricular catheter was needed at the same site, it could be placed via the same tube. CONCLUSIONS: The technique described seems to be an easy, safe, and effective alternative to other techniques for removal of retained ventricular catheters. However, considering the limited number of patients treated with the technique described and the great number of patients treated by the widely accepted intraluminal cautery, one cannot claim the one technique as superior to the other at this stage.
Cardiac Catheterization↗
Subdural-atrial and subdural-peritoneal shunting in infants with chronic subdural fluid collections.
BACKGROUND: In symptomatic infants with chronic subdural fluid collections a variety of treatment strategies, such as observation, repeated subdural tapping, external or internal subdural drainage, and craniotomy have been advocated. Until now, the ideal management for this etiologically heterogenous group of children seems controversial. METHODS: The authors present their treatment with subdural-peritoneal and subdural-atrial shunts and the follow-up in 8 infants (mean age, 7 months) with bifrontal subdural hygromas and hematomas caused by different etiologic conditions. RESULTS: Initially, all children were symptomatic, and repeated subdural taps showed no clinical and neuroradiologic benefit. Shunting resulted in disappearance of all clinical signs in all infants, with complete removal of the chronic subdural fluid collections in 6 cases and remarkable improvement in 2 cases. In all infants the shunt system was removed after disappearance of signs and decrease of fluid collections. As the only complication the shunt system had to be removed in 1 case on the fourth postoperative day because of infection without any further disadvantages. In none of the cases was a recurrence of the fluid collections seen during the follow-up. CONCLUSION: These results suggest that in infants with symptomatic chronic subdural fluid collections who fail to respond to repeated tapping, the early placement of an unilateral subdural-peritoneal shunt with a low pressure valve represents a safe, benign, and effective treatment option.
Cerebrospinal Fluid Shunts↗
Coil embolization of an incidental posterior cerebral artery aneurysm after initial OA-PCA bypass surgery.
Aneurysms of the posterior cerebral artery (PCA) are rare and imply a variety of treatment modalities. We present a case of an incidental, nonruptured posterior cerebral artery aneurysm, which was successfully occluded by coil embolization after a bypass between the occipital artery and the distal posterior cerebral artery was created. MR imaging in a neurologically normal 26-year-old man, performed in the course of a work-up for nonrelated symptoms, incidentally revealed a partially thrombosed and calcified aneurysm of the left posterior cerebral artery (P2 segment). This was confirmed by angiography. Due to aneurysm configuration and localization in the asymptomatic patient, primary clipping or endovascular occlusion was considered to be too hazardous. Four weeks after successful microvascular connection of the left occipital artery to the distal posterior cerebral artery, the PCA was occluded at the level of the aneurysm with a detachable coil. The patient remained asymptomatic, without visual field defects. The above presented combined microvascular (bypass) and endovascular (coil embolization) treatment with excellent result should be considered as alternative in patients with nonruptured, asymptomatic P2 aneurysms, which are high risk for primary clipping or endovascular occlusion.
Adult↗
Anomalies and variants of the endoscopic anatomy for third ventriculostomy.
OBJECTIVE: Endoscopic third ventriculostomy (ETV) is an alternative to shunt placement in occlusive hydrocephalus. The negative impact of anatomic anomalies and variants on ETV have been sporadically reported but not yet investigated systematically. Therefore, the objectives of the present study are 1) to evaluate the frequency of endoscopic anatomic anomalies of the ventricular system, 2) to define their potential to complicate the procedure and to compromise the surgical results, and 3) to investigate the value of preoperative magnetic resonance (MR) imaging for their detection. METHOD: The video recordings, the operative reports, and the preoperative MR images of 25 hydrocephalic patients who underwent ETV were reviewed. The surgical results were classified into completed and successful, completed, but failed, and unsuccessfully attempted ETV and were correlated with the absence or presence of anatomic variants. RESULTS: In 9 of the 25 patients, 10 anatomic anomalies or variants, respectively, were identified, accounting for an incidence rate of 36%. The single most common anatomic anomaly was a thickened third ventricular floor in 4 patients. Anatomic variants extended the operation time (n = 6), increased the stretching of floor and walls of the third ventricle during perforation (n = 4), were related to minor arterial bleeding (n = 3), and obscured the visual control of the basilar artery (n = 2). In 5 of the 9 patients, ETV was completed and successful, but in 2 patients, ETV was finally abandoned, and in an additional 2 patients, ETV was completed, but failed to cure the symptoms of hydrocephalus. In contrast, ETV was completed and successful in all 16 patients with normal anatomy. All anatomic anomalies had been detectable on preoperative MR imaging, with the exception of the thickened floor of the third ventricle. CONCLUSION: Anatomic anomalies are a frequent finding during ETV. Successful perforation and control of the hydrocephalus correlates with the absence of anatomic anomalies. Most anatomic variants have the potential to increase the operative risk. With the exception of the thickened third ventricular floor, MR imaging allows us to identify all anatomic anomalies preoperatively, and enables the neurosurgeon to weigh the operative risk in a patient with an anatomic anomaly against the chance to perform ETV successfully.
Adolescent↗
Frameless stereotactically guided catheter placement and fibrinolytic therapy for spontaneous intracerebral hematomas: technical aspects and initial clinical results.
OBJECTIVE: Frame-based stereotactic puncture and catheter placement followed by fibrinolytic therapy and drainage is one treatment option in the management of spontaneous intracerebral hemorrhage (sICH). This minimally invasive procedure could even be simplified by frameless stereotaxy. The authors present their experiences with frameless stereotactic image-guided catheter placement for lysis and drainage of sICH, with emphasis on technical aspects. METHOD: In 27 patients with sICH, an infrared-based frameless stereotactic device was used for selecting trajectory and target point of hematoma drainage. A trajectory along the main axis of the hematoma was considered to be optimal for fibrinolytic therapy. An articulated arm served to maintain the predetermined trajectory during surgery and to guide catheter advancement. Clot lysis with recombinant tissue plasminogen activator (rt-PA) was initiated after radiological confirmation of correct catheter positioning. RESULTS: In all cases, selection of the optimal trajectory was not restricted by the frameless stereotactic device. In 25 of the 27 patients, the catheter was placed accurately along the predetermined trajectory into the target point. In two patients, the catheter was positioned at the lateral margin of the hematoma, excluding fibrinolytic therapy in one case. In 24 of 27 patients, the mean hematoma volume could be reduced from initially 52 ml to 17 ml in an average of two days. Hematoma enlargement following rt-PA injection was observed in two patients. Further complications were culture negative pleocytosis of cerebrospinal fluid in two and meningitis in one patient. CONCLUSION: Hematoma puncture and catheter placement for fibrinolytic therapy could be achieved with high accuracy and safety using frameless stereotaxy. This method allows unrestricted trajectory selection with catheter positioning along the main hematoma axis. Further studies are required to investigate if frameless stereotactic puncture and clot lysis could contribute to improve the outcome of patients with sICH.
Adult↗
Prospective analysis of bedside percutaneous subdural tapping for the treatment of chronic subdural haematoma in adults.
OBJECTIVES: Although there is general agreement that surgery is the best treatment for chronic subdural haematoma (CSDH), the extent of the surgical intervention is not well defined. METHODS: The less invasive surgical technique of bedside percutaneous subdural tapping and spontaneous haematoma efflux after twist drill craniostomy under local anaesthesia was prospectively analysed in 118 adult patients, 99 with unilateral and 19 with bilateral CSDH. RESULTS: The mean number of subdural tappings was 3.2. Ninety two of the patients with unilateral CSDH were successfully treated by up to five subdural tappings, 95% of the patients with bilateral CSDH were successfully treated by up to 10 subdural tappings. The mean duration of inpatient treatment was 12 days. In 11 patients (9%) the treatment protocol had to be abandoned because of two acute subdural bleedings, two subdural empyemas, and seven cases of insufficient haematoma efflux and no neurological improvement. The only significant predictor for failure of the described treatment protocol was septation visible on preoperative CT. CONCLUSIONS: The described therapy protocol is-apart from a purely conservative treatment-the least invasive presently available surgical technique for treating chronic subdural haematoma. Its results are comparable with other modern treatment protocols. Thus, it can be recommended in all patients as a first and minimally invasive therapy, especially in patients in a poor general condition. Patients with septation visible on preoperative CT should be excluded from this form of treatment.
Adult↗
Functional outcome after aneurysmal subarachnoid hemorrhage.
The introduction of the operating microscope, the principle of early surgery, specialized intensive care units, the calcium antagonist nimodipine, the sophisticated pre- and postoperative management and an aggressive antiischemic pharmacological management have substantially reduced morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). In spite of this progress, many patients after rupture and surgical repair of an intracranial aneurysm exhibit substantial cognitive deficits and emotional problems although their neurological outcome was rated as good according to the Glasgow Outcome Scale (GOS = I). Therefore, a comprehensive neuropsychological examination is called for in order to evaluate the factual functional outcome after SAH. Neither focal brain damage associated with aneurysm location nor surgery but the hemorrhage itself and related events can be regarded as the most important causal factors for the late result after SAH. In contrast to the mild permanent effects of aneurysm surgery, the initial bleeding itself seems to have substantial lasting adverse neurobehavioral effects after. In concordance with other authors our own data stress the strong predictive power of the bleeding pattern such as the presence of intraventricular and/or intracerebral blood on the functional outcome after aneurysmal SAH.
Aneurysm, Ruptured↗
Modification of a mechanical twist drill trephine for craniostomy in trauma patients.
A commercially available mechanical twist drill system was modified and evaluated in 35 craniotomies for frontal ventriculostomy in 31 trauma patients. The modified mechanical twist drill enabled faster and seemingly easier and safer craniotomy. It can be used as a safer alternative to common mechanical twist drill trephines, and is particularly recommended in difficult emergency conditions.
Adult↗
Foreign body granuloma mimicking a benign intraspinal tumour.
We describe the case of an intraspinal foreign body granuloma that became symptomatic 23 years after a lumbar discectomy. Preoperatively, the foreign body granuloma was misdiagnosed as spinal neurinoma.
Diagnosis, Differential↗